Abstract
Oxygen is a structural and functional compound essential to life. Evoking the toxicity of this molecule could seem inappropriate or even provocative. After its discovery by Priestley in 1774, Lavoisier named it “oxygen” from the Greek words oxys and gennan meaning “generating acid”. At the same time, he demonstrated its essential role in respiration. This emphasized immediately the duality of this molecule to which the vast majority of living organisms have had to adapt, especially as, in particular circumstances, oxygen can be harmful because of its oxidative characteristics.
References
Favier A (2006) Stress oxydant et pathologie humaine. Ann Pharm Fr 64:390–396
Kohen R, Nyska A (2002) Oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification. Toxicol Pathol 30:620–650
Droge W (2002) Free radicals in the physiological control of cell function. Physiol Rev 82:47–95
Levraut J, Iwase H, Shao ZH, Vanden Hoek TL, Schumacker PT (2003) Cell death during ischemia: relationship to mitochondrial depolarization and ROS generation. Am J Physiol Heart Circ Physiol 284:549–558
Piper HM, Garcia-Dorado D, Ovize M (1998) A fresh look at reperfusion injury. Cardiovasc Res 38:291–300
Vanden Hoek TL (2002) Preconditioning and postresuscitation injury. Crit Care Med 30:S172–S175
Dahlgren C, Karlsson A (1999) Respiratory burst in human neutrophils. J Immunol Methods 232:3–14
Lebuffe G, Schumacker PT, Shao ZH, Anderson T, Iwase H, Vanden Hoek TL (2003) ROS and NO trigger early preconditioning: relationship to mitochondrial KATP channel. Am J Physiol Heart Circ Physiol 284:H299–H308
Halliwell B, Gutteridge JM (1988) Free radicals and antioxidants protection: mechanisms and significance in toxicology and disease. Hum Toxicol 7:7–13
Fridovich I (1995) Superoxide radical and superoxide dismutases. Annu Rev Biochem 64:97–112
Richier S, Merle PL, Furla P, Pigozzi D, Sola F, Allemand D (2003) Characterization of superoxide dismutases in anoxia- and hyperoxia-tolerant symbiotic cnidarians. Biochim Biophys Acta 1621:84–91
Schnackenberg CG, Welch WJ, Wilcox CS (1998) Normalization of blood pressure and renal vascular resistance in SHR with a membrane-permeable superoxide dismutase mimetic: role of nitric oxide. Hypertension 32:59–64
Kirkman HN, Rolfo M, Ferraris AM, Gaetani GF (1999) Mechanisms of protection of catalase by NADPH. Kinetics and stoichiometry J Biol Chem 274:13908–13914
Giacco F, Brownlee M (2010) Oxidative stress and diabetic complications. Circ Res 107:1058–1070
Briones AM, Touyz RM (2010) Oxidative stress and hypertension: current concepts. Curr Hypertens Rep 12:135–142
Khaper N, Bryan S, Dhingra S, Singal R, Bajaj A, Pathak CM, Singal PK (2010) Targeting the vicious inflammation-oxidative stress cycle for the management of heart failure. Antioxid Redox Signal 13:1033–1049
Romano AD, Serviddio G, de Matthaeis A, Bellanti F, Vendemiale G (2010) Oxidative stress and aging. J Nephrol 23:S29–S36
Laplace C, Huet O, Vicaut E, Ract C, Martin L, Benhamou D, Duranteau J (2005) Endothelial oxidative stress induced by serum from patients with severe trauma hemorrhage. Intensive Care Med 31:1174–1180
Huet O, Obata R, Aubron C, Spraul-Davit A, Charpentier J, Laplace C, Nguyen-Khoa T, Conti M, Vicaut E, Mira JP, Duranteau J (2007) Plasma-induced endothelial oxidative stress is related to the severity of septic shock. Crit Care Med 35:821–826
Fläring UB, Rooyackers OE, Hebert C, Bratel T, Hammarqvist F, Wernerman J (2005) Temporal changes in whole-blood and plasma glutathione in ICU patients with multiple organ failure. Intensive Care Med 31:1072–1078
Motoyama T, Okamoto K, Kukita I, Hamaguchi M, Kinoshita Y, Ogawa H (2003) Possible role of increased oxidant stress in multiple organ failure after systemic inflammatory response syndrome. Crit Care Med 31:1048–1052
Carpenter CT, Price PV, Christman BW (1998) Exhaled breath condensate isoprostanes are elevated in patients with acute lung injury or ARDS. Chest 114:1653–1659
Quinlan GJ, Lamb NJ, Evans TW, Gutteridge JM (1996) Plasma fatty acid changes and increased lipid peroxidation in patients with adult respiratory distress syndrome. Crit Care Med 24:241–246
Lamb NJ, Quinlan GJ, Westerman ST, Gutteridge JM, Evans TW (1999) Nitration of proteins in bronchoalveolar lavage fluid from patients with acute respiratory distress syndrome receiving inhaled nitric oxide. Am J Respir Crit Care Med 160:1031–1034
Quinlan GJ, Mumby S, Martin GS, Bernard GR, Gutteridge JM, Evans TW (2004) Albumin influences total plasma antioxidant capacity favorably in patients with acute lung injury. Crit Care Med 32:755–759
Asano T (1999) Oxyhemoglobin as the principal cause of cerebral vasospasm: a holistic view of its actions. Crit Rev Neurosurg 9:303–318
Polidori MC, Mecocci P, Frei B (2001) Plasma vitamin C levels are decreased and correlated with brain damage in patients with intracranial hemorrhage or head trauma. Stroke 32:898–902
Gaetani P, Pasqualin A, Rodriguez y Baena R, Borasio E, Marzatico F (1998) Oxidative stress in the human brain after subarachnoid hemorrhage. J Neurosurg 89:748–754
Déroche D, Orban JC, Garrel C, Ferrari P, Levraut J, Ichai C (2009) Evaluation du stress oxydant après cardiaque extra-hospitalier traité par hypothermie. Ann Fr Anesth Réanim 28:S170
Kilgannon JH, Jones AE, Shapiro NI, Angelos MG, Milcarek B, Hunter K, Parrillo JE, Trzeciak S, Emergency Medicine Shock Research Network (EMShockNet) Investigators (2010) Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality. JAMA 303:2165–2171
Mathru M, Dries DJ, Barnes L, Tonino P, Sukhani R, Rooney MW (1996) Tourniquet-induced exsanguination in patients requiring lower limb surgery. An ischemia-reperfusion model of oxidant and antioxidant metabolism. Anesthesiology 84:14–22
Kretzschmar M, Klein U, Palutke M, Schirrmeister W (1996) Reduction of ischemia-reperfusion syndrome after abdominal aortic aneurysmectomy by N-acetylcysteine but not mannitol. Acta Anaesthesiol Scand 40:657–664
Basu S, Meisert I, Eggensperger E, Krieger E, Krenn CG (2007) Time course and attenuation of ischaemia-reperfusion induced oxidative injury by propofol in human renal transplantation. Redox Rep 12:195–202
Biernacki M, Bigda J, Jankowski K, Wozniak M, Sledziński Z (2002) Increased serum levels of markers of oxidative stress during kidney transplantation. Transplant Proc 34:544–545
Hassan L, Bueno P, Ferrón-Celma I, Ramia JM, Garrote D, Muffak K, García-Navarro A, Mansilla A, Villar JM, Ferrón JA (2005) Time course of antioxidant enzyme activities in liver transplant recipients. Transplant Proc 37:3932–3935
Emet S, Memis D, Pamukçu Z (2004) The influence of N-acetyl-L-cysteine infusion on cytokine levels and gastric intramucosal pH during severe sepsis. Crit Care 8:172–179
Spapen H, Zhang H, Demanet C, Vleminckx W, Vincent JL, Huyghens L (1998) Does N-acetyl-L-cysteine influence cytokine response during early human septic shock? Chest 113:1616–1624
Ortolani O, Conti A, De Gaudio AR, Moraldi E, Cantini Q, Novelli G (2000) The effect of glutathione and N-acetylcysteine on lipoperoxidative damage in patients with early septic shock. Am J Respir Crit Care Med 161:1907–1911
Ho KM, Morgan DJ (2009) Meta-analysis of N-acetylcysteine to prevent acute renal failure after major surgery. Am J Kidney Dis 53:33–40
Crimi E, Liguori A, Condorelli M, Cioffi M, Astuto M, Bontempo P, Pignalosa O, Vietri MT, Molinari AM, Sica V, Della Corte F, Napoli C (2004) The beneficial effects of antioxidant supplementation in enteral feeding in critically ill patients: a prospective, randomized, double-blind, placebo-controlled trial. Anesth Analg 99:857–863
Heyland D, Muscedere J, Wischmeyer PE, Cook D, Jones G, Albert M, et al. A randomized trial of glutamine and antioxidants in critically ill patients. N Engl J Med. 2013;368:1489–97
Nathens AB, Neff MJ, Jurkovich GJ, Klotz P, Farver K, Ruzinski JT, Radella F, Garcia I, Maier RV (2002) Randomized, prospective trial of antioxidant supplementation in critically ill surgical patients. Ann Surg 236:814–822
Collier BR, Giladi A, Dossett LA, Dyer L, Fleming SB, Cotton BA (2008) Impact of high-dose antioxidants on outcomes in acutely injured patients. JPEN J Parenter Enteral Nutr 3:384–388
Cheng YJ, Wang YP, Chien CT, Chen CF (2002) Small-dose propofol sedation attenuates the formation of reactive oxygen species in tourniquet-induced ischemia-reperfusion injury under spinal anesthesia. Anesth Analg 94:1617–1620
Vanden Hoek T, Becker LB, Shao ZH, Li CQ, Schumacker PT (2000) Preconditioning in cardiomyocytes protects by attenuating oxidant stress at reperfusion. Circ Res 86:541–548
Murry CE, Jennings RB, Reimer KA (1986) Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 74:1124–1136
Wu ZK, Tarkka MR, Pehkonen E, Kaukinen L, Honkonen EL, Kaukinen S (2000) Ischaemic preconditioning has a beneficial effect on left ventricular haemodynamic function after a coronary artery biopass grafting operation. Scand Cardiovasc J 34:247–253
Wu ZK, Iivainen T, Pehkonen E, Laurikka J, Tarkka MR (2002) Ischemic preconditioning suppresses ventricular tachyarrhythmias after myocardial revascularization. Circulation 106:3091–3096
Hausenloy DJ, Mwamure PK, Venugopal V, Harris J, Barnard M, Grundy E, Ashley E, Vichare S, Di Salvo C, Kolvekar S, Hayward M, Keogh B, MacAllister RJ, Yellon DM (2007) Effect of remote ischaemic preconditioning on myocardial injury in patients undergoing coronary artery bypass graft surgery: a randomised controlled trial. Lancet 370:575–579
Zaugg M, Lucchinetti E, Spahn DR, Pasch T, Schaub MC (2002) Volatile anesthetics mimic cardiac preconditioning by priming the activation of mitochondrial K(ATP) channels via multiple signaling pathways. Anesthesiology 97:4–14
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Orban, JC., Singer, M. (2018). Oxygen and Oxidative Stress. In: Ichai, C., Quintard, H., Orban, JC. (eds) Metabolic Disorders and Critically Ill Patients. Springer, Cham. https://doi.org/10.1007/978-3-319-64010-5_20
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DOI: https://doi.org/10.1007/978-3-319-64010-5_20
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