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Neoadjuvant Treatment in Breast Cancer

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Oncoplastic and Reconstructive Breast Surgery

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Abstract

Neoadjuvant (preoperative) therapy, initially developed to render primary inoperable tumors, is increasingly being delivered in patients with smaller lesions and particularly in patients with human epidermal growth factor receptor 2 (HER2)-positive and triple-negative breast cancer (TNBC). The neoadjuvant approach offers the advantages of downstaging the tumor and axilla, allowing for less extensive surgery, reducing postoperative complications, and evaluating the efficacy of therapy in vivo. Pathologic complete response (pCR) has been accepted as a primary endpoint in a number of neoadjuvant trials. This chapter provides a summary of the knowledge gained thus far from neoadjuvant trials conducted in breast cancer and discusses the current treatment recommendations and future research and trends.

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Abbreviations

BCS:

Breast-conserving surgery

DFS:

Disease-free survival

EFS:

Event-free survival

ER:

Estrogen receptor

HER2:

Human epidermal growth factor receptor 2

HR:

Hormonal receptor

HRD:

Homologous recombination deficiency

OR:

Odds ratios

OS:

Overall survival

pCR:

Pathologic complete response

RR:

Clinical response rate

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Conflict of Interest

Rui Wang has no conflict no interest.

Chau Dang has research funding through Roche/Genentech and GlaxoSmithKline.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Authors and Affiliations

  1. Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Rui Wang

  2. Westchester Medical Oncology Service, Breast Medicine Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Chau Dang

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  1. Rui Wang
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  2. Chau Dang
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Corresponding author

Correspondence to Chau Dang .

Editor information

Editors and Affiliations

  1. Our Lady of Grace Hospital, Positivo University, Curitiba, Brazil

    Cicero Urban

  2. Plastic and Reconstructive Division, European Institute of Oncology, Milan, Italy

    Mario Rietjens

  3. Memorial Sloan Kettering Cancer Center, New York, USA

    Mahmoud El-Tamer

  4. Memorial Sloan Kettering Cancer Center, New York, USA

    Virgilio S. Sacchini

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Wang, R., Dang, C. (2019). Neoadjuvant Treatment in Breast Cancer. In: Urban, C., Rietjens, M., El-Tamer, M., Sacchini, V.S. (eds) Oncoplastic and Reconstructive Breast Surgery. Springer, Cham. https://doi.org/10.1007/978-3-319-62927-8_12

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  • DOI: https://doi.org/10.1007/978-3-319-62927-8_12

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