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Precision Molecular Pathology of Lung Cancer pp 239–255Cite as

Targeted Therapies for Lung Cancer

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Abstract

The impressive advances in understanding the genomic changes driving many lung carcinomas, especially adenocarcinomas, have led to a growing number of small-molecule drugs that often have meaningful clinical activity against advanced cancer. In many cases, therapy selected on the basis on a driver mutation has considerably more activity than standard cytotoxic chemotherapy. However for patients to receive the full potential benefit of this knowledge, the correct testing must be performed to identify those likely to benefit from targeted therapy. This chapter will review the current field of targeted agents for advanced lung cancer, the methods of identification of the genomic mutations, the corresponding clinical features, and the activity of particular agents that have been approved or about to be approved for use in patients.

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Authors and Affiliations

  1. Cancer Center, Houston Methodist Hospital, Houston, TX, USA

    Asmita Patel MD & Eric H. Bernicker MD

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  1. Asmita Patel MD
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  2. Eric H. Bernicker MD
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Correspondence to Eric H. Bernicker MD .

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Editors and Affiliations

  1. Department of Pathology & Genomic Medici, Houston Methodist Hospital, Houston, Texas, USA

    Philip T. Cagle

  2. Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA

    Timothy Craig Allen

  3. Department of Pathology, Mount Sinai Medical Center, New York, New York, USA

    Mary Beth Beasley

  4. Department of Pathology, Brigham & Women’s Hospital, Boston, Massachusetts, USA

    Lucian R. Chirieac

  5. Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

    Sanja Dacic

  6. Department of Pathology, Weill Cornell Medicine, New York, New York, USA

    Alain C. Borczuk

  7. Department of Pathology, Aberdeen University Medical School, Aberdeen, United Kingdom

    Keith M. Kerr

  8. Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA

    Lynette M. Sholl

  9. Medical Innovation, Roche Tissue Diagnostics, Ventana Medical Systems, Tucson, Arizona, USA

    Bryce Portier

  10. Cancer Center, Houston Methodist Hospital, Houston, Texas, USA

    Eric H. Bernicker

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Patel, A., Bernicker, E.H. (2018). Targeted Therapies for Lung Cancer. In: Cagle, P., et al. Precision Molecular Pathology of Lung Cancer. Molecular Pathology Library. Springer, Cham. https://doi.org/10.1007/978-3-319-62941-4_19

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