Advertisement

Osteoarthritis

Chapter

Abstract

Osteoarthritis (OA) is considered the most common disorder of the musculoskeletal system and the greatest cause of disability all over the world. As a consequence to the population aging, the prevalence of OA has increased. Data obtained from the Framingham study place OA at the same level of both cardiovascular diseases and chronic obstructive pulmonary disease as the major cause of chronic physical disability. Because the prevalence of OA increases with aging, coexistence with other chronic diseases is common, further increasing the impact on the quality of life of those patients. The major comorbidities of OA patients include arterial hypertension, cardiovascular disease, diabetes, and dyslipidemia. Metabolic syndrome is defined as the association of hypertension, central obesity, glucose intolerance, and hyperlipidemia. On another front, as OA is the major cause of pain in older adult patients, a population with a very high prevalence of depression, the coexistence of both diseases is frequent. Although OA is the most common disease causing physical disability, the full impact of its combination with other chronic diseases, i.e., comorbidities, on the patients has not been thoroughly addressed. This chapter will discuss osteoarthritis epidemiology, manifestations, associated comorbidities, as well as management.

Keywords

Osteoarthritis Osteoarthritis comorbidities Osteoarthritis imaging Osteoarthritis treatment Osteoarthritis and cardiovascular disease Osteoarthritis and diabetes Obesity and osteoarthritis 

References

  1. 1.
    Hochberg MC. Osteoarthritis year 2012 in review: clinical. Osteoarthr Cartil. 2012;20:1465–9.CrossRefPubMedGoogle Scholar
  2. 2.
    Bijlsma JW, Berenbaum F, Lafeber FP. Osteoarthritis: an update with relevance for clinical practice. Lancet. 2011;377:2115–26.CrossRefPubMedGoogle Scholar
  3. 3.
    Parsons C, Clynes M, Syddall H, Jagannath D, Litwit A, van der Pas S, et al. How well do radiographic, clinical and self-reported diagnoses of knee osteoarthritis agree? Findings from the Hertfordshire cohort study. Spring. 2015;4:177.CrossRefGoogle Scholar
  4. 4.
    van der Pas S, Castell MV, Cooper C, Denkinger M, Dennison EM, Edwards MH, et al. European project on osteoarthritis: design of a six-cohort study on the personal and societal burden of osteoarthritis in an older European population. BMC Musculoskelet Disord. 2013;14:138.CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Lawrence RC, Felson DT, Helmick CG, Arnaold LM, Choi H, Deyo RA, et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis Rheum. 2008;58:26–35.CrossRefPubMedPubMedCentralGoogle Scholar
  6. 6.
    Cross M, Smith E, Hoy D, Nolte S, Ackerman I, Fransen M, et al. The global burden of hip and knee osteoarthritis: estimates from the global burden of disease 2010 study. Ann Rheum Dis. 2014;73:1323–30.CrossRefPubMedGoogle Scholar
  7. 7.
    Ng M, Fleming T, Robinson M, Thompson B, Graetz N, Margono C, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the global burden of disease study 2013. Lancet. 2014;384:766–81.CrossRefPubMedPubMedCentralGoogle Scholar
  8. 8.
    Reyes C, Leyland KM, Peat G, Cooper C, Arden NK, Prieto-Alhambra D. Association between overweight and obesity and risk of clinically diagnosed knee, hip, and hand osteoarthritis: a population-based cohort study. Arthritis Rheumatol. 2016;68:1869–75.CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    Felson DT, Zhang Y, Anthony JM, Naimark A, Anderson JJ. Weight loss reduces the risk for symptomatic knee osteoarthritis in women. The Framingham study. Ann Intern Med. 1992;116:535–9.CrossRefPubMedGoogle Scholar
  10. 10.
    Gill RS, Al-Adra DP, Shi X, Sharma AM, Birch DW, Karmali S. The benefits of bariatric surgery in obese patients with hip and knee osteoarthritis: a systematic review. Obes Rev. 2011;12:1083–9.CrossRefPubMedGoogle Scholar
  11. 11.
    Hall JA, Stubbs B, Mamas AM, Myint PK, Smith TO. Association between osteoarthritis and cardiovascular disease: systematic review and meta-analysis. Eur J Prev Cardiol. 2016;23(3):938–46.CrossRefPubMedGoogle Scholar
  12. 12.
    Rahman MM, Kopec JA, Cibere J, Goldsmith CH, Anis AH. The relationship between osteoarthritis and cardiovascular disease in a population health survey: a cross-sectional study. BMJ Open. 2013;3(5):pii:e002624CrossRefGoogle Scholar
  13. 13.
    Piva SR, Susko AM, Samannaaz SK, Josbeno DA, Fitzgerald KG, FGS T. Links between osteoarthritis and diabetes: implications for management from physical activity perspective. Clin Geriatr Med. 2015;31(1):67–87.CrossRefPubMedGoogle Scholar
  14. 14.
    Eymard F, Oarsons C, Edwards MH, Petit-Dop F, Reginster JY, Bruyére O, et al. Diabetes is a risk factor for knee osteoarthritis progression. Osteoarthr Cartil. 2015;23:851–9.CrossRefPubMedGoogle Scholar
  15. 15.
    Chadha R. Revealed aspect of metabolic osteoarthritis. J Orthop. 2016;13:347–51.CrossRefPubMedGoogle Scholar
  16. 16.
    Sellam J, Berenbaum F. Is osteoarthritis a metabolic disease? Joint Bone Spine. 2013;80:568–73.CrossRefPubMedGoogle Scholar
  17. 17.
    Hamada D, Maynard R, Schott E, Drinkwater CJ, Ketz JP, Kates SL, et al. Insulin suppresses TNF-dependent early osteoarthritic changes associated with obesity and type 2 diabetes. Arthritis Rheumatol. 2016;68(6):1392–402.CrossRefPubMedPubMedCentralGoogle Scholar
  18. 18.
    Anton SD, Karabetian C, Naugle K, Buford TW. Obesity and diabetes as accelerators of functional decline; can lifestyle interventions maintain functional status in high risk older adults? Exp Gerontol. 2013;48(9):888–97. doi: 10.1016/j.exger.2013.06.007.CrossRefPubMedGoogle Scholar
  19. 19.
    Calvet J, Orellana C, Larrosa M, Navarro N, Chillaron JJ, Pedro-Botet J, et al. High prevalence of cardiovascular co-morbidities in patients with symptomatic knee or hand osteoarthritis. Scand J Rheumatol. 2015;27:1–4.Google Scholar
  20. 20.
    Hooper MH, Moskowitz R. Chapter 7. Osteoarthritis: clinical presentations. In: Kluwer W, editor. Osteoarthritis, diagnosis, and medical/surgical management. 4th ed. Philadelphia: Lippincott Williams & Wilkins. p. 139–45.Google Scholar
  21. 21.
    Sharma L. Osteoarthritis year in review 2015: clinical. Osteoarthr Cartil. 2016;24:36–48.CrossRefPubMedPubMedCentralGoogle Scholar
  22. 22.
    Zambon S, Siviero P, Denkinger M, Limongi F, Castell MV, van der Pas S, et al. Role of osteoarthritis, comorbidity, and pain in determining functional limitations in older populations: European project on osteoarthritis. Arthritis Care Res. 2016;6:801–10.CrossRefGoogle Scholar
  23. 23.
    Duclos M. Osteoarthritis, obesity and type 2 diabetes: the weight of waist circumference. Ann Phys Rehabil Med. 2016;29:157–60.CrossRefGoogle Scholar
  24. 24.
    Arkkila PE, Gautier JF. Musculoskeletal disorders in diabetes mellitus: an update. Best Prac Res Clin Rheumatol. 2004;17(6):945–70.CrossRefGoogle Scholar
  25. 25.
    Kirkman MS. Osteoarthritis progression: is diabetes a culprit? Osteoarthr Cartil. 2015;23:839–40.CrossRefPubMedGoogle Scholar
  26. 26.
    Adriaanse MC, Hanneke WD, van der Heide I, Struijs JN, Baan CA. The impact of comorbid chronic conditions on quality of life in type 2 diabetes patients. Qual Life Res. 2016;25:175–82.CrossRefPubMedGoogle Scholar
  27. 27.
    Frey N, Hügle T, Jick SS, Meier CR, Spoendlin J. Type II diabetes and incident osteoarthritis of the hand: a population-base case-control analysis. Osteoarthr Cartil. 2016;24:1535–40.CrossRefPubMedGoogle Scholar
  28. 28.
    Mathiesen A, Slatkowsky-Christensen B, Kvien TK, Berner-Hammer H, Haugen IK. Ultrasound-detected inflammation predicts radiographic progression in hand osteoarthritis after 5 years. Ann Rheum Dis. 2016; 75:825–30.Google Scholar
  29. 29.
    Jungmann PM, Kraus MS, Alizai H, Nardo L, Baum T, Nevitt MC, et al. Metabolic risk factors are associated with cartilage degradation assessed by T2 relaxation time at the knee: data from the osteoarthritis initiative. Arthritis Care Res. 2013;62(12):1942–50.CrossRefGoogle Scholar
  30. 30.
    Teichtahl AJ, Wang Y, Smith S, Wluka AE, Zhu M, Urquhart D, et al. Bone geometry of the hip is associated with obesity and early structural damage – a 3.0 T magnetic resonance imaging study of community-based adults. Arthritis Res Ther. 2015;17:112.CrossRefPubMedPubMedCentralGoogle Scholar
  31. 31.
    Brand CA, Ackerman IN, Tropea J. Chronic disease management: improving care for people with osteoarthritis. Best Prac Res Clin Rheumatol. 2014;28:119–42.CrossRefGoogle Scholar
  32. 32.
    Pedersen BK, Saltin B. Exercise as medicine-evidence for prescribing exercise as therapy in 26 different chronic diseases. Scand J Med Sci Sports. 2015;25(Suppl 3):1–72.CrossRefPubMedGoogle Scholar
  33. 33.
    de Rooij M, van der Leeden M, Cheung J, van der Esch M, Häkkinen A, Hverkamp D, et al. Efficacy of tailored exercise therapy on physical function in patients with knee osteoarthritis and comorbidity: a randomized controlled trial. Arthritis Care Res. 2016; doi: 10.1002/acr.23013.
  34. 34.
    Sartori-Cintra AR, Aikawa P, Cintra DE. Obesity versus osteoarthritis: beyond the mechanical overload. Einstein (Sao Paulo). 2014;12(3):374–9.CrossRefGoogle Scholar
  35. 35.
    Baker JF, Walsh P, Mulhall KJ. Statins: a potential role in the management of osteoarthritis? Joint Bone Spine. 2011;78:31–4.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Laboratorio de Ultrasonido Musculoesqueletico y ArticularInstituto Nacional de RehabilitaciónCiudad de MéxicoMexico
  2. 2.Department of Epidemiology and BiostatisticsVU University Medical Center, EMGO Institute for Health and Care ResearchAmsterdamThe Netherlands
  3. 3.New Kasr El Aimi Teaching Hospital, Cairo UniversityCairoEgypt

Personalised recommendations