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Zinc, Insulin and IGF-I Interplay in Aging

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Hormones in Ageing and Longevity

Part of the book series: Healthy Ageing and Longevity ((HAL,volume 6))

Abstract

Zn plays an important part in many biological processes including the insulin- and insulin growth factor (IGF) signaling (IIS) pathway which, in turn, is an evolutionary conserved pathway involved in many functions that are necessary for metabolism and growth. Notably, the IIS pathway play also a major role in aging. The overall cellular response and the outcome on the longevity of the organism depends also by the mechanisms involved in the regulation of Zn homeostasis that need to act in synergy just like a symphony orchestra. A likely conductor of this orchestra is the IIS pathway, which in turn is affected itself by the different ability to modulate Zn homeostasis of each cell within the tissues. The multiple ways by which Zn action affects insulin and IGF-1 activities and how these hormones modulate Zn homeostasis is reviewed in this chapter. While the mutual interaction between Zn and IIS on the modulation of longevity appears to be still unclear and characterized by contradictory findings, there is consistent support to draw a picture where a functional cell is able to disentangle IIS-mediated “nutritional Zn signals”, which activate growth promoting pathways, functional integrity and cell division, from “stress response Zn signals” which, in turn, activate a cascade of signals to regulate transcriptionally and post-transcriptionally a multitude of cellular functions that include oxidative stress responses and the secretion of soluble factors.

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Supplementary Data

  • Full link to the STRING NETWORKS described in Fig. 4.2. Copy and paste the URL to see interactive and high resolution picture.

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  1. Scientific and Technological Pole INRCA, via Birarelli 8, 60121, Ancona, Italy

    Marco Malavolta, Francesco Piacenza, Laura Costarelli, Maurizio Cardelli, Eugenio Mocchegiani, Andrea Basso, Elisa Pierpaoli, Mauro Provinciali & Robertina Giacconi

  2. Department of Clinical and Molecular Sciences, Polytechnic University of Marche, 60020, Ancona, Italy

    Lory Santarelli

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  1. Marco Malavolta
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    Suresh Rattan

  2. Department of Biochemistry, North Eastern Hill University, Shillong, Megalaya, India

    Ramesh Sharma

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Malavolta, M. et al. (2017). Zinc, Insulin and IGF-I Interplay in Aging. In: Rattan, S., Sharma, R. (eds) Hormones in Ageing and Longevity. Healthy Ageing and Longevity, vol 6. Springer, Cham. https://doi.org/10.1007/978-3-319-63001-4_4

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