Bizzarri M, Fuso A, Dinicola S et al (2016) Pharmacodynamics and pharmacokinetics of inositol(s) in health and disease. Expert Opin Drug Metab Toxicol 12(10):1181–1196
CAS
CrossRef
PubMed
Google Scholar
Vucenik I, Tantivejkul K, Ramakrishna G et al (2005) Inositol hexaphosphate (IP6) blocks proliferation of breast cancer cells through PKCδ-dependent increase in p27Kip1 and decrease in retinoblastoma protein (pRb) phosphorylation. Breast Cancer Res Treat 91:35–45
CAS
CrossRef
PubMed
Google Scholar
Shamsuddin AM, Yang GY, Vucenik I (1996) Novel anti-cancer functions of IP6: growth inhibition and differentiation of human mammary cancer cell lines in vitro. Anticancer Res 16:3287–3292
CAS
PubMed
Google Scholar
Vucenik I, Kalebic T, Tantivejkul K et al (1998b) Novel anticancer function of inositol hexaphosphate: inhibition of human rhabdomyosarcoma in vitro and in vivo. Anticancer Res 18:1377–1384
CAS
PubMed
Google Scholar
Ferry S, Matsuda M, Yoshida H, Hirata M (2002) Inositol hexakisphosphate blocks tumor cell growth by activating apoptotic machinery as well as by inhibiting the Akt/NFkB-mediated cell survival pathway. Carcinogenesis 23:2031–2041
CAS
CrossRef
PubMed
Google Scholar
Tantivejkul K, Vucenik I, Eiseman J et al (2003) Inositol hexaphosphate (IP6) enhances the anti-proliferative effects of adriamycin and tamoxifen in breast cancer. Breast Cancer Res Treat 79:301–312
CAS
CrossRef
PubMed
Google Scholar
Vucenik I, Shamsuddin AM (2003) Cancer inhibition by inositol hexaphosphate (IP6) and inositol: from laboratory to clinic. J Nutr 133:3778S–3784S
CAS
CrossRef
PubMed
Google Scholar
Sakamoto K, Venkatraman G, Shamsuddin AM (1993) Growth inhibition and differentiation of HT-29 cells in vitro by inositol hexaphosphate (phytic acid). Carcinogenesis 14:1815–1819
CAS
CrossRef
PubMed
Google Scholar
Yang GY, Shamsuddin AM (1995) IP6-induced growth inhibition and differentiation of HT-29 human colon cancer cells: involvement of intracellular inositol phosphates. Anticancer Res 15:2479–2487
CAS
PubMed
Google Scholar
Pittet D, Schlegel W, Lew DP et al (1989) Mass changes in inositol tetrakis- and pentakisphosphate isomers induced by chemotactic peptide stimulation in HL-60 cells. J Biol Chem 264:18489–18493
CAS
PubMed
Google Scholar
Weglarz L, Molin I, Orchel A et al (2006) Quantitative analysis of the level of p53 and p21WAF1 mRNA in human colon cancer HT-29 cells treated with inositol hexaphosphate. Acta Biochim Pol 53(2):349–356
CAS
PubMed
Google Scholar
Roy S, Gu M, Ramasamy K et al (2009) p21/Cip1 and p27/Kip1 are essential molecular targets of inositol hexaphosphate for its antitumor efficacy against prostate cancer. Cancer Res 69(3):1166–1173
CAS
CrossRef
PubMed
PubMed Central
Google Scholar
Zhang Z, Liu Q, Lantry LE et al (2000) Germ-line p53 mutation accelerates pulmonary tumorigenesis: p53-independent efficacy of chemopreventive agents green tea or dexamethasone/myo -inositol and chemotherapeutic agents taxol or adriamycin. Cancer Res 60(4):901–907
CAS
PubMed
Google Scholar
Koguchi T, Tanikawa C, Mori J et al (2016) Regulation of myo-inositol biosynthesis by p53-ISYNA1 pathway. Int J Oncol 48(6):2415–2424
CAS
CrossRef
PubMed
Google Scholar
Diallo JS, Betton B, Parent N et al (2008) Enhanced killing of androgen independent prostate cancer cells using inositol hexakisphosphate in combination with proteasome inhibitors. Br J Cancer 99:1613–1622
CAS
CrossRef
PubMed
PubMed Central
Google Scholar
Beckonert O, Monnerjahn J, Bonk U et al (2003) Visualizing metabolic changes in breast-cancer tissue using 1H-NMR spectroscopy and self-organizing maps. NMR Biomed 16(1):1–11
CAS
CrossRef
PubMed
Google Scholar
Liu G, Song Y, Cui L et al (2015) Inositol hexakisphosphate suppresses growth and induces apoptosis in HT-29 colorectal cancer cells in culture: PI3K/Akt pathway as a potential target. Int J Clin Exp Pathol 8(2):1402–1410
CAS
PubMed
PubMed Central
Google Scholar
Huang C, Ma W, Hecht SS et al (1997) Inositol hexaphosphate inhibits cell transformation and activator protein 1 activation by targeting phosphatidylinositol-3′ kinase. Cancer Res 57:2873–2878
CAS
PubMed
Google Scholar
Dinicola S, Fabrizi G, Masiello MG et al (2016) Inositol induces mesenchymal-epithelial reversion in breast cancer cells through cytoskeleton rearrangement. Exp Cell Res 345(1):37–50
CAS
CrossRef
PubMed
Google Scholar
Gu M, Roy S, Raina K et al (2009) Inositol hexaphosphate suppresses growth and induces apoptosis in prostate carcinoma cells in culture and nude mouse xenograft: PI3K-Akt pathway as potential target. Cancer Res 69(24):9465–9472
CAS
CrossRef
PubMed
PubMed Central
Google Scholar
Han W, Gills JJ, Memmott RM et al (2009) The chemopreventive agent myoinositol inhibits Akt and extracellular signal-regulated kinase in bronchial lesions from heavy smokers. Cancer Prev Res 2(4):370–376
CAS
CrossRef
Google Scholar
Vucenik I, Tomazic VJ, Fabian D et al (1992) Antitumor activity of phytic acid (inositol hexaphosphate) in murine transplanted and metastatic fibrosarcoma, a pilot study. Cancer Lett 65:9–13
CAS
CrossRef
PubMed
Google Scholar
Tantivejkul K, Vucenik I, Shamsuddin AM (2003) Inositol hexaphosphate (IP6) inhibits key events of cancer metastases: I. In vitro studies of adhesion, migration and invasion of MDA--MB 231 human breast cancer cells. Anticancer Res 23:3671–3679
CAS
PubMed
Google Scholar
Luu HH, Zhang R, Haydon RCC et al (2004) Wnt/𝛽-catenin signaling pathway as novel cancer drug targets. Curr Cancer Drug Targets 4(8):653–671
Google Scholar
Shafie NH, Mohd Esa N, Ithnin H et al (2013) Preventive inositol hexakisphosphate extracted from rice bran inhibits colorectal cancer through involvement of Wnt/𝛽-catenin and COX-2 pathways. Biomed Res Int 2013:681027
Google Scholar
Liao J, Seril DN, Yang AL et al (2007) Inhibition of chronic ulcerative colitis associated adenocarcinoma development in mice by inositol compounds. Carcinogenesis 28:446–454
CAS
CrossRef
PubMed
Google Scholar
Kamp DW, Israbian VA, Yeldandi AV et al (1995) Phytic acid, an iron chelator, attenuates pulmonary inflammation and fibrosis in rats after intratracheal instillation of asbestos. Toxicol Pathol 23:689–695
CAS
CrossRef
PubMed
Google Scholar
Weglarz L, Wawszczyk J, Orchel A et al (2007) Phytic acid modulates in vitro IL-8 and IL-6 release from colonic epithelial cells stimulated with LPS and IL-1beta. Dig Dis Sci 52:93–102
CAS
CrossRef
PubMed
Google Scholar
Couchman JR, Vogt S, Lim ST et al (2002) Regulation of inositol phospholipid binding and signaling through syndecan-4. J Biol Chem 277:49296–49303
CAS
CrossRef
PubMed
Google Scholar
Morrison RS, Shi E, Kan M et al (1994) Inositol hexakisphosphate (InsP6): an antagonist of fibroblast growth factor receptor binding and activity. In Vitro Cell Dev Biol Anim 30A(11):783–789
CAS
CrossRef
PubMed
Google Scholar
Vucenik I, Passaniti A, Vitolo MI et al (2004) Anti-angiogenic potential of inositol hexaphosphate (IP6). Carcinogenesis 25:2115–2123
CAS
CrossRef
PubMed
Google Scholar
Kar S, Quirion R, Parent A (1994) An interaction between inositol hexakisphosphate (IP6) and insulin-like growth factor II receptor binding sites in the rat brain. Neuroreport 5:625–628
CAS
CrossRef
PubMed
Google Scholar
D’Anna R, Di Benedetto A, Scilipoti A et al (2015) Myo-inositol supplementation for prevention of gestational diabetes in obese pregnant women: a randomized controlled trial. Obstet Gynecol 126(2):310–315
CrossRef
PubMed
Google Scholar
Graf E, Eaton JW (1990) Antioxidant functions of phytic acid. Free Radic Biol Med 8:61–69
CAS
CrossRef
PubMed
Google Scholar
Rao PS, Liu XK, Das DK et al (1991) Protection of ischemic heart from reperfusion injury by myo-inositol hexakisphosphate, a natural antioxidant. Ann Thorac Surg 52:908–912
CAS
CrossRef
PubMed
Google Scholar
Porres JM, Stahl CH, Cheng WH et al (1999) Dietary intrinsic phytate protects colon from lipid peroxidation in pigs with a moderately high dietary iron intake. Proc Soc Exp Biol Med 221:80–86
CAS
CrossRef
PubMed
Google Scholar
Druzijanic N, Juricic J, Perko Z et al (2002) IP-6 and inositol: adjuvant to chemotherapy of colon cancer. A pilot clinical trial. Rev Oncol 4:171
Google Scholar
Bacić I, Druzijanić N, Karlo R et al (2010) Efficacy of IP6 + inositol in the treatment of breast cancer patients receiving chemotherapy: prospective, randomized, pilot clinical study. J Exp Clin Cancer Res 29:12
Google Scholar
Lam S, McWilliams A, LeRiche J et al (2006) A phase I study of myo-inositol for lung cancer chemoprevention. Cancer Epidemiol Biomark Prev 15(8):1526–1531
CAS
CrossRef
Google Scholar
Fu M, Song Y, Wen Z et al (2016) Inositol hexaphosphate and inositol inhibit colorectal cancer metastasis to the liver in BALB/c mice. Forum Nutr 8(5):E286
Google Scholar