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Classification of Hub Protein and Analysis of Hot Regions in Protein-Protein Interactions

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Intelligent Computing Theories and Application (ICIC 2017)

Part of the book series: Lecture Notes in Computer Science ((LNISA,volume 10362))

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Abstract

Proteins are fundamental to most biological processes, which accomplish a vast amount of functions by interacting with other proteins. The research of PPI (protein-protein interaction) and its network has developed into a great importance part in bioinformatics. In the protein-protein interaction networks, most proteins interact with only a few partners, and small number of proteins interact with many partners, these proteins are called hub proteins. The hub proteins can be divided into party hub and date hub. Therefore, in this paper, we do some works about hub proteins. In addition, this paper uses the connectivity and betweenness to classify the hub protein in protein-protein interaction network. On the other hand, the paper studies hub proteins from another perspective (interfaces conformation), which reflects the organization of hot spot residues in hub protein interface.

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Acknowledgment

The authors thank the members of Machine Learning and Artificial Intelligence Laboratory, School of Computer Science and Technology, Wuhan University of Science and Technology, for their helpful discussion within seminars. This work was supported in part by National Natural Science Foundation of China (No. 61502356, 61273225, 61273303).

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Authors and Affiliations

  1. Hubei Key Laboratory of Intelligent Information Processing and Real-Time Industrial System, School of Computer Science and Technology, Wuhan University of Science and Technology, Wuhan, 430065, China

    Xiaoli Lin, Xiaolong Zhang & Jing Hu

  2. Information and Engineering Department of City College, Wuhan University of Science and Technology, Wuhan, 430083, China

    Xiaoli Lin

Authors
  1. Xiaoli Lin
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  2. Xiaolong Zhang
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  3. Jing Hu
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Correspondence to Xiaolong Zhang .

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Editors and Affiliations

  1. Tongji University, Shanghai, China

    De-Shuang Huang

  2. University of Ulsan, Ulsan, Korea (Republic of)

    Kang-Hyun Jo

  3. Universidad Distrital Francisco José de Caldas, Bogotá, Colombia

    Juan Carlos Figueroa-García

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Lin, X., Zhang, X., Hu, J. (2017). Classification of Hub Protein and Analysis of Hot Regions in Protein-Protein Interactions. In: Huang, DS., Jo, KH., Figueroa-García, J. (eds) Intelligent Computing Theories and Application. ICIC 2017. Lecture Notes in Computer Science(), vol 10362. Springer, Cham. https://doi.org/10.1007/978-3-319-63312-1_32

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  • DOI: https://doi.org/10.1007/978-3-319-63312-1_32

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-63311-4

  • Online ISBN: 978-3-319-63312-1

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