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Evolutionary Biology: Self/Nonself Evolution, Species and Complex Traits Evolution, Methods and Concepts pp 63–85Cite as

How the Other Half Lives: CRISPR-Cas’s Influence on Bacteriophages

Abstract

CRISPR-Cas is a genetic adaptive immune system unique to prokaryotic cells used to combat phage and plasmid threats. The host cell adapts by incorporating DNA sequences from invading phages or plasmids into its CRISPR locus as spacers. These spacers are expressed as mobile surveillance RNAs that direct CRISPR-associated (Cas) proteins to protect against subsequent attack by the same phages or plasmids. The threat from mobile genetic elements inevitably shapes the CRISPR loci of archaea and bacteria, and simultaneously the CRISPR-Cas immune system drives evolution of these invaders. Here, we highlight our recent work, as well as that of others, that seeks to understand phage mechanisms of CRISPR-Cas evasion and conditions for population coexistence of phages with CRISPR-protected prokaryotes.

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Acknowledgements

This work was partially supported by the Center for Theoretical Biological Physics at Rice University, Houston, TX 77005, USA.

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Authors and Affiliations

  1. Department of Physics and Astronomy, Rice University, Houston, TX, 77005, USA

    Melia E. Bonomo & Michael W. Deem

  2. Department of Bioengineering, Rice University, Houston, TX, 77005, USA

    Michael W. Deem

  3. Center for Theoretical Biological Physics, Rice University, Houston, TX, 77005, USA

    Melia E. Bonomo & Michael W. Deem

Authors
  1. Melia E. Bonomo
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  2. Michael W. Deem
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Correspondence to Michael W. Deem .

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Editors and Affiliations

  1. Laboratoire Evolution Biologique et Modélisation, CNRS, Université d’Aix-Marseille, Marseille, France

    Dr. Pierre Pontarotti

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Bonomo, M.E., Deem, M.W. (2017). How the Other Half Lives: CRISPR-Cas’s Influence on Bacteriophages. In: Pontarotti, P. (eds) Evolutionary Biology: Self/Nonself Evolution, Species and Complex Traits Evolution, Methods and Concepts. Springer, Cham. https://doi.org/10.1007/978-3-319-61569-1_4

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