Clinical Features in Peptic Ulcer Disease

  • Hubert Zatorski


Accurate diagnosis of peptic ulcer disease (PUD) poses a great challenge to clinicians due to nonspecific symptoms. In this chapter characterization of symptoms of PUD will be reviewed. Authors paid special attention to the most frequent symptom of PUD which is abdominal pain.

If diagnosis of PUD is delayed or management is improper, complications such as gastrointestinal bleeding and perforation of gastric outlet obstruction (GOO) may occur. In this situation, rapid and proper diagnosis is essential to implement accurate management. Hence, brief characterization of major symptoms of PUD complications is also provided below.


Complications Peptic ulcer disease Symptoms 



Gastric outlet output

H. pylori

Helicobacter pylori


Nonsteroidal anti-inflammatory drugs


Peptic ulcer disease



Hubert Zatorski is the recipient of Diamentowy Grant Program of the Polish Ministry of Science and Higher Education (No.0202/DIA/2015/44).


  1. 1.
    Kang JY, Yap I, Guan R, Tay HH. Acid perfusion of duodenal ulcer craters and ulcer pain: a controlled double blind study. Gut. 1986;27(8):942–5.CrossRefPubMedPubMedCentralGoogle Scholar
  2. 2.
    Cooke L, Hutton CF. Postbulbar duodenal ulceration. Lancet. 1958;1(7024):754–7.CrossRefPubMedGoogle Scholar
  3. 3.
    Gururatsakul M, Holloway RH, Talley NJ, Holtmann GJ. Association between clinical manifestations of complicated and uncomplicated peptic ulcer and visceral sensory dysfunction. J Gastroenterol Hepatol. 2010;25(6):1162–9.CrossRefPubMedGoogle Scholar
  4. 4.
    Wilcox CM, Clark WS. Features associated with painless peptic ulcer bleeding. Am J Gastroenterol. 1997;92(8):1289–92.PubMedGoogle Scholar
  5. 5.
    Lu CL, Chang SS, Wang SS, Chang FY, Lee SD. Silent peptic ulcer disease: frequency, factors leading to “silence,” and implications regarding the pathogenesis of visceral symptoms. Gastrointest Endosc. 2004;60(1):34–8.CrossRefPubMedGoogle Scholar
  6. 6.
    Lau JY, Sung J, Hill C, Henderson C, Howden CW, Metz DC. Systematic review of the epidemiology of complicated peptic ulcer disease: incidence, recurrence, risk factors and mortality. Digestion. 2011;84:102–13.CrossRefPubMedGoogle Scholar
  7. 7.
    Sánchez-Delgado J, Gené E, Suárez D, García-Iglesias P, Brullet E, Gallach M, et al. Has H. pylori prevalence in bleeding peptic ulcer been underestimated? A meta-regression. Am J Gastroenterol. 2011;106(3):398–405.CrossRefPubMedGoogle Scholar
  8. 8.
    Gisbert JP, Legido J, García-Sanz I, Pajares JM. Helicobacter pylori and perforated peptic ulcer. Prevalence of the infection and role of non-steroidal anti-inflammatory drugs. Dig Liver Dis. 2004;36(2):116–20.CrossRefPubMedGoogle Scholar
  9. 9.
    Behrman SW. Management of complicated peptic ulcer disease. Arch Surg. 2005;140(2):201–8.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Department of Biochemistry, Faculty of MedicineMedical University of LodzLodzPoland

Personalised recommendations