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Fatty Liver Disease

  • Scott C. Beeman
  • Joel R. GarbowEmail author
Chapter

Abstract

Fatty liver disease is a debilitating, expensive, and potentially fatal pathology of rapidly increasing incidence. Currently, detection, characterization, and diagnosis of fatty liver disease rely heavily on blood serum biomarkers and biopsy—methods which are either nonspecific to fatty liver disease (serum biomarkers) or invasive and highly focal (biopsy). In this chapter, we detail state-of-the-art imaging techniques for detecting and quantifying fatty liver disease, its precursors, and its downstream complications. Methods for detecting fatty liver with ultrasound (US) and computed tomography (CT) are discussed first. Special emphasis is then placed on magnetic resonance (MR)-based techniques, which are inherently sensitive to the molecular composition of tissue and can quantify the so-called proton density fat fraction of the liver with extremely high accuracy and precision. Finally, preclinical and investigational techniques, including novel US, CT, and MR methods, as well as positron emission tomography and optical imaging techniques, are discussed.

Keywords

Hepatorenal contrast Liver-spleen ratio Magnetic resonance spectroscopy Dixon method Signal fat fraction Proton density fat fraction 

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Mallinckrodt Institute of RadiologyWashington UniversitySt. LouisUSA
  2. 2.The Alvin J. Siteman Cancer CenterWashington UniversitySt. LouisUSA

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