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Angiogenesis and Atherosclerosis

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Biochemical Basis and Therapeutic Implications of Angiogenesis

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 6))

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Abstract

Atherosclerotic heart disease is the leading cause of morbidity and mortality worldwide. Despite recent advances in our understanding of atherosclerosis the role of angiogenesis in atherosclerosis is still being debated. The use of therapeutic angiogenesis has been widely regarded as an attractive approach in treatment of ischemic heart disease. On the other hand, there is growing evidence that neovascularization contributes to the progression of atherosclerotic lesions, and that it may play key role in intraplaque hemorrhage, plaque destabilization and rupture. Most trials on therapeutic angiogenesis using growth factors like VEGF (vascular endothelial growth factor)/FGF (fibroblast growth factor) have used single agents and are inconclusive. Bench and bedside research continues to bring insight into new mechanisms of atherosclerosis and tumor growth. Further understanding of different facets of angiogenesis may help in the development of novel and specific therapies.

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Authors and Affiliations

  1. Department of Medicine, University of Arkansas Medical Sciences, Little Rock, AR, USA

    Pankaj Mathur MD & Ajoe John Khattoor MD

  2. Division of Cardiovascular Medicine, University of Louisville, Louisville, KY, USA

    Sadip Pant MD

  3. Heart Rhythm Section, Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA

    Abhishek Deshmukh MD

  4. Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences, Central Arkansas Veterans Healthcare System, Little Rock, AR, USA

    Jawahar L. Mehta MD, PhD

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  1. Pankaj Mathur MD
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  2. Sadip Pant MD
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  3. Abhishek Deshmukh MD
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  4. Ajoe John Khattoor MD
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  5. Jawahar L. Mehta MD, PhD
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Correspondence to Jawahar L. Mehta MD, PhD .

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Editors and Affiliations

  1. Divison of Cardiovascular Medicine, University of Arkansas for Medical Sciences, Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, USA

    Jawahar L. Mehta

  2. Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

    Pankaj Mathur

  3. Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Department of Physiology and Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada

    Naranjan S. Dhalla

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Mathur, P., Pant, S., Deshmukh, A., Khattoor, A.J., Mehta, J.L. (2017). Angiogenesis and Atherosclerosis. In: Mehta, J., Mathur, P., Dhalla, N. (eds) Biochemical Basis and Therapeutic Implications of Angiogenesis. Advances in Biochemistry in Health and Disease, vol 6. Springer, Cham. https://doi.org/10.1007/978-3-319-61115-0_16

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