Neurotoxicity of Copper

Bulcke, Felix; Dringen, Ralf; Scheiber, Ivo Florin

doi:10.1007/978-3-319-60189-2_16

Felix Bulcke^4,5,
Ralf Dringen^4,5 &
Ivo Florin Scheiber^4,5

Part of the book series: Advances in Neurobiology ((NEUROBIOL,volume 18))

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69 Citations
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Abstract

Copper is an essential trace metal that is required for several important biological processes, however, an excess of copper can be toxic to cells. Therefore, systemic and cellular copper homeostasis is tightly regulated, but dysregulation of copper homeostasis may occur in disease states, resulting either in copper deficiency or copper overload and toxicity. This chapter will give an overview on the biological roles of copper and of the mechanisms involved in copper uptake, storage, and distribution. In addition, we will describe potential mechanisms of the cellular toxicity of copper and copper oxide nanoparticles. Finally, we will summarize the current knowledge on the connection of copper toxicity with neurodegenerative diseases.

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Center for Biomolecular Interactions Bremen, Faculty 2 (Biology/Chemistry), University of Bremen, Bremen, Germany
Felix Bulcke, Ralf Dringen & Ivo Florin Scheiber
Center for Environmental Research and Sustainable Technology, Bremen, Germany
Felix Bulcke, Ralf Dringen & Ivo Florin Scheiber

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Felix Bulcke
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Ralf Dringen
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Ivo Florin Scheiber
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Correspondence to Ivo Florin Scheiber .

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Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, USA
Michael Aschner
Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, USA
Lucio G. Costa

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Bulcke, F., Dringen, R., Scheiber, I.F. (2017). Neurotoxicity of Copper. In: Aschner, M., Costa, L. (eds) Neurotoxicity of Metals. Advances in Neurobiology, vol 18. Springer, Cham. https://doi.org/10.1007/978-3-319-60189-2_16

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DOI: https://doi.org/10.1007/978-3-319-60189-2_16
Published: 10 September 2017
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