Skip to main content

Radiation Related Cardiovascular Disease

  • Chapter
  • First Online:
Cancer and Cardiovascular Disease
  • 592 Accesses

Abstract

Cardiovascular disease, is a well known complication of radiation therapy. This is especially seen in Hogdkin’s lymphoma survivors, who have received mediastinal therapy.

In this chapter, we present some of the common conditions associated with radiation induced heart disease.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

References

  1. American Cancer Society. Cancer treatment and survivorship facts & figures 2014–2015. 2014. http://www.cancer.org/

  2. Yusuf SW, Sami S, Daher IN. Radiation-induced heart disease: a clinical update. Cardiol Res Pract. 2011;2011:317659. doi:10.4061/2011/317659.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Ng AK, Bernardo MP, Weller E, et al. Long-term survival and competing causes of death in patients with early-stage Hodgkin’s disease treated at age 50 or younger. J Clin Oncol. 2002;20(8):2101–8.

    Article  PubMed  Google Scholar 

  4. Hancock SL, Tucker MA, Hoppe RT. Factors affecting late mortality from heart disease after treatment of Hodgkin’s disease. JAMA. 1993;270(16):1949–55.

    Article  CAS  PubMed  Google Scholar 

  5. Mulroney DA, Easel MW, Kawashima T, et al. Cardiac outcomes in a cohort of adult survivors of childhood and adolescent cancer: retrospective analysis of the childhood cancer survivor study cohort. BMJ. 2009;339:b4606.

    Article  Google Scholar 

  6. Swerdlow AJ, Higgins CD, Smith P, et al. Myocardial infarction mortality risk after treatment for Hodgkin disease: a collaborative British cohort study. J Natl Cancer Inst. 2007;99(3):206–14.

    Article  PubMed  Google Scholar 

  7. Cuzick J, Stewart H, Rutqvist L, et al. Cause-specific mortality in long-term survivors of breast cancer who participated in trials of radiotherapy. J Clin Oncol. 1994;12(3):447–53.

    Article  CAS  PubMed  Google Scholar 

  8. Galper SL, Yu JB, Mauch PM, et al. Clinically significant cardiac disease in patients with Hodgkin lymphoma treated with mediastinal irradiation. Blood. 2011;17(2):412–8.

    Article  CAS  Google Scholar 

  9. Stone HB, Coleman CN, Anscher MS, McBride WH. Effects of radiation on normal tissue: consequences and mechanisms. Lancet Oncol. 2003;4:529–3.

    Article  CAS  PubMed  Google Scholar 

  10. Hardenberg PH, Munley MT, Bentel GC, et al. Cardiac perfusion changes in patients treated for breast cancer with radiation therapy and doxorubicin; preliminary results. Int J Radiation Oncol Biol Phys. 2001;49(4):1023–8.

    Article  Google Scholar 

  11. Heidenreich PA, Hancock SL, Lee BK, Mariscal CS, Schnittger I. Asymptomatic cardiac disease following mediastinal irradiation. J Am Coll Cardiol. 2003;42(4):743–9.

    Article  PubMed  Google Scholar 

  12. Thavendiranathan P, Poulin F, Lim KD, et al. Use of myocardial strain imaging by echocardiography for the early detection of cardiotoxicity in patients during and after cancer chemotherapy: a systematic review. J Am Coll Cardiol. 2014;63(25 Pt A):2751–68. doi:10.1016/j.jacc.2014.01.073. Epub 2014 Apr 2

    Article  PubMed  Google Scholar 

  13. Brosius FC 3rd, Waller BF, Roberts WC. Radiation heart disease. Analysis of 16 young (aged 15 to 33 years) necropsy patients who received over 3,500 rads to the heart. Am J Med. 1981;70(3):519–30.

    Article  PubMed  Google Scholar 

  14. Orzan F, Brusca A, Conte MR, Presbitero P, Figliomeni MC. Severe coronary artery disease after radiation therapy of the chest and mediastinum: clinical presentation and treatment. Br Heart J. 1993;69(6):496–500.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Gyenes G, Fornander T, Carlens P, Glas U, Rutqvist LE. Myocardial damage in breast cancer patients treated with adjuvant radiotherapy: a prospective study. Int J Radiat Oncol Biol Phys. 1996;36(4):899–905.

    Article  CAS  PubMed  Google Scholar 

  16. Heidenreich PA, Schnittger I, Strauss HW, et al. Screening for coronary artery disease after mediastinal irradiation for Hodgkin’s disease. J Clin Oncol. 2007;25(12):43–9.

    PubMed  Google Scholar 

  17. Lancellotti P, Nkomo VT, Badano LP, BerglerKlein J, Bogaert J, Davin L, et al. Expert consensus for multi-modality imaging evaluationof cardiovascular complications of radiotherapy in adults: a report from the European Association of Cardiovascular Imaging and the American Society of Echocardiography. J Am Soc Echocardiogr. 2013;26(9):1013–32.

    Article  PubMed  Google Scholar 

  18. Steele SR, Martin MJ, Mullenix PS, et al. Focused high-risk population screening for carotid arterial stenosis after radiation therapy for head and neck cancer. Am J Surg. 2004;187:594–8.

    Article  PubMed  Google Scholar 

  19. Darby SC, Ewertz M, McGale P, et al. Risk of ischemic heart disease in women after radiotherapy for breast cancer. N Engl J Med. 2013;368:987–98.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to S. Wamique Yusuf .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Yusuf, S.W. (2018). Radiation Related Cardiovascular Disease. In: Yusuf, S., Banchs, J. (eds) Cancer and Cardiovascular Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-62088-6_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-62088-6_7

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-62086-2

  • Online ISBN: 978-3-319-62088-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics