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Tissue Organoids: Liver

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Tumor Organoids

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

The development of novel and consistent biologic surrogates for drug discovery, toxicology, and cancer research is presently intense and involves a growing number of research groups and institutions around the world. The Twilight of the days of immortalized cell lines as the workhorse of most of our drug development and cancer research efforts seem now to be heading to their end with the introduction of body-on-a-chip platforms, bioengineered tissues and stem cell organoids. In this chapter, we describe the fundamental work and the different strategies that lead to some of the breakthroughs in the generation of hepatic tissue ex vivo. Lastly, we define its increasing use and applications by pharmaceutical industry and research laboratories.

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Authors and Affiliations

  1. Digestive Pathology Research Group, Instituto de Investigación Sanitaria de Aragón (IIS Aragón), Zaragoza, Spain

    Estela Solanas, Iris Pla-Palacín, Pilar Sainz-Arnal, Manuel Almeida, Alberto Lue, Trinidad Serrano & Pedro M. Baptista

  2. Instituto Aragonés de Ciencias de la Salud (IACS), Zaragoza, Spain

    Pilar Sainz-Arnal

  3. Gastroenterology Department, University Hospital Lozano Blesa, Zaragoza, Spain

    Alberto Lue & Trinidad Serrano

  4. Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz, Madrid, Spain

    Trinidad Serrano & Pedro M. Baptista

  5. CIBERehd, Madrid, Spain

    Trinidad Serrano & Pedro M. Baptista

  6. Departamento de Bioingeniería, Universidad Carlos III de Madrid, Madrid, Spain

    Pedro M. Baptista

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  1. Estela Solanas
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  2. Iris Pla-Palacín
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  3. Pilar Sainz-Arnal
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  4. Manuel Almeida
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  6. Trinidad Serrano
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  7. Pedro M. Baptista
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Correspondence to Pedro M. Baptista .

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Editors and Affiliations

  1. Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA

    Shay Soker

  2. Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA

    Aleksander Skardal

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Solanas, E. et al. (2018). Tissue Organoids: Liver. In: Soker, S., Skardal, A. (eds) Tumor Organoids. Cancer Drug Discovery and Development. Humana Press, Cham. https://doi.org/10.1007/978-3-319-60511-1_2

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