Emergent Behaviour in T Cell Immune Response

  • Clemente F. Arias
  • Miguel A. Herrero
Conference paper
Part of the Mathematics in Industry book series (MATHINDUSTRY, volume 26)


The ability of our immune system to fight off challenges posed by pathogenic agents (external or internal) is amazing. Indeed, many times during a normal lifespan immune cells have to identify and destroy incoming threats while leaving harmless cell trafficking undisturbed. Most remarkably, this careful regulation of body function is achieved in the absence of any organ in charge of controlling immune response. The latter is just an emergent property resulting from a very limited number of individual actions taken by immune cells, using only local information from their immediate neighbourhood. We shortly review here some striking aspects of this emergent behaviour. In particular, we will focus our attention on two issues, namely the way immune system regulates the number of effector T cells required to wipe out an acute infection and the mechanisms to distinguish friends from foes upon inspection of circulating antigens.



This work has been partially supported by MINECO Grant MTM2014-53156-P.


  1. 1.
    Arias, C.F., Herrero, M.A., Acosta, F.J., Fernandez-Arias, C.: A mathematical model for a T cell fate decision algorithm during immune response. J. Theor. Biol. 349, 109–120 (2014)MathSciNetCrossRefGoogle Scholar
  2. 2.
    Arias, C.F., Herrero, M.A., Cuesta, J.A., Acosta, F.J., Fernandez-Arias, C.: The growth threshold conjecture: a theoretical framework for understanding T-cell tolerance. R. Soc. Open Sci. 2(7), 150016 (2015)CrossRefGoogle Scholar
  3. 3.
    Czabotar, P.E., Lessene, G., Strasser, A., Adams, J.M.: Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy. Nat. Rev. Mol. Cell Biol. 15(1), 49–63 (2014)CrossRefGoogle Scholar
  4. 4.
    Giacinti, C., Giordano, A.: RB and cell cycle progression. Oncogene 25(38), 5220–5227 (2006)CrossRefGoogle Scholar
  5. 5.
    Janeway Jr., C.A., Travers, P., Walport, M.: Immunobiology: The Immune System in Health and Disease. Garland Science, New York (2014)Google Scholar
  6. 6.
    Matzinger, P.: Tolerance, danger, and the extended family. Annu. Rev. Immunol. 12, 991–1045 (1994). doi:10.1146/annurev.iy.12.040194.005015CrossRefGoogle Scholar
  7. 7.
    Sompayrac, L.M.: How the Immune System Works. John Wiley & Sons, Hoboken, NJ (2015)Google Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2017

Authors and Affiliations

  1. 1.Grupo Interdisciplinar de Sistemas ComplejosMadridSpain
  2. 2.Departamento de Matemática Aplicada, Facultad de MatemáticasUniversidad Complutense de MadridMadridSpain

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