PRRT with Radiolabeled Peptides: Indications, Procedures, and Results

  • Ettore Seregni
  • Alice Lorenzoni


Peptide receptor radionuclide therapy (PRRT) is an effective and usually well-tolerated treatment for unresectable or metastatic neuroendocrine tumors expressing somatostatin receptors. The two radiopharmaceuticals most commonly used for PRRT are 90Y-DOTATOC and 177Lu-DOTATATE which have been demonstrated to provide effective tumor response and symptom relief and have positive impact on survival. Chronic side effects on the kidneys and bone marrow are generally mild. Future perspectives include combinations with innovative therapeutic agents or the use of alpha-emitting radionuclide to improve PRRT efficacy.


Peptide receptor radionuclide therapy (PRRT) Neuroendocrine tumor 90Y/177Lu-DOTATOC-DOTATATE 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Nuclear MedicineFondazione IRCCS Istituto Nazionale TumoriMilanItaly

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