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Management of Hepatobiliary and Pancreatic Malignancies

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Book cover PET/CT in Hepatobiliary and Pancreatic Malignancies

Part of the book series: Clinicians’ Guides to Radionuclide Hybrid Imaging ((PET/CT))

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Abstract

Surgery plays an integral role and perhaps offers the only curative option in the management of hepatobiliary and pancreatic malignancies. Chemotherapy and radiation, either in the neoadjuvant or adjuvant setting, have further complemented the outcomes of radical surgery and play an important role in palliation. This chapter presents the principles of management of hepatocellular carcinoma (HCC), cancers of the gall bladder and biliary tract and pancreatic cancer.

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References

  1. Bruix J. Treatment of hepatocellular carcinoma. Hepatology. 1997;25:259.

    Article  CAS  PubMed  Google Scholar 

  2. Vauthey JN, Klimstra D, Franceschi D, et al. Factors affecting long-term outcome after hepatic resection for hepatocellular carcinoma. Am J Surg. 1995;169:28.

    Article  CAS  PubMed  Google Scholar 

  3. Bruix J, Castells A, Bosch J, et al. Surgical resection of hepatocellular carcinoma in cirrhotic patients: prognostic value of preoperative portal pressure. Gastroenterology. 1996;111:1018.

    Article  CAS  PubMed  Google Scholar 

  4. Roayaie S, Obeidat K, Sposito C, et al. Resection of hepatocellular cancer ≤2cm: results from two western centers. Hepatology. 2013;57:1426.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Mazzaferro V, Regalia E, Doci R, et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patient with cirrhosis. N Engl J Med. 1996;334:693.

    Article  CAS  PubMed  Google Scholar 

  6. Lo CN, Ngan H, Tsa WK, et al. Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma. Hepatology. 2002;35:1164.

    Article  CAS  PubMed  Google Scholar 

  7. Llovet JM, Real MI, Montana X, et al. Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomized controlled trial. Lancet. 2002;359:1734.

    Article  PubMed  Google Scholar 

  8. Salem R, Lewandowski RJ, Mulcahy MF, et al. Radioembolisation for hepatocellular carcinoma using yttrium-90 microspheres: a comprehensive report of long-term outcomes. Gastroenterology. 2010;138:52.

    Article  CAS  PubMed  Google Scholar 

  9. Llovet JM, Ricci S, Mazzaferro V, et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med. 2008;359:378–90.

    Article  CAS  PubMed  Google Scholar 

  10. Cheng AL, Kang YK, Chen Z, et al. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol. 2009;10:25–34.

    Article  CAS  Google Scholar 

  11. Jayaraman S, Jarnagin WR. Management of gall bladder cancer. Gastroenterol Clin North Am. 2010;39:331.

    Article  PubMed  Google Scholar 

  12. Shirai Y, Yoshida K, Tsukada K, et al. Early carcinoma of the gall bladder. Eur J Surg. 1992;158:545.

    CAS  PubMed  Google Scholar 

  13. Wakai T, Shirai Y, Yokoyama N, et al. Early gall bladder carcinoma does not warrant radical resection. Br J Surg. 2001;88:675.

    Article  CAS  PubMed  Google Scholar 

  14. You DD, Lee HG, Paik Ky, et al. What is an adequate extent of resection for T1 gall bladder cancers? Ann Surg 2008;247:835.

    Google Scholar 

  15. Matsumoto Y, Fujii H, Aoyama H, et al. Surgical treatment of primary carcinoma of the gall bladder based on the histologic analysis of 48 surgical specimens. Am J Surg. 1992;163:239.

    Article  CAS  PubMed  Google Scholar 

  16. Shimada H, Endo I, Togo S, et al. The role of lymph node dissection in the treatment of gall bladder carcinoma. Cancer. 1997;79:892.

    Article  CAS  PubMed  Google Scholar 

  17. Nimura Y, Hayakawa N, Kamiya J, et al. Hepatopancreatoduodenectomy for advanced carcinoma of the biliary tract. Hepatogastroenterology. 1991;38:170.

    CAS  PubMed  Google Scholar 

  18. Nakamura S, Suzuki S, Konno H, et al. Outcome of extensive surgery for TNM stage IV carcinoma of the gall bladder. Hepatogastroenterology. 1999;46:2138.

    CAS  PubMed  Google Scholar 

  19. Nakeeb A, Pitt HA, Sohn TA, et al. Cholangiocarcinoma. A spectrum of intrahepatic, perihilar and distal tumours. Ann Surg. 1996;224:463.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Lim JH, Choi GH, Choi SH, et al. Liver resection for Bismuth type I and type II hilar cholangiocarcinoma. World J Surg. 2013;37:829.

    Article  PubMed  Google Scholar 

  21. Tan JW, Hu BS, Chu YJ et al. one-stage resection for Bismuth type IV hilar cholangiocarcinoma with high hilar resection and parenchyma-preserving strategies: a cohort study. World J Surg 2013;37:614.

    Google Scholar 

  22. Hemming AW, Mekeel K, Khanna A, et al. Portal vein resection in management of hilar cholangiocarcinoma. J Am Coll Surg. 2011;212:604.

    Article  PubMed  Google Scholar 

  23. Ben-Josef E, Guthrie KA, El-Khoueiry AB, et al. SWOG S0890: a phase II intergroup trial of adjuvant capecitabine and gemcitabine followed by radiotherapy and concurrent capecitabine in extrahepatic cholangiocarcinoma and gall bladder carcinoma. J Clin Oncol. 2015;33:2617.

    Article  CAS  PubMed  Google Scholar 

  24. Diener MK, Knaebel HP, Heukaufer C, et al. A systematic review and meta-analysis of pylorus-preserving versus classical pancreaticoduodenectomy for surgical treatment of periampullary and pancreatic carcinoma. Ann Surg. 2007;245:187.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Van de Gaag NA, Rauws EA, van Eijck CH, et al. Preoperative biliary drainage for cancer of the head of pancreas. N Engl J Med. 2010;362:129.

    Article  Google Scholar 

  26. Barugola G, Partelli S, Crippa S, et al. Outcomes after resection of locally advanced or borderline resectable pancreatic cancer after neoadjuvant therapy. Am J Surg. 2012;203:132.

    Article  PubMed  Google Scholar 

  27. McClaine RJ, lowry AM, Sussman JJ, et al. Neoadjuvant therapy may lead to successful surgical resection and improved survival in patients with borderline resectable pancreatic cancer. HPB (Oxford) 2010;12:73.

    Google Scholar 

  28. Seufferlein T, Bachet JB, Van Cutsem E, et al. Pancreatic adenocarcinoma: ESMO-ESDO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2012;23(Suppl 7):vii33.

    Article  PubMed  Google Scholar 

  29. Khorana AA, Mangu PB, Berlin J, et al. Potentially curable pancreatic cancer: American society of clinical oncology clinical practice guidelines. J Clin Oncol. 2016;34:2541.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Gastrointestinal and HPB Surgery, Tata Memorial Centre, Mumbai, Maharashtra, India

    Ashwin deSouza M.S., M.Ch., M.R.C.S.Ed., D.N.B

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  1. Ashwin deSouza M.S., M.Ch., M.R.C.S.Ed., D.N.B
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Correspondence to Ashwin deSouza M.S., M.Ch., M.R.C.S.Ed., D.N.B .

Editor information

Editors and Affiliations

  1. Department of Nuclear Medicine and Molecular Imaging, Tata Memorial Hospital, Mumbai, Maharashtra, India

    Nilendu Purandare

  2. Department of Nuclear Medicine and Molecular Imaging, Tata Memorial Hospital, Mumbai, Maharashtra, India

    Sneha Shah

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deSouza, A. (2018). Management of Hepatobiliary and Pancreatic Malignancies. In: Purandare, N., Shah, S. (eds) PET/CT in Hepatobiliary and Pancreatic Malignancies. Clinicians’ Guides to Radionuclide Hybrid Imaging(). Springer, Cham. https://doi.org/10.1007/978-3-319-60507-4_3

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  • DOI: https://doi.org/10.1007/978-3-319-60507-4_3

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-60506-7

  • Online ISBN: 978-3-319-60507-4

  • eBook Packages: MedicineMedicine (R0)

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