Immune deficiency is the third most commonly identified cause for bronchiectasis, after cystic fibrosis and postinfectious bronchiectasis, in children and adults. In this chapter we describe primary and secondary immune deficiencies that are commonly complicated by bronchiectasis including specific investigations required to make these diagnoses. We focus on antibody deficiency which is the most common immune deficiency identified in bronchiectasis. Key investigations that should be performed on all idiopathic bronchiectatic patients are outlined. Finally, we describe the management of bronchiectasis in immune-deficient patients including recommendations on immunisation, antibiotic prophylaxis, immunoglobulin replacement therapy, joint respiratory-immunology care clinics and long-term monitoring.
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Coulter, T.I., Devlin, L., Downey, D., Elborn, J.S., Edgar, J.D.M. (2018). Immunodeficiency in Bronchiectasis. In: Chalmers, J., Polverino, E., Aliberti, S. (eds) Bronchiectasis. Springer, Cham. https://doi.org/10.1007/978-3-319-61452-6_7
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