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Stimulated Microgravity and Induction of Angiogenesis; A New Perspective in Wound Healing

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Biochemical Basis and Therapeutic Implications of Angiogenesis

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 6))

Abstract

The current research interest in the therapeutic management of wound healing is to attain a complete and rapid healing of chronic wounds with minimal scar. There is an urge to apply a novel approach to prompt the wound healing process because of the huge economic burden worldwide. Hence, the current article initially focuses on the management and care of wounds from classic to currently available techniques and vulnerability of wound. Several propositions for better wound healing has been proposed, one of them is simulated microgravity which heals the wounds by promoting microgravity. Stimulated microgravity induces changes in cytoskeleton; thereby it regulates the behavior of endothelial cells in terms of cell proliferation, adhesion, migration, production of extracellular matrix and translocation of bioactive molecules inside the cells. Additionally, we have listed around 40 genes which are potentially involved in angiogenesis and are differentially expressed in endothelial cells under microgravity conditions. The coordinated cellular and molecular events in endothelial cells in microgravity promote angiogenesis which in turn facilitates wound healing process.

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Acknowledgement

This work was supported by research grant from Department of Science and Technology, Science and Engineering Research Board (SERB), India to S. Vimalraj (grant no. PDF/2015/000133). This work was partially supported by a grant from the University Grant Commission-Faculty Research Program (UGC-FRP), Government of India to SC.

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Authors and Affiliations

  1. Vascular Biology Lab, AU-KBC Research Centre, MIT Campus of Anna University, Chromepet, Chennai, 600044, India

    Selvaraj Vimalraj Ph.D, Kasiviswanathan Dharanibalan & Suvro Chatterjee Ph.D

  2. Department of Biotechnology, Anna University, Chennai, India

    Suvro Chatterjee Ph.D

Authors
  1. Selvaraj Vimalraj Ph.D
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  2. Kasiviswanathan Dharanibalan
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  3. Suvro Chatterjee Ph.D
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Correspondence to Suvro Chatterjee Ph.D .

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Editors and Affiliations

  1. Divison of Cardiovascular Medicine, University of Arkansas for Medical Sciences, Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, USA

    Jawahar L. Mehta

  2. Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

    Pankaj Mathur

  3. Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Department of Physiology and Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada

    Naranjan S. Dhalla

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Vimalraj, S., Dharanibalan, K., Chatterjee, S. (2017). Stimulated Microgravity and Induction of Angiogenesis; A New Perspective in Wound Healing. In: Mehta, J., Mathur, P., Dhalla, N. (eds) Biochemical Basis and Therapeutic Implications of Angiogenesis. Advances in Biochemistry in Health and Disease, vol 6. Springer, Cham. https://doi.org/10.1007/978-3-319-61115-0_22

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