Cancer of the Lip and Oral Cavity

Chapter

Abstract

This chapter will discuss the epidemiology, workup, and management of oral cavity cancer, with an emphasis on radiation therapy technique (including brachytherapy) and randomized trial evidence.

Keywords

Oral cavity cancer Radiation therapy Brachytherapy Chemoradiotherapy Osteoradionecrosis Lip Gingiva Retromolar trigone Buccal mucosa Floor of mouth Oral tongue 

Notes

Acknowledgment

We thank Eric K. Hansen MD, Sue S. Yom MD, Chien Peter Chen MD, and Naomi R. Schechter MD, for their work on the prior edition of this chapter.

References

  1. Ang KK, Trotti A, Brown BW, et al. Randomized trial addressing risk features and time factors of surgery plus radiotherapy in advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2001;51:571–8.CrossRefGoogle Scholar
  2. D’Cruz AK, Vaish R, Kapre N, et al. Elective versus therapeutic neck dissection in node-negative oral cancer. N Engl J Med. 2015;373(6):521–9.CrossRefGoogle Scholar
  3. Grabenbauer GG, Rodel C, Brunner T, et al. Interstitial brachytherapy with Ir-192 low-dose-rate in the treatment of primary and recurrent cancer of the oral cavity and oropharynx. Review of 318 patients treated between 1985 and 1997. Strahlenther Onkol. 2001;177:338–44.CrossRefGoogle Scholar
  4. Iyer NG, Tan DSW, Tan VK, et al. Randomized trial comparing surgery and adjuvant radiotherapy versus concurrent chemoradiotherapy in patients with advanced, nonmetastatic squamous cell carcinoma of the head and neck: 10-year update and subset analysis. Cancer. 2015;121(10):1599–607.CrossRefGoogle Scholar
  5. Kovács G, Martinez-Monge R, Budrukka A, et al. GEC-ESTRO ACROP recommendations for head & neck brachytherapy in squamous cell carcinomas: 1st update – improvement by cross sectional imaging based treatment planning and stepping source technology. Radiother Oncol. 2016;122(2):248–54.CrossRefGoogle Scholar
  6. Kramer S, Gelber RD, Snow JB, et al. Combined radiation therapy and surgery in the management of advanced head and neck cancer: final report of study 73-03 of the Radiation Therapy Oncology Group. Head Neck Surg. 1987;10:19–30.CrossRefGoogle Scholar
  7. Laskar SG, Chaukar D, Deshpande M, et al. Phase III randomized trial of surgery followed by conventional radiotherapy (5 fr/Wk) (Arm A) vs concurrent chemoradiotherapy (arm B) vs accelerated radiotherapy (6fr/Wk) (Arm C) in locally advanced, stage III and IV, resectable, squamous cell carcinoma of oral cavity- oral cavity adjuvant therapy (OCAT): final results (NCT00193843). J Clin Oncol. 2016;34(suppl; abstr 6004).Google Scholar
  8. Martinez-Monge R, Gomez-Iturriaga A, Cambeiro M, et al. Phase I-II trial of perioperative high-dose-rate brachytherapy in oral cavity and oropharyngeal cancer. Brachytherapy. 2009;8:26–33.CrossRefGoogle Scholar
  9. Mazeron JJ, Ardiet JM, Haie-Méder C, et al. GEC-ESTRO recommendations for brachytherapy for head and neck squamous cell carcinomas. Radiother Oncol. 2009;91(2):150–6.CrossRefGoogle Scholar
  10. Melzner WJ, Lotter M, Sauer R, et al. Quality of interstitial PDR brachytherapy-implants of head-and-neck-cancers: predictive factors for local control and late toxicity? Radiother Oncol. 2007;82:167–73.CrossRefGoogle Scholar
  11. Nag S, Cano ER, Demanes DJ, et al. The American Brachytherapy Society recommendations for high-dose-rate brachytherapy for head-and-neck carcinoma. Int J Radiat Oncol Biol Phys. 2001;50(5):1190–8.CrossRefGoogle Scholar
  12. Peters LJ, Goepfert H, Ang KK, et al. Evaluation of the dose for postoperative radiation therapy of head and neck cancer: first report of a prospective randomized trial. Int J Radiat Oncol Biol Phys. 1993;26(1):3–11.CrossRefGoogle Scholar
  13. Strnad V, Lotter M, Kreppner S, Fietkau R. Reirradiation for recurrent head and neck cancer with salvage interstitial pulsed-dose-rate brachytherapy: long-term results. Strahlenther Onkol. 2015;191(6):495–500.CrossRefGoogle Scholar
  14. Tupchong L, Scott CB, Blitzer PH, et al. Randomized study of preoperative versus postoperative radiation therapy in advanced head and neck carcinoma: long-term follow-up of RTOG study 73-03. Int J Radiat Oncol Biol Phys. 1991;20:21–8.CrossRefGoogle Scholar
  15. Wendt CD, Peters LJ, Delclos L, et al. Primary radiotherapy in the treatment of stage I and II oral tongue cancers: importance of the proportion of therapy delivered with interstitial therapy. Int J Radiat Oncol Biol Phys. 1990;18(6):1287–92.CrossRefGoogle Scholar
  16. Zhong LP, Zhang CP, Ren GX, et al. Randomized phase III trial of induction chemotherapy with docetaxel, cisplatin, and fluorouracil followed by surgery versus up-front surgery in locally advanced resectable oral squamous cell carcinoma. J Clin Oncol. 2013;31:744–51.CrossRefGoogle Scholar
  17. Zhong LP, Zhang CP, Ren GX, et al. Long-term results of a randomized phase III trial of TPF induction chemotherapy followed by surgery and radiation in locally advanced oral squamous cell carcinoma. Oncotarget. 2015;6(21):18707–14.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Radiation OncologyUniversity of California San FranciscoSan FranciscoUSA
  2. 2.Radiation OncologyUniversity of Southern CaliforniaLos AngelesUSA

Personalised recommendations