Skip to main content

The Patient with End-Stage Renal Disease

  • Chapter
  • First Online:
Book cover Anesthesia in High-Risk Patients

Abstract

Patients suffering from end-stage renal disease (ESRD) are at high risk of surgery and perioperative complications. The renal disease has a global impact on the organism and creates significant disturbances to the metabolism, especially electrolyte disorders, excessive bleeding, fluid overload, heart failure and drug toxicity. Patients with ESRD may also have a remaining kidney function, which must be preserved during the perioperative period. The management of ESRD patients is based on three important steps. Firstly, evaluate the level of renal disease and its impact on patient conditions and comorbidities. Secondly, choose appropriate drugs and dosage while avoiding new renal insults that may impair the remaining kidney function or create metabolic disorders. Lastly, take care of fluid’s volume variations and electrolytes disturbances for each patient during all the perioperative time.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Stevens PE, Levin A, Kidney Disease: Improving Global Outcomes Chronic Kidney Disease Guideline Development Work Group Members. Evaluation and management of chronic kidney disease: synopsis of the kidney disease: improving global outcomes 2012 clinical practice guideline. Ann Intern Med. 2013;158:825–30.

    Article  PubMed  Google Scholar 

  2. Saran R, Li Y, Robinson B, Abbott KC, Agodoa LYC, Ayanian J, et al. US Renal Data System 2015 Annual Data Report: epidemiology of kidney disease in the United States. Am J Kidney Dis. 2016;67(3 Suppl 1):Svii–S1–305.

    Google Scholar 

  3. Cooper WA, O’Brien SM, Thourani VH, Guyton RA, Bridges CR, Szczech LA, et al. Impact of renal dysfunction on outcomes of coronary artery bypass surgery: results from the Society of Thoracic Surgeons National Adult Cardiac Database. Circulation. 2006;113(8):1063–70.

    Article  PubMed  Google Scholar 

  4. Holzmann M, Jernberg T, Szummer K, Sartipy U. Long-term cardiovascular outcomes in patients with chronic kidney disease undergoing coronary artery bypass graft surgery for acute coronary syndromes. J Am Heart Assoc. 2014;3(2):e000707–7.

    Google Scholar 

  5. Minakata K, Bando K, Tanaka S, Takanashi S, Konishi H, Miyamoto Y, et al. Preoperative chronic kidney disease as a strong predictor of postoperative infection and mortality after coronary artery bypass grafting. Circ J. 2014;78(9):2225–31.

    Article  PubMed  Google Scholar 

  6. Lautamäki A, Kiviniemi T, Biancari F, Airaksinen J, Juvonen T, Gunn J. Outcome after coronary artery bypass grafting and percutaneous coronary intervention in patients with stage 3b-5 chronic kidney disease. Eur J Cardiothorac Surg. 2016;49(3):926–30.

    Article  PubMed  Google Scholar 

  7. Pinson CW, Schuman ES, Gross GF, Schuman TA, Hayes JF. Surgery in long-term dialysis patients. Experience with more than 300 cases. Am J Surg. 1986;151(5):567–71.

    Article  CAS  PubMed  Google Scholar 

  8. Winkelmayer WC, Levin R, Avorn J. Chronic kidney disease as a risk factor for bleeding complications after coronary artery bypass surgery. Am J Kidney Dis. 2003;41(1):84–9.

    Article  PubMed  Google Scholar 

  9. Kasiske BL, Maclean JR, Snyder JJ. Acute myocardial infarction and kidney transplantation. J Am Soc Nephrol. 2006;17(3):900–7.

    Article  PubMed  Google Scholar 

  10. McClellan WM, Chertow GM. Beyond Framingham: cardiovascular risk profiling in ESRD. J Am Soc Nephrol. 2005;16(6):1539–41.

    Article  PubMed  Google Scholar 

  11. Charra B, Calemard M, Laurent G. Importance of treatment time and blood pressure control in achieving long-term survival on dialysis. Am J Nephrol. 1996;16(1):35–44.

    Article  CAS  PubMed  Google Scholar 

  12. Foley RN, Parfrey PS, Harnett JD, Kent GM, Murray DC, Barre PE. Impact of hypertension on cardiomyopathy, morbidity and mortality in end-stage renal disease. Kidney Int. 1996;49(5):1379–85.

    Article  CAS  PubMed  Google Scholar 

  13. Guarracino F, Baldassarri R, Priebe HJ. Revised ESC/ESA Guidelines on non-cardiac surgery: cardiovascular assessment and management. Implications for preoperative clinical evaluation. Minerva Anestesiol. 2015;81(2):226–33.

    CAS  PubMed  Google Scholar 

  14. Kramer A, Pippias M, Stel VS, Bonthuis M, Abad Diez JM, Afentakis N, et al. Renal replacement therapy in Europe: a summary of the 2013 ERA-EDTA Registry Annual Report with a focus on diabetes mellitus. Clin Kidney J. 2016;9(3):457–69.

    Article  PubMed  PubMed Central  Google Scholar 

  15. London GM, De Vernejoul MC, Fabiani F, Marchais SJ, Guerin AP, Metivier F, et al. Secondary hyperparathyroidism and cardiac hypertrophy in hemodialysis patients. Kidney Int. 1987;32(6):900–7.

    Article  CAS  PubMed  Google Scholar 

  16. de Mutsert R, Grootendorst DC, Axelsson J, Boeschoten EW, Krediet RT, Dekker FW, et al. Excess mortality due to interaction between protein-energy wasting, inflammation and cardiovascular disease in chronic dialysis patients. Nephrol Dial Transplant. 2008;23(9):2957–64.

    Article  PubMed  Google Scholar 

  17. Harnett JD, Kent GM, Foley RN, Parfrey PS. Cardiac function and hematocrit level. Am J Kidney Dis. 1995;25(4 Suppl 1):S3–7.

    Article  CAS  PubMed  Google Scholar 

  18. Abstract. Kidney Int Suppl (2011). 2012;2(4):282.

    Google Scholar 

  19. Ickx B, Cockshott ID, Barvais L, Byttebier G, De Pauw L, Vandesteene A, et al. Propofol infusion for induction and maintenance of anaesthesia in patients with end-stage renal disease. Br J Anaesth. 1998;81(6):854–60.

    Article  CAS  PubMed  Google Scholar 

  20. Shafer SL. Shock values. Anesthesiology. 2004;101(3):567–8.

    Article  PubMed  Google Scholar 

  21. Thapa S, Brull SJ. Succinylcholine-induced hyperkalemia in patients with renal failure: an old question revisited. Anesth Analg. 2000;91(1):237–41.

    CAS  PubMed  Google Scholar 

  22. Cooper RA, Maddineni VR, Mirakhur RK, Wierda JM, Brady M, Fitzpatrick KT. Time course of neuromuscular effects and pharmacokinetics of rocuronium bromide (Org 9426) during isoflurane anaesthesia in patients with and without renal failure. Br J Anaesth. 1993;71(2):222–6.

    Article  CAS  PubMed  Google Scholar 

  23. Sparr HJ, Beaufort TM, Fuchs-Buder T. Newer neuromuscular blocking agents: how do they compare with established agents? Drugs. 2001;61(7):919–42.

    Article  CAS  PubMed  Google Scholar 

  24. Rocca Della G, Pompei L, Coccia C, Costa MG, Cecchini V, Vilardi V, et al. Atracurium, cisatracurium, vecuronium and rocuronium in patients with renal failure. Minerva Anestesiol. 2003;69(7-8):605. –11–612–5

    Google Scholar 

  25. Goldberg ME, Cantillo J, Larijani GE, Torjman M, Vekeman D, Schieren H. Sevoflurane versus isoflurane for maintenance of anesthesia: are serum inorganic fluoride ion concentrations of concern? Anesth Analg. 1996;82(6):1268–72.

    CAS  PubMed  Google Scholar 

  26. Conzen PF, Kharasch ED, Czerner SFA, Artru AA, Reichle FM, Michalowski P, et al. Low-flow sevoflurane compared with low-flow isoflurane anesthesia in patients with stable renal insufficiency. Anesthesiology. 2002;97(3):578–84.

    Article  CAS  PubMed  Google Scholar 

  27. Gentz BA, Malan TP. Renal toxicity with sevoflurane: a storm in a teacup? Drugs. 2001;61(15):2155–62.

    Article  CAS  PubMed  Google Scholar 

  28. Liu LL, Gropper MA. Postoperative analgesia and sedation in the adult intensive care unit: a guide to drug selection. Drugs. 2003;63:755–67.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Olivier Joannès-Boyau .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG

About this chapter

Cite this chapter

Dewitte, A., Joannès-Boyau, O. (2018). The Patient with End-Stage Renal Disease. In: Fellahi, JL., Leone, M. (eds) Anesthesia in High-Risk Patients. Springer, Cham. https://doi.org/10.1007/978-3-319-60804-4_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-60804-4_10

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-60803-7

  • Online ISBN: 978-3-319-60804-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics