Postoperative Care of Living Donor for Liver Transplant

Chapter

Keywords

Donor risk Left-lobe graft Liver transplantation Living donor Mortality Perioperative care Epidemiology Ethics Bile leak Pulmonary embolism Liver failure 

Notes

Acknowledgments

We would like to thank Dr. Patrick M. Mcquillan M.D. for helping review the manuscript.

References

  1. 1.
  2. 2.
    Trotter JF, Adam R, Lo CM, Kenison J. Documented deaths of hepatic lobe donors for living donor liver transplantation. Liver Transpl. 2006;12(10):1485–8.CrossRefPubMedGoogle Scholar
  3. 3.
    Iida T, Ogura Y, Oike F, Hatano E, Kaido T, Egawa H, et al. Surgery-related morbidity in living donors for liver transplantation. Transplantation. 2010;89(10):1276–82.CrossRefPubMedGoogle Scholar
  4. 4.
    Hwang S, Lee SG, Lee YJ, Sung KB, Park KM, Kim KH, et al. Lessons learned from 1,000 living donor liver transplantations in a single center: how to make living donations safe. Liver Transpl. 2006;12(6):920–7.CrossRefPubMedGoogle Scholar
  5. 5.
    Levy GA, Selzner N, Grant DR. Fostering liver living donor liver transplantation. Curr Opin Organ Transplant. 2016;21(2):224–30.CrossRefPubMedGoogle Scholar
  6. 6.
    Ghobrial RM, Freise CE, Trotter JF, Tong L, Ojo AO, Fair JH, et al. Donor morbidity after living donation for liver transplantation. Gastroenterology. 2008;135(2):468–76.CrossRefPubMedPubMedCentralGoogle Scholar
  7. 7.
    Broering DC, Wilms C, Bok P, Fischer L, Mueller L, Hillert C, et al. Evolution of donor morbidity in living related liver transplantation: a single-center analysis of 165 cases. Ann Surg. 2004;240(6):1013–24. discussions 24–6CrossRefPubMedPubMedCentralGoogle Scholar
  8. 8.
    Miller CM, Durand F, Heimbach JK, Kim-Schluger L, Lee SG, Lerut J, et al. The International Liver Transplant Society Guideline on living liver donation. Transplantation. 2016;100(6):1238–43.CrossRefPubMedGoogle Scholar
  9. 9.
    Yonemura Y, Taketomi A, Soejima Y, Yoshizumi T, Uchiyama H, Gion T, et al. Validity of preoperative volumetric analysis of congestion volume in living donor liver transplantation using three-dimensional computed tomography. Liver Transpl. 2005;11(12):1556–62.CrossRefPubMedGoogle Scholar
  10. 10.
    Marsh JW, Gray E, Ness R, Starzl TE. Complications of right lobe living donor liver transplantation. J Hepatol. 2009;51(4):715–24.CrossRefPubMedPubMedCentralGoogle Scholar
  11. 11.
    Yi NJ, Suh KS, Cho JY, Lee HW, Cho EH, Yang SH, et al. Three-quarters of right liver donors experienced postoperative complications. Liver Transpl. 2007;13(6):797–806.CrossRefPubMedGoogle Scholar
  12. 12.
    Braun HJ, Dodge JL, Roll GR, Freise CE, Ascher NL, Roberts JP. Impact of graft selection on donor and recipient outcomes after living donor liver transplantation. Transplantation. 2016;100(6):1244–50.CrossRefPubMedPubMedCentralGoogle Scholar
  13. 13.
    Park JI, Kim KH, Lee SG. Laparoscopic living donor hepatectomy: a review of current status. J Hepatobiliary Pancreat Sci. 2015;22(11):779–88.CrossRefPubMedGoogle Scholar
  14. 14.
    Wakabayashi G, Cherqui D, Geller DA, Buell JF, Kaneko H, Han HS, et al. Recommendations for laparoscopic liver resection: a report from the second international consensus conference held in Morioka. Ann Surg. 2015;261(4):619–29.PubMedGoogle Scholar
  15. 15.
    Brown RS Jr. Live donors in liver transplantation. Gastroenterology. 2008;134(6):1802–13.CrossRefPubMedPubMedCentralGoogle Scholar
  16. 16.
    Shiffman ML, Brown RS Jr, Olthoff KM, Everson G, Miller C, Siegler M, et al. Living donor liver transplantation: summary of a conference at the National Institutes of Health. Liver Transpl. 2002;8(2):174–88.CrossRefPubMedGoogle Scholar
  17. 17.
  18. 18.
    Brown RS Jr, Higgins R, Pruett TL. The evolution and direction of OPTN oversight of live organ donation and transplantation in the United States. Am J Transplant. 2009;9(1):31–4.CrossRefPubMedGoogle Scholar
  19. 19.
    Manas D, Burnapp L, Andrews PA. Summary of the British Transplantation Society UK Guidelines for living donor liver transplantation. Transplantation. 2016;100(6):1184–90.CrossRefPubMedGoogle Scholar
  20. 20.
    Olthoff KM. Hepatic regeneration in living donor liver transplantation. Liver Transpl. 2003;9(10 Suppl 2):S35–41.CrossRefPubMedGoogle Scholar
  21. 21.
    Candido HL, da Fonseca EA, Feier FH, Pugliese R, Benavides MA, Silva ED, et al. Risk factors associated with increased morbidity in living liver donation. J Transp Secur. 2015;2015:949674.Google Scholar
  22. 22.
    Gruttadauria S, Marsh JW, Vizzini GB, di Francesco F, Luca A, Volpes R, et al. Analysis of surgical and perioperative complications in seventy-five right hepatectomies for living donor liver transplantation. World J Gastroenterol. 2008;14(20):3159–64.CrossRefPubMedPubMedCentralGoogle Scholar
  23. 23.
    Risk of and prophylaxis for venous thromboembolism in hospital patients. Thromboembolic Risk Factors (THRIFT) Consensus Group. BMJ. 1992;305(6853):567–74.Google Scholar
  24. 24.
    Tripodi A, Salerno F, Chantarangkul V, Clerici M, Cazzaniga M, Primignani M, et al. Evidence of normal thrombin generation in cirrhosis despite abnormal conventional coagulation tests. Hepatology. 2005;41(3):553–8.CrossRefGoogle Scholar
  25. 25.
    Mohammed M, Fayed N, Hassanen A, Ahmed F, Mourad W, El Sheikh M, et al. Rotational thromboelastometry and standard coagulation tests for live liver donors. Clin Transpl. 2013;27(2):E101–8.CrossRefGoogle Scholar
  26. 26.
    Cerutti E, Stratta C, Romagnoli R, Schellino MM, Skurzak S, Rizzetto M, et al. Thromboelastogram monitoring in the perioperative period of hepatectomy for adult living liver donation. Liver Transpl. 2004;10(2):289–94.CrossRefPubMedGoogle Scholar
  27. 27.
    Gouvea G, Diaz R, Auler L, Toledo R, Soluri A, Haack AG, et al. Perioperative coagulation profile in living liver donors as assessed by rotational thromboelastometry. Liver Transpl. 2010;16(3):387–92.PubMedGoogle Scholar
  28. 28.
    Mismetti P, Laporte S, Darmon JY, Buchmuller A, Decousus H. Meta-analysis of low molecular weight heparin in the prevention of venous thromboembolism in general surgery. Br J Surg. 2001;88(7):913–30.CrossRefPubMedGoogle Scholar
  29. 29.
    Itamoto T, Emoto K, Mitsuta H, Fukuda S, Ohdan H, Tashiro H, et al. Safety of donor right hepatectomy for adult-to-adult living donor liver transplantation. Transpl Int. 2006;19(3):177–83.CrossRefPubMedGoogle Scholar
  30. 30.
    Fan ST, Lo CM, Liu CL, Yong BH, Chan JK, Ng IO. Safety of donors in live donor liver transplantation using right lobe grafts. Arch Surg. 2000;135(3):336–40.CrossRefPubMedGoogle Scholar
  31. 31.
    Borromeo CJ, Stix MS, Lally A, Pomfret EA. Epidural catheter and increased prothrombin time after right lobe hepatectomy for living donor transplantation. Anesth Analg. 2000;91(5):1139–41.PubMedGoogle Scholar
  32. 32.
    Marcos A, Fisher RA, Ham JM, Shiffman ML, Sanyal AJ, Luketic VA, et al. Liver regeneration and function in donor and recipient after right lobe adult to adult living donor liver transplantation. Transplantation. 2000;69(7):1375–9.CrossRefGoogle Scholar
  33. 33.
    Khan J, Katz J, Montbriand J, Ladak S, McCluskey S, Srinivas C, et al. Surgically placed abdominal wall catheters on postoperative analgesia and outcomes after living liver donation. Liver Transpl. 2015;21(4):478–86.CrossRefPubMedPubMedCentralGoogle Scholar
  34. 34.
    Ntinas A, Kardassis D, Konstantinopoulos I, Kottos P, Manias A, Kyritsi M, et al. Duration of the thoracic epidural catheter in a fast-track recovery protocol may decrease the length of stay after a major hepatectomy: a case control study. Int J Surg. 2013;11(9):882–5.CrossRefGoogle Scholar
  35. 35.
    Revie EJ, McKeown DW, Wilson JA, Garden OJ, Wigmore SJ. Randomized clinical trial of local infiltration plus patient-controlled opiate analgesia vs. epidural analgesia following liver resection surgery. HPB (Oxford). 2012;14(9):611–8.CrossRefGoogle Scholar
  36. 36.
    Savikko J, Ilmakunnas M, Makisalo H, Nordin A, Isoniemi H. Enhanced recovery protocol after liver resection. Br J Surg. 2015;102(12):1526–32.CrossRefGoogle Scholar
  37. 37.
    Amini N, Kim Y, Hyder O, Spolverato G, Wu CL, Page AJ, et al. A nationwide analysis of the use and outcomes of perioperative epidural analgesia in patients undergoing hepatic and pancreatic surgery. Am J Surg. 2015;210(3):483–91.CrossRefPubMedPubMedCentralGoogle Scholar
  38. 38.
    Aydogan MS, Bicakcioglu M, Sayan H, Durmus M, Yilmaz S. Effects of two different techniques of postoperative analgesia management in liver transplant donors: a prospective, randomized, double-blind study. Transplant Proc. 2015;47(4):1204–6.CrossRefGoogle Scholar
  39. 39.
    De Pietri L, Siniscalchi A, Reggiani A, Masetti M, Begliomini B, Gazzi M, et al. The use of intrathecal morphine for postoperative pain relief after liver resection: a comparison with epidural analgesia. Anesth Analg. 2006;102(4):1157–63.CrossRefGoogle Scholar
  40. 40.
    Niraj G, Kelkar A, Jeyapalan I, Graff-Baker P, Williams O, Darbar A, et al. Comparison of analgesic efficacy of subcostal transversus abdominis plane blocks with epidural analgesia following upper abdominal surgery. Anaesthesia. 2011;66(6):465–71.CrossRefGoogle Scholar
  41. 41.
    Serag Eldin M, Mahmoud F, El Hassan R, Abdel Raouf M, Afifi MH, Yassen K, et al. Intravenous patient-controlled fentanyl with and without transversus abdominis plane block in cirrhotic patients post liver resection. Local Reg Anesth. 2014;7:27–37.PubMedPubMedCentralGoogle Scholar
  42. 42.
    Abdelsalam K, Mohamdin OW. Ultrasound-guided rectus sheath and transversus abdominis plane blocks for perioperative analgesia in upper abdominal surgery: a randomized controlled study. Saudi J Anaesth. 2016;10(1):25–8.CrossRefPubMedPubMedCentralGoogle Scholar
  43. 43.
    Trotter JF, Talamantes M, McClure M, Wachs M, Bak T, Trouillot T, et al. Right hepatic lobe donation for living donor liver transplantation: impact on donor quality of life. Liver Transpl. 2001;7(6):485–93.CrossRefPubMedGoogle Scholar
  44. 44.
    Renz JF, Busuttil RW. Adult-to-adult living-donor liver transplantation: a critical analysis. Semin Liver Dis. 2000;20(4):411–24.CrossRefPubMedGoogle Scholar
  45. 45.
    Pomfret EA, Pomposelli JJ, Lewis WD, Gordon FD, Burns DL, Lally A, et al. Live donor adult liver transplantation using right lobe grafts: donor evaluation and surgical outcome. Arch Surg. 2001;136(4):425–33.CrossRefPubMedGoogle Scholar
  46. 46.
    Miller CM, Gondolesi GE, Florman S, Matsumoto C, Munoz L, Yoshizumi T, et al. One hundred nine living donor liver transplants in adults and children: a single-center experience. Ann Surg. 2001;234(3):301–11. discussion 11–2CrossRefPubMedPubMedCentralGoogle Scholar
  47. 47.
    Ibrahim S, Chen CL, Lin CC, Yang CH, Wang CC, Wang SH, et al. Intraoperative blood loss is a risk factor for complications in donors after living donor hepatectomy. Liver Transpl. 2006;12(6):950–7.CrossRefPubMedGoogle Scholar
  48. 48.
    Grewal HP, Shokouh-Amiri MH, Vera S, Stratta R, Bagous W, Gaber AO. Surgical technique for right lobe adult living donor liver transplantation without venovenous bypass or portocaval shunting and with duct-to-duct biliary reconstruction. Ann Surg. 2001;233(4):502–8.CrossRefPubMedPubMedCentralGoogle Scholar
  49. 49.
    Ghobrial RM, Saab S, Lassman C, Lu DS, Raman S, Limanond P, et al. Donor and recipient outcomes in right lobe adult living donor liver transplantation. Liver Transpl. 2002;8(10):901–9.CrossRefPubMedGoogle Scholar
  50. 50.
    Marcos A, Fisher RA, Ham JM, Shiffman ML, Sanyal AJ, Luketic VA, et al. Right lobe living donor liver transplantation. Transplantation. 1999;68(6):798–803.CrossRefPubMedGoogle Scholar
  51. 51.
    Beavers KL, Sandler RS, Fair JH, Johnson MW, Shrestha R. The living donor experience: donor health assessment and outcomes after living donor liver transplantation. Liver Transpl. 2001;7(11):943–7.CrossRefPubMedGoogle Scholar
  52. 52.
    Beavers KL, Sandler RS, Shrestha R. Donor morbidity associated with right lobectomy for living donor liver transplantation to adult recipients: a systematic review. Liver Transpl. 2002;8(2):110–7.CrossRefPubMedGoogle Scholar
  53. 53.
    Adam R, McMaster P, O’Grady JG, Castaing D, Klempnauer JL, Jamieson N, et al. Evolution of liver transplantation in Europe: report of the European liver transplant registry. Liver Transpl. 2003;9(12):1231–43.CrossRefPubMedGoogle Scholar
  54. 54.
    Umeshita K, Fujiwara K, Kiyosawa K, Makuuchi M, Satomi S, Sugimachi K, et al. Operative morbidity of living liver donors in Japan. Lancet. 2003;362(9385):687–90.CrossRefPubMedGoogle Scholar
  55. 55.
    Clavien PA, Camargo CA Jr, Croxford R, Langer B, Levy GA, Greig PD. Definition and classification of negative outcomes in solid organ transplantation. Application in liver transplantation. Ann Surg. 1994;220(2):109–20.CrossRefPubMedPubMedCentralGoogle Scholar
  56. 56.
    Clavien PA, Sanabria JR, Strasberg SM. Proposed classification of complications of surgery with examples of utility in cholecystectomy. Surgery. 1992;111(5):518–26.PubMedGoogle Scholar
  57. 57.
    Patel S, Orloff M, Tsoulfas G, Kashyap R, Jain A, Bozorgzadeh A, et al. Living-donor liver transplantation in the United States: identifying donors at risk for perioperative complications. Am J Transplant. 2007;7(10):2344–9.CrossRefPubMedGoogle Scholar
  58. 58.
    Taketomi A, Kayashima H, Soejima Y, Yoshizumi T, Uchiyama H, Ikegami T, et al. Donor risk in adult-to-adult living donor liver transplantation: impact of left lobe graft. Transplantation. 2009;87(3):445–50.CrossRefPubMedGoogle Scholar
  59. 59.
    Durand F, Ettorre GM, Douard R, Denninger MH, Kianmanesh A, Sommacale D, et al. Donor safety in living related liver transplantation: underestimation of the risks for deep vein thrombosis and pulmonary embolism. Liver Transpl. 2002;8(2):118–20.CrossRefPubMedGoogle Scholar
  60. 60.
    Wakeno-Takahashi M, Nakao S, Ikeda S, Kaibori M, Yamamoto H, Yanagida H, et al. A case of suspected severe pulmonary embolism in a living-related liver transplantation donor. J Clin Anesth. 2005;17(3):218–20.CrossRefGoogle Scholar
  61. 61.
    Bezeaud A, Denninger MH, Dondero F, Saada V, Venisse L, Huisse MG, et al. Hypercoagulability after partial liver resection. Thromb Haemost. 2007;98(6):1252–6.PubMedGoogle Scholar
  62. 62.
    Bustelos R, Ayala R, Martinez J, Martin MA, Toledo T, Grande S, et al. Living donor liver transplantation: usefulness of hemostatic and prothrombotic screening in potential donors. Transplant Proc. 2009;41(9):3791–5.CrossRefGoogle Scholar
  63. 63.
    Akabayashi A, Slingsby BT, Fujita M. The first donor death after living-related liver transplantation in Japan. Transplantation. 2004;77(4):634.CrossRefPubMedGoogle Scholar
  64. 64.
    Malago M, Testa G, Frilling A, Nadalin S, Valentin-Gamazo C, Paul A, et al. Right living donor liver transplantation: an option for adult patients: single institution experience with 74 patients. Ann Surg. 2003;238(6):853–62. discussion 62–3CrossRefPubMedPubMedCentralGoogle Scholar
  65. 65.
    Margonis GA, Amini N, Buettner S, Besharati S, Kim Y, Sobhani F, et al. Impact of early postoperative platelet count on volumetric liver gain and perioperative outcomes after major liver resection. Br J Surg. 2016;103(7):899–907.CrossRefPubMedGoogle Scholar
  66. 66.
    Han S, Park HW, Song JH, Gwak MS, Lee WJ, Kim G, et al. Association between intraoperative platelet transfusion and early graft regeneration in living donor liver transplantation. Ann Surg. 2016;264(6):1065–72.CrossRefPubMedGoogle Scholar
  67. 67.
    Tanemura A, Mizuno S, Wada H, Yamada T, Nobori T, Isaji S. Donor age affects liver regeneration during early period in the graft liver and late period in the remnant liver after living donor liver transplantation. World J Surg. 2012;36(5):1102–11.CrossRefPubMedGoogle Scholar
  68. 68.
    Polson J, Lee WM, American Association for the Study of Liver Disease. AASLD position paper: the management of acute liver failure. Hepatology. 2005;41(5):1179–97.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of AnesthesiologyUniversity of Michigan Health SystemAnn ArborUSA
  2. 2.Abdominal Transplantation and Hepatobiliary SurgeryAllegheny General HospitalPittsburghUSA
  3. 3.Department of AnesthesiologyUniversity of MichiganAnn ArborUSA

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