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The Cambridge Examination for Mental Disorders of Older People with Down’s Syndrome and Others with Intellectual Disabilities (CAMDEX-DS)

  • Luciana Mascarenhas Fonseca
  • Sarah L. Ball
  • Anthony J. HollandEmail author
Chapter

Abstract

The Cambridge Examination for Mental Disorders of Older People with Down’s Syndrome and Others with Intellectual Disabilities (CAMDEX-DS) is a diagnostic assessment schedule developed in response to an identified need for valid and reliable methods for the assessment and diagnosis of dementia in people with intellectual disability (ID). While the increased risk of dementia in people with Down syndrome (DS) in particular means that the schedule is especially valuable for use in this population, it can also been used when dementia is suspected in those with developmentally acquired ID for reasons other than that of DS. Accurate and consistent diagnosis is essential for both clinical practice and research and will be increasingly important as effective treatments for dementia become available.

Keywords

Cambridge Cognitive Examination Older People Intellectual Disabilities Mental Disorders Assessment Schedule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Aylward E, Burt D, Thorpe L, et al. Diagnosis of dementia in individuals with intellectual disability: report of the task force for development of criteria for diagnosis of dementia in individuals with mental retardation. J Intellect Disabil Res. 1997;41:152–64.CrossRefPubMedGoogle Scholar
  2. 2.
    American Psychiatric Association. Diagnostic and statistical manual of mental disorder. Washington: American Psychiatric Association; 2013.CrossRefGoogle Scholar
  3. 3.
    World Health Organisation. ICD-10 international statistical classification of diseases and related health problems. 10th ed. Geneva: WHO; 1992.Google Scholar
  4. 4.
    Roth M, Huppert FA, Mountjoy CQ, et al. CAMDEX-R: the cambridge examination for mental disorders of the elderly (revised). Cambridge: Cambridge University Press; 1998.Google Scholar
  5. 5.
    Roth M, Tym E, Mountjoy C, et al. CAMDEX—a standardised instrument for the diagnosis of mental disorder in the elderly with special reference to the early detection of dementia. Br J Psychiatry. 1986;149:698–709.CrossRefPubMedGoogle Scholar
  6. 6.
    Roth M, Huppert F, Tym E, et al. CAMDEX: the cambridge examination for mental disorder of the elderly. Cambridge: Cambridge University Press; 1988.Google Scholar
  7. 7.
    Neri M, Roth M, Vreese LPD, et al. The validity of informant reports in assessing the severity of dementia: evidence from the CAMDEX interview. Dementia Geriatr Cognit Disord. 1998;9:56–62.CrossRefGoogle Scholar
  8. 8.
    Huppert FA, Brayne C, Gill C, et al. CAMCOG—a concise neuropsychological test to assist dementia diagnosis: socio-demographic determinants in an elderly population sample. Br J Clin Psychol. 1995;34:529–41.CrossRefPubMedGoogle Scholar
  9. 9.
    Huppert FA, Jorm AF, Brayne C, et al. Psychometric properties of the CAMCOG and its efficacy in the diagnosis of dementia. Aging Neuropsychol Cogn. 1996;3:201–14.CrossRefGoogle Scholar
  10. 10.
    Williams JG, Huppert FA, Matthews FE, et al. Performance and normative values of a concise neuropsychological test (CAMCOG) in an elderly population sample. Int J Geriatr Psychiatry. 2003;18:631–44.CrossRefPubMedGoogle Scholar
  11. 11.
    Heinik J. Effects of trihexyphenidyl on MMSE and CAMCOG scores of medicated elderly patients with schizophrenia. Int Psychogeriatr. 1998;10:103–8.CrossRefPubMedGoogle Scholar
  12. 12.
    Jobst K, Smith A, Szatmari M, et al. Detection in life of confirmed Alzheimer’s disease using a simple measurement of medial temporal lobe atrophy by computed tomography. Lancet. 1992;340:1179–83.CrossRefPubMedGoogle Scholar
  13. 13.
    Mate KE, Kerr KP, Pond D, et al. Impact of multiple low-level anticholinergic medications on anticholinergic load of community-dwelling elderly with and without dementia. Drugs Aging. 2015;32:159–67.CrossRefPubMedGoogle Scholar
  14. 14.
    Clarke MCJ, Anderson J. The prevalence of dementia in a total population: A comparison of two screening instruments. Aging. 1991;20:396–403.Google Scholar
  15. 15.
    Cullum S, Huppert FA, McGee M, et al. Decline across different domains of cognitive function in normal ageing: results of a longitudinal population-based study using CAMCOG. Int J Geriatr Psychiatry. 2000;15:853–62.CrossRefPubMedGoogle Scholar
  16. 16.
    O’Connor D, Pollitt P, Hyde J, et al. The prevalence of dementia as measured by the Cambridge mental disorders of the elderly examination. Acta Psychol Scand. 1989;79:190–8.CrossRefGoogle Scholar
  17. 17.
    Schmand B, Walstra G, Lindeboom J, et al. Early detection of Alzheimer’s disease using the Cambridge cognitive examination (CAMCOG). Psychol Med. 2000;30:619–27.CrossRefPubMedGoogle Scholar
  18. 18.
    Heinik J, Solomesh I, Berkman P. Correlation between the CAMCOG, the MMSE, and three clock drawing tests in a specialized outpatient psychogeriatric service. Arch Gerontol Geriatr. 2004;38:77–84.CrossRefPubMedGoogle Scholar
  19. 19.
    Nielsen H, Lolk A, Andersen K, et al. Characteristics of elderly who develop Alzheimer’s disease during the next two years—a neuropsychological study using CAMCOG: the odense study. Int J Geriatr Psychiatry. 1999;14:957–63.CrossRefPubMedGoogle Scholar
  20. 20.
    Cecato JF, Fiorese B, Montiel JM, et al. Clock drawing test in elderly individuals with different education levels: correlations with clinical dementia rating. Am J Alzheimers Dis Other Demen. 2012;27:620–4.CrossRefPubMedGoogle Scholar
  21. 21.
    Forstl H, Burns A, Jacoby R, et al. Neuroanatomical correlates of clinical misidentification and misperception in senile dementia of the Alzheimer type. J Clin Psychopharmacol. 1991;52:268–71.Google Scholar
  22. 22.
    Gertz H, Xuereb J, Huppert F, et al. The relationship between clinical dementia and neuropathological staging (BRAAK) in a very elderly community sample. Eur Arch Psychiatry Clin Neurosci. 1996;246:132–6.CrossRefPubMedGoogle Scholar
  23. 23.
    Mak E, Su L, Williams GB, et al. Differential atrophy of hippocampal subfields: a comparative study of dementia with Lewy bodies and Alzheimer disease. Am J Geriatr Psychiatry. 2016;24:136–43.CrossRefPubMedGoogle Scholar
  24. 24.
    Cabranes J, De Juan R, Encinas M, et al. Relevance of functional neuroimaging in the progression of mild cognitive impairment. Neurol Res. 2004;26:496–501.CrossRefPubMedGoogle Scholar
  25. 25.
    Hunter R, McLuskie R, Wyper P, et al. The patterns of function-related cerebral blood flow investigated by single photon emission tomography with 99 m Tc-HMPAO in patients with presenile Alzheimer’s disease and Korsakoff’s psychosis. Psychol Med. 1989;19:847–55.CrossRefPubMedGoogle Scholar
  26. 26.
    Azevedo D, Tatsch M, Hototian SR, et al. Proton spectroscopy in Alzheimer’s disease and cognitive impairment no dementia: a community-based study. Dementia Geriatr Cognit Disord. 2008;25:491–500.CrossRefGoogle Scholar
  27. 27.
    Lawton MP, Brody EM. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist. 1969;9:179–86.CrossRefPubMedGoogle Scholar
  28. 28.
    Saxton J, McGonigle KL, Swihart AA, et al. The Severe impairment battery. Bury St. Edmunds: Thames Valley Test Company; 1993.Google Scholar
  29. 29.
    Witts P, Elders S. The ‘severe impairment battery’: assessing cognitive ability in adults with Down syndrome. Br J Clin Psychol. 1998;37:213–6.CrossRefPubMedGoogle Scholar
  30. 30.
    Ball SL, Holland AJ, Huppert FA, et al. The modified CAMDEX informant interview is a valid and reliable tool for use in the diagnosis of dementia in adults with Down’s syndrome. J Intellect Disabil Res. 2004;48:611–20.CrossRefPubMedGoogle Scholar
  31. 31.
    Deb S, Braganza J. Comparison of rating scales for the diagnosis of dementia in adults with Down’s syndrome. J Intellect Disabil Res. 1999;43:400–7.CrossRefPubMedGoogle Scholar
  32. 32.
    Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics. 1977;33:159–74.CrossRefPubMedGoogle Scholar
  33. 33.
    Hon J, Huppert FA, Holland AJ, et al. Neuropsychological assessment of older adults with Down’s syndrome: an epidemiological study using the Cambridge cognitive examination (CAMCOG). Br J Clin Psychol. 1999;38:155–65.CrossRefPubMedGoogle Scholar
  34. 34.
    Folstein M, Folstein S, McHugh P. Mini-Mental State. A practical method for grading the cognitive state of patients for the clinician. J Psychol Res. 1975;12:189–98.CrossRefGoogle Scholar
  35. 35.
    Hewitt KE, Carter G, Jancar J. Ageing in Down’s syndrome. Br J Psychiatry. 1985;147:58–62.CrossRefPubMedGoogle Scholar
  36. 36.
    Holland AJ, Hon J, Huppert FA, et al. Population-based study of the prevalence and presentation of dementia in adults with Down’s syndrome. Br J Psychiatry. 1998;172:493–8.CrossRefPubMedGoogle Scholar
  37. 37.
    Lai F, Williams RS. A prospective study of Alzheimer disease in Down syndrome. Arch Neurol. 1989;46:849–53.CrossRefPubMedGoogle Scholar
  38. 38.
    Wisniewski KE, Wisniewski HM, Wen GY. Occurrence of neuropathological changes and dementia of Alzheimer’s disease in Down’s syndrome. Ann Neurol. 1985;17:278–82.CrossRefPubMedGoogle Scholar
  39. 39.
    Gregory CA, Hodges JR. Dementia of frontal type and the focal lobar atrophies. Int Rev Psychiatry. 1993;5:397–406.CrossRefGoogle Scholar
  40. 40.
    Holland AJ, Hon J, Huppert FA, et al. Incidence and course of dementia in people with Down’s syndrome: findings from a population-based study. J Intellect Disabil Res. 2000;44:138–46.CrossRefPubMedGoogle Scholar
  41. 41.
    Crome L, Stern L. Pathology of mental retardation. Baltimore, MD: Williams and Wilkins; 1972.Google Scholar
  42. 42.
    Ball SL, Holland AJ, Hon J, et al. Personality and behaviour changes mark the early stages of Alzheimer’s disease in adults with Down’s syndrome: findings from a prospective population-based study. Int J Geriatr Psychiatry. 2006;21:661–73.CrossRefPubMedGoogle Scholar
  43. 43.
    Royall DR, Cordes JA, Polk M. CLOX: an executive clock drawing task. J Neurol Neurosurg Psychiatry. 1998;64:588–94.CrossRefPubMedPubMedCentralGoogle Scholar
  44. 44.
    Prasher VP, Farooq A, Holder R. The adaptive behaviour dementia questionnaire (ABDQ): screening questionnaire for dementia in Alzheimer’s disease in adults with Down syndrome. Res Dev Disabil. 2004;25:385–97.CrossRefPubMedGoogle Scholar
  45. 45.
    Prasher VP, Barber PC, West R, et al. The role of magnetic resonance imaging in the diagnosis of Alzheimer disease in adults with Down syndrome. Arch Neurol. 1996;53:1310–3.CrossRefPubMedGoogle Scholar
  46. 46.
    Rubinsztein DC, Hon J, Stevens F, et al. Apo E genotypes and risk of dementia in Down syndrome. Am J Med Genet B Neuropsychiatr Genet. 1999;88:344–7.CrossRefGoogle Scholar
  47. 47.
    Ball SL, Holland AJ, Watson PC, et al. Theoretical exploration of the neural bases of behavioural disinhibition, apathy and executive dysfunction in preclinical Alzheimer’s disease in people with Down’s syndrome: potential involvement of multiple frontal-subcortical neuronal circuits. J Intellect Disabil Res. 2010;54:320–36.CrossRefPubMedGoogle Scholar
  48. 48.
    Landt J, Ball SL, Holland AJ, et al. Age-related changes in plasma dehydroepiandrosterone levels in adults with Down’s Syndrome and the risk of dementia. J Neuroendocrinol. 2011;23:450–5.CrossRefPubMedGoogle Scholar
  49. 49.
    Annus T, Wilson LR, Hong YT, et al. The pattern of amyloid accumulation in the brains of adults with Down syndrome. Alzheimers Dement. 2016;12:538–45.CrossRefPubMedPubMedCentralGoogle Scholar
  50. 50.
    Beacher F, Simmons A, Daly E, et al. Hippocampal myo-inositol and cognitive ability in adults with Down syndrome: an in vivo proton magnetic resonance spectroscopy study. Arch Gen Psychiatry. 2005;62:1360–5.CrossRefPubMedGoogle Scholar
  51. 51.
    Hassiotis A, Strydom A, Allen K, et al. A memory clinic for older people with intellectual disabilities. Aging Ment Health. 2003;7:418–23.CrossRefPubMedGoogle Scholar
  52. 52.
    Oliver C, Crayton L, Holland A, et al. A four year prospective study of age-related cognitive change in adults with Down’s syndrome. Psychol Med. 1998;28:1365–77.CrossRefPubMedGoogle Scholar
  53. 53.
    Fonseca LM, Oliveira MC, Guilhoto LMFF, et al. Bereavement and behavioral changes as risk factors for cognitive decline in adults with Down syndrome. Neuropsychiatr Dis Treat. 2014;10:2209–19.CrossRefPubMedPubMedCentralGoogle Scholar
  54. 54.
    McPaul A, Walker B, Law J et al. (2016) An exploratory study investigating how adults with intellectual disabilities perform on the visual association test (VAT). J Appl Res Intellect Disabil (Epub ahead of print)Google Scholar
  55. 55.
    Esteba-Castillo S, Dalmau-Bueno A, Ribas-Vidal N, et al. Adaptation and validation of CAMDEX-DS (Cambridge examination for mental disorders of older people with Down’s syndrome and others with intellectual disabilities) in Spanish population with intellectual disabilities. Rev Neurol. 2013;57:337–46.PubMedGoogle Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Luciana Mascarenhas Fonseca
    • 1
  • Sarah L. Ball
    • 2
  • Anthony J. Holland
    • 2
    Email author
  1. 1.Instituto de Psiquiatria do Hospital das Clínicas da Universidade de São PauloSão PauloBrazil
  2. 2.Department of PsychiatryUniversity of CambridgeCambridgeUK

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