Abstract
The prevalence of cholelithiasis or gallstones is highly variable throughout the world with a much higher prevalence well published in several ethnicities. Gallstones are common in the adult population affecting over 10–15% of the Caucasian adult population in developed countries [1–3]. However in certain ethnicities, such as North American Indians including Pima Indians, Chippewa Indians, Canadian Micmac Indians and other American Indian tribes in Arizona/Oklahoma/Dakotas, prevalence can be as high as 60–70% of the population [4, 5]. See Fig. 3.1.
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References
Marshall HU, Einarsson C. Gallstone disease. J Intern Med. 2007;261:529–42.
Shaffer EA. Gallstone disease: epidemiology of gallbladder stone disease. BestPract Res Clin Gastroenterol. 2006;20(6):981–96.
Friedman GD. Natural history of asymptomatic and symptomatic gallstones. Am J Surg. 1993;165:399–404.
Shaffer EA. Epidemiology of gallbladder stone disease. Best Pract Res Clin Gastroenterol. 2006;20(6):981–96.
Stinton LM, Myers RP, Shaffer EA. Epidemiology of gallstones. Gastroenterol Clin N Am. 2010;39(2):157–69. https://doi.org/10.1016/j.gtc.2010.02.003.
Sampliner RE, Bennett PH, Comess LJ, Rose FA, Burch TA. Gallbladder disease in Pima Indians. Demonstration of high prevalence and early onset by cholecystography. N Engl J Med. 1970;283(25):1358–64.
Miquel JF, Covarrubias C, Villaroel L, Mingrone G, Greco AV, Puglielli L, Carvallo P, Marshall G, Del Pino G, Nervi F. Genetic epidemiology of cholesterol cholethiasis among Chilean Hispanics, Amerindians, and Maoris. Gastroenterology. 1998;155:937–46.
Everhart JE. Gallstones and ethnicity in the Americas. J Assoc Acad Minor Phys. 2001;12(3):137–43.
Abdel Bagi M, Arabi M, Abdel Rhaim A, Al Asma A, Gibril M, Mubarak M, Gayium Y, Mirghani S. Prevalence of gallbladder disease in Sudan: first sonographic field study in adult population. Gastroenterology. 1991;100:A307.
Wang DQH, Afdhal NH. Chapter 65 Gallstone disease. In: Sleisenger and Fordtran’s gastrointestinal and liver disease: pathophysiology, diagnosis, management. 10th ed. Canada: Elsevier; 2016. p. 1100–33.
Biss K, Ho KJ, Mikkelson B, Lewis L, Taylor CB. Some unique biologic characteristics of the Masai of East Africa. N Engl J Med. 1971;284(13):694–9.
Lopis S. The incidence of cholelithiasis in the Bantu. Clin Proc. 1947;6(8):338–47.
Salinas G, Velasquez C, Saavedra L, Ramirez E, Angulo H, Tamayo JC, Orellana A, Huivin Z, Valdivia C, Rodriquez W. Prevalence and risk factors for gallstone disease. Surg Laparosc Endosc Percutan Tech. 2004;14:250–3.
Williams CN, Johnston JL, Weldon KLM. Prevalence of gallstones and gallbladder disease in Canadian Micmac Indian women. CMA Journal. 1977;177:758–60.
Everhart JE, Khare M, Hill M, Maurer KR. Prevalence and ethnic differences in gallbladder disease in the United States. Gastroenterology. 1999;117:632–9.
Maurer KR, Everhart JE, Ezzati TM, Johannes RS, Knowler WC, Larson DL, Sanders R, Shawker TH, Roth HP. Prevalence of gallstone disease in Hispanic populations in the United States. Gastroenterology. 1989;96(2):487–92.
Everhart JE, Yeh F, Lee ET, Hill MC, Fabsitz R, Howard BV, Welty TK. Prevalence of gallbladder disease in American Indian populations: findings from the strong heart study. Hepatology. 2002;35:1507–12.
Covarrubias C, Valdivieso V, Nervi F. Epidemiology of gallstone disease in Chile. In: Capocaccia L, Ricci G, Angelico F, Angelico M, Attili AF, editors. Epidemiology and prevention of gallstone disease. Netherlands: Springer; 1984. p. 26–30.
Palermo M, Berkowski DE, Cordoba JP, Verde JM, Gimenez ME. Prevalence of cholelithiasis in Buenos Aires, Argentina. Acta Gastroenterol Latinoam. 2013;43:98–105.
Moro PL, Checkley W, Gilman RH, Cabrera L, Lescano AG, Bonilla JJ, Silva B. Gallstone disease in Peruvian costal natives and highland migrants. Gut. 2000;46:569–73.
Covarrubias C, Miquel JF, Puglielli L, Hofmann E, Giancaspero R, Ebensberger E, Migrone G, Greco A, Buoni C, Nervi F. The role of ethnicity and other risk factors for cholelithiasis in a highly prevalent area: cross sectional and cohort studies in Chileans and Amerindian Araucanos. Gastroenterology. 1995;108(4):A1053.
Cohen H, Antoniello L, Bak M, Kuster E, Martinez I, Caputti S, Fosman E, Zeballos E, Ing Agulla J, Hornblass D, Calvete D. Prevalence of gallbladder lithiasis. Acta Gastroent. 1992;22:107–14.
Coelho JC, Bonilha R, Pitaki SA, Cordeiro RMV, Salvalaggio PRO, Bonin EA, Hahn CG, Soares RV, Milcheski DA. Prevalence of gallstones in a Brazilian population. Int Surg. 1999;84:25–8.
Heaton KW, Braddon FEM, Mountford RA, Hughes AO, Emmett PM. Symptomatic and silent gall stones in the community. Gut. 1991;32:316–20.
Attili AF, De Santis A, Capri R, Repice AM, Maselli S. The natural history of gallstones: the GREPCO experience. Hepatology. 1995;21:656–60.
Barbara L, Sama C, Labate AMM, Taroni F, Rusticali AG, Festi D, Sapio C, Roda E, Banterle C, Puci A, Formentini F, Colasanti S, Nardin F. A population study on the prevalence of gallstone disease: The Sirmione study. Hepatology. 1987;7(5):913–7.
Martinez de Pancorbo C, Carballo F, Horcajo P, Aldeguer M, de la Villa I, Nieto E, Gaspar MJ, de la Morena J. Prevalence and associated factors for gallstone disease: results of a population survey in Spain. J Clin Epidemiol. 1997;50(12):1347–55.
Borch K, Jonsson KA, Zdolsek JM, Halldestam I, Kullman E. Prevalence of gallstone disease in a Swedish population sample: relations to occupation, childbirth, health status, life style, medications, and blood lipids. Scand J Gastroenterol. 1998;33:1219–25.
Kratzer W, Kachele V, Mason RA, Hill V, Hay B, Haug C, Adler G, Beckh K, Muche R. Gallstone prevalence in Germany: the Ulm gallbladder stone study. Dig Dis Sci. 1998;43(6):1285–91.
Volzke H, Baumeister SE, Alte D, Hoffmann W, Schwahn C, Simon P, John U, Lerch MM. Independent risk factors for gallstone formation in a region with high cholelithiasis prevalence. Digestion. 2005;71:97–105.
Thijs C, Knipschild P, Van Engelshoven J. The Prevalence of gallstone disease in a Dutch population. Scand J Gastroenterol. 1990;25:155–60.
Jorgensen T. Prevalence of gallstones in a Danish population. Am J Epidemiol. 1987;126(5):912–21.
Glambek I, Dvaale G, Arnesjo B, Soreide O. Prevalence of gallstones in a Norwegian population. Scand J Gastroenterol. 1987;22(9):1089–94.
Caroli-Bosc FX, Deveau C, Harris A, Delabre B, Peten EP, Hastier P, Sgro E, Caroli-Bosc C, Stoia M, Demarquay JF, Dumas R, Coussement A, Delmont JP. Prevalence of cholelithiasis. Results of an epidemiologic investigation in Vidauban, Southeast France. Dig Dis Sci. 1999;44(7):1322–9.
Reshetnikov OV, Ryabikov AN, Shakhmatov SG, Malyutina SK. Gallstone disease prevalence in Western Siberia: cross-sectional ultrasound study versus autopsy. J Gastroenterol Hepatol. 2002;17:702–7.
Zamani F, Sohrabi M, Alipour A, Motamed N, Saeedian FS, Pirzad R, Abedi K, Maadi M, Ajdarkosh H, Hemmasi G, Khonsari M. Prevalence and risk factors of cholelithiasis in Amol City, Northern Iran: A population based study. Arch Iran Med. 2014;17(11):750–4.
Zeng Q, He Y, Qiang D, Wu L. Prevalence and epidemiological pattern of gallstones in urban residents in China. Eur J Gastroenterol Hepatol. 2012;24:1459–60.
Chen CH, Huang MH, Yang JC, Nien CK, Etheredge GD, Yang CC, Yeh YH, Wu HS, Chou DA, Yueh SK. Prevalence and risk factors of gallstone disease in an adult population of Taiwan: an epidemiological survey. J Gastroenterol Hepatol. 2006;9(12):1737–43.
Nomura H, Kashiwagi S, Hayashi J, Kajiyama W, Ikematsu H, Noguchi A, Tani S, Goto M. Prevalence of gallstone disease in a general population of Okinawa. Jpn Am J Epidemiol. 1988;128(3):598–605.
Chung YJ, Park YD, Lee HC, Cho HJ, Park KS, Seo EH, Jeon SW, Cho CM, Tak WY, Kweon YO, Kim SK, Choi YH, Kim JS, Lee HJ, Chung JM. Prevalence and risk factors of gallstones in a general health screened population. Korean J Med. 2007;72(5):480–90.
Prathnadi P, Miki M, Suprasert S. Incidence of cholelithiasis in the northern part of Thailand. J Med Assoc Thail. 1992;75(8):462–70.
Unisa S, Jagannath P, Dhir V, Khandelwal C, Sarangi L, Roy TK. Population- based study to estimate prevalence and determine risk factors of gallbladder diseases in the rural Gangetic basin of North India. HPB. 2011;13:117–25.
Dhar SC, Ansari SM, Saha M, Ahmad MM, Rahman MT, Hasan M, Khan AKA. Gallstone disease in a rural Bangladeshi community. Indian J Gastroenterol. 2001;20:223–6.
Chapman BA, Frampton CMA, Wilson IR, Chisholm RJ, Allan RB, Burt MJ. Gallstone prevalence in Christchurch: risk factors and clinical significance. NZ Med J. 2000;113:46–8.
Gyedu A, Adae-Aboagye K, Badu-Peprah A. Prevalence of cholelithiasis among person undergoing abdominal ultrasound at the Komfo Anokye Teaching Hospital, Kumasi, Ghana. Afr Health Sci. 2015;15(1):246–52.
Akute OO, Obajimi MO. Cholelithiasis in Ibadan: an update. WAJM. 2002;21(2):128–31.
Walker ARP, Segal I, Posner R, Shein H, Tsotetsi NG, Walker AJ. Prevalence of gallstones in elderly black women in Soweto, Johannesburg, as assessed by ultrasound. Am J Gastroenterol. 1989;84(11):1383–5.
Safer L, Bdioui F, Braham A, Ben Salem K, Soltani MS, Bchir A, Saffar H. Epidemiology of cholelithiasis in central Tunisia. Prevalence and associated factors in a nonselected population. Gastroenterol Clin Biol. 2000;24(10):883–7.
Abu-Eshy SA, Mahfouz AA, Badr A, El Gamal MN, Al-Shehri MY, Salati MI, Rabie ME. Prevalence and risk factors of gallstone disease in a high altitude Saudi population. East Mediterr Health J. 2007;13(4):794.
Peery AF, Dellon ES, Lung J, Crockett SD, Mcgowan CE, Bulsiewicz WJ, Gangarosa LM, Thiny MT, Stizenberg K, Morgan DR, Ringel Y, Kim HP, Dibonaventura MD, Carroll CF, Allen JK, Cook SF, Sandler RS, Kappelman MD, Shaheen NJ. Burden of gastrointestinal disease in the United States: 2012 update. Gastroenterology. 2012;143:1179–87.
Myer PA, Mannalithara A, Singh G, Singh G, Pasricha PJ, Ladabaum U. Clinical and economic burden of emergency department visits due to gastrointestinal diseases in the United States. Am J Gastroenterol. 2013;108:1496–507.
National Institute for Health and Care Excellence. Gallstone disease Quality Standard 104. NHS England. 2015. Webpage on the Internet. www.nice.org.uk/guidance/qs104/resources/gallstone-disease-75545237643973. Accessed 3 Mar 2016
Gurusamy KS, Davidson BR. Clinical review: gallstones. BMJ. 2014;348:g2669.
Crawford JM, Liu C. Liver and biliary tract. In: Kumar V, Abbas AK, Fausto N, Aster JC, editors. Robbins and Cotran pathologic basis of disease. 8th ed. Philadelphia, PA: Saunders Elsevier; 2010. p. 882–90.
Chandran P, Kuchhal NK, Garg P, Pundir CS. An extended chemical analysis of gallstone. Indian J Clin Biochem. 2007;22(2):145–50.
Bonfrate L, Wang DQH, Garruti G, Portincasa P. Obesity and the risk and prognosis of gallstone disease and pancreatitis. Best Pract Res Clin Gastroenterol. 2014;28:623–35.
Lambou-Gianoukos S, Heller SJ. Lithogenesis and bile metabolism. Surg Clin N Am. 2008;88:1175–94.
Trotman BW, Ostrow JD, Soloway RD. Pigment vs cholesterol cholelithiasis: comparison of stone and bile composition. Am J Dig Dis. 1974;19(7):585–90.
Donovan JM. Physical and metabolic factors in gallstone pathogenesis. Gastroenterol Clin N Am. 1999;28(1):75–97.
Admirand WH, Small DM. The physicochemical basis of cholesterol gallstone formation in man. J Clin Invest. 1968;47:1043–52.
Ko CW, Lee SP. Gallstones. In: Yamada T, editor. Atlas of gastroenterology. 4th ed. West Sussex UK: John Wiley & Sons; 2009. p. 1952–77.
Schirmer B, Winters KL, Edlich RF. Cholelithiasis and cholecystitis. J Long-Term Eff Med Implants. 2005;15(3):329–38.
Dooley JS. Gallstones and benign biliary diseases. In: Dooley JS, Lok ASF, Burroughs AK, Heathcote EJ, editors. Sherlock’s diseases of liver and biliary system. 12th ed. UK: Blackwell Publishing Ltd; 2011. p. 257–93.
Bass G, Gilani SNS, Walsh TN. Validating the 5Fs mnemonic for cholelithiasis: time to include family history. Postgrad Med J. 2013;89:638–41.
Stinton LM, Shaffer EA. Epidemiology of gallbladder disease: cholelithiasis and cancer. Gut Liver. 2012;6:172–87.
Bouchier IAD. Formation of gallstones. Keio J Med. 1992;41(1):1–5.
Acalovschi M. Cholesterol gallstones: from epidemiology to prevention. Postgrad Med J. 2001;77:|221–9.
Lyons MA, Wittenburg H. Cholesterol gallstone susceptibility loci: a mouse map, candidate gene evaluation, and guide to human LITH genes. Gastroenterology. 2006;131:1943–70.
Wang HH, Portincasa P, Afdhal NH, Wang DQH. Lith genes and genetic analysis of cholesterol gallstone formation. Gastroenterol Clin N Am. 2010;39:185–207.
Society of American Gastrointestinal and Endoscopic Surgeons (SAGES). SAGES guidelines for the clinical application of laparoscopic biliary tract surgery. 2010. Society of American Gastrointestinal and Endoscopic Surgeons (SAGES), Los Angeles, CA. http://www.sages.org/publications/guidelines/guidelines-for-the-clinical-application-of-laparoscopic-biliary-tract-surgery/.
National Institute for Health and Care Excellence. Gallstone disease. (homepage on the Internet). 2014 (cited 2015 Sep 10). National Institute for Health and Care Excellence. http://www.nice.org.uk/guidance/cg188/resources/guidance-gallstone-disease-pdf.
Cafasso DE, Smith RR. Functional disorders of the biliary tract. Surg Clin N Am. 2014;94:233–56.
Salman B, Yuksel O, Irkorucu O, Akyurek N, Tezcaner T, Dogan I, Erdem O, Tatlicioglu E. Urgent laparoscopic cholecystectomy is the best management for biliary colic. Dig Surg. 2005;22:95–9.
Berger MY, olde Hartman TC, Bohnen AM. Abdominal symptoms: do they disappear after cholecystectomy? Surg Endosc. 2003;17:1723–8.
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Cao, A.M., Eslick, G.D. (2018). Epidemiology and Pathogenesis of Gallstones. In: Cox, M., Eslick, G., Padbury, R. (eds) The Management of Gallstone Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-63884-3_3
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