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Malignant Inguinal Adenopathy: Considerations for the Radiation Oncologist

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Malignancies of the Groin

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Abstract

Primary malignancies involving structures of the lower pelvis and perineum, including the vulva, penis, and anal canal, frequently spread to the groin. For each of these malignancies, radiotherapy (RT) may play a role in definitive management, adjuvant treatment, or palliation. This has important implications in clinical decision-making for the radiation oncologist who must appreciate the prognostic factors affecting the risk of metastases, the indications for treating the inguinal region, the associated considerations in planning treatment, and the acute and late effects of treatment.

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Abbreviations

3D-CRT:

3D conformal radiotherapy

AP:

Anterior-posterior

AP-PA:

Parallel-opposed anteroposterior

Chemo-RT:

Combined modality treatment

CR:

Complete response

CT:

Computed tomography

CTCAE:

Common terminology criteria for adverse events

CTV:

Clinical target volume

EORTC:

European Organization for Research and Treatment of Cancer

FDG-PET:

Fluorodeoxyglucose-positron emission tomography

GTV:

Gross tumor volume

GOG:

Gynecologic Oncology Group

GOG 88:

Gynecologic Oncology Group protocol 88 trial

ILND:

Inguinal lymph node dissection

IMRT:

Intensity-modulated radiotherapy

InPACT:

International Penile Advanced Cancer Trial (NCT 02305654)

LVI:

Lymphovascular invasion

MRI:

Magnetic resonance imaging

NCCN:

National Comprehensive Cancer Network

PA:

Posterior-anterior

PET-CT:

Positron emission tomography–computed tomography

PLND:

Pelvic lymph node dissection

PTV:

Planning target volume

RT:

Radiotherapy

RTOG:

Radiation Therapy Oncology Group

SCC:

Squamous cell carcinoma

SLNB:

Sentinel lymph node biopsy

TROG:

Trans Tasman Radiation Oncology Group

UKCCCR:

UK Coordinating Committee on Cancer Research

VMAT:

Volumetric arc therapy

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Authors and Affiliations

  1. Division of Radiotherapy and Developmental Radiotherapeutics, Department of Radiation Oncology, University of British Columbia, BC Cancer Agency, 399 Royal Avenue, Kelowna, V1Y5L3, British Columbia, Canada

    Martin Korzeniowski M.D., F.R.C.P.C. & Juanita Crook M.D., F.R.C.P.C.

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  1. Martin Korzeniowski M.D., F.R.C.P.C.
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  2. Juanita Crook M.D., F.R.C.P.C.
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Correspondence to Juanita Crook M.D., F.R.C.P.C. .

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Editors and Affiliations

  1. Division of Surgical Oncology, Department of Surgery, Emory University School of Medicine, Atlanta, Georgia, USA

    Keith A. Delman

  2. Department of Urology, Emory University School of Medicine, Atlanta, Georgia, USA

    Viraj A. Master

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Korzeniowski, M., Crook, J. (2018). Malignant Inguinal Adenopathy: Considerations for the Radiation Oncologist. In: Delman, K., Master, V. (eds) Malignancies of the Groin. Springer, Cham. https://doi.org/10.1007/978-3-319-60858-7_11

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