Cancer of the Lip and Oral Cavity
This chapter will discuss the epidemiology, workup, and management of oral cavity cancer, with an emphasis on radiation therapy technique (including brachytherapy) and randomized trial evidence.
KeywordsOral cavity cancer Radiation therapy Brachytherapy Chemoradiotherapy Osteoradionecrosis Lip Gingiva Retromolar trigone Buccal mucosa Floor of mouth Oral tongue
We thank Eric K. Hansen MD, Sue S. Yom MD, Chien Peter Chen MD, and Naomi R. Schechter MD, for their work on the prior edition of this chapter.
- Iyer NG, Tan DSW, Tan VK, et al. Randomized trial comparing surgery and adjuvant radiotherapy versus concurrent chemoradiotherapy in patients with advanced, nonmetastatic squamous cell carcinoma of the head and neck: 10-year update and subset analysis. Cancer. 2015;121(10):1599–607.CrossRefPubMedGoogle Scholar
- Kovács G, Martinez-Monge R, Budrukka A, et al. GEC-ESTRO ACROP recommendations for head & neck brachytherapy in squamous cell carcinomas: 1st update – improvement by cross sectional imaging based treatment planning and stepping source technology. Radiother Oncol. 2016;122(2):248–54.CrossRefPubMedGoogle Scholar
- Laskar SG, Chaukar D, Deshpande M, et al. Phase III randomized trial of surgery followed by conventional radiotherapy (5 fr/Wk) (Arm A) vs concurrent chemoradiotherapy (arm B) vs accelerated radiotherapy (6fr/Wk) (Arm C) in locally advanced, stage III and IV, resectable, squamous cell carcinoma of oral cavity- oral cavity adjuvant therapy (OCAT): final results (NCT00193843). J Clin Oncol. 2016;34(suppl; abstr 6004).Google Scholar