This chapter analyzes in detail the applications that can support the digital transformation of agile procurement. It starts out by analyzing “classical” ICT solutions, such as the ERP and its main components, which can help procurement mainly from an administrative and accounting point of view. Next it analyzes in detail e-procurement and its components, which can help in both operational activities and interfaces with vendors. The chapter considers the barriers and the benefits of e-procurement and the challenges in its implementation. The approach is based on an innovative architecture that allows for analysis of the components already available and the ones that are not yet available.