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Abdominal Sepsis pp 265–286Cite as

Antimicrobial Resistance in Intra-abdominal Infections

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Part of the book series: Hot Topics in Acute Care Surgery and Trauma ((HTACST))

Abstract

Antimicrobial resistance is a worldwide expanding phenomenon with unprecedented consequences in morbidity, mortality, and healthcare expenditures. Surgical departments follow the global alarming trends, with less than a handful antibiotics active against many contemporary bacteria with pan-drug-resistant phenotypes.

Understanding the underlying mechanisms of resistance development and the overall toll from antibiotic misuse is essential in order to effectively use antibiotics in intra-abdominal infections while limiting hazardous overprescribing behaviors. Enhancing surgeons’ knowledge on antibiotics and resistance mechanisms will maximize patients’ clinical outcomes, while potentiating the acceptance of antibiotic stewardship programs and other measures targeting the containment of the problem. This chapter will briefly review major antibiotic resistance mechanisms encountered in the most common pathogens from intra-abdominal infections, discuss risk factors for emergence of antimicrobial resistance in surgical patients and highlight the most important measures by which surgeons can confront this challenging therapeutic issue.

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Authors and Affiliations

  1. 4th Department of Internal Medicine and Infectious Diseases Unit, Attikon University General Hospital, Athens University School of Medicine, 1 Rimini st., 12462, Athens, Greece

    Garyphallia Poulakou M.D., Ph.D., Georgios Siakallis M.D. & Sotirios Tsiodras

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  1. Garyphallia Poulakou M.D., Ph.D.
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  2. Georgios Siakallis M.D.
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  3. Sotirios Tsiodras
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Correspondence to Garyphallia Poulakou M.D., Ph.D. .

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Editors and Affiliations

  1. Department of Surgery, Macerata Hospital, Macerata, Italy

    Massimo Sartelli

  2. University of Udine, Infectious Diseases Division , Udine, Italy

    Matteo Bassetti

  3. St James's University Hospital, Trinity Centre for Health Sciences , Dublin, Ireland

    Ignacio Martin-Loeches

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Poulakou, G., Siakallis, G., Tsiodras, S. (2018). Antimicrobial Resistance in Intra-abdominal Infections. In: Sartelli, M., Bassetti, M., Martin-Loeches, I. (eds) Abdominal Sepsis. Hot Topics in Acute Care Surgery and Trauma. Springer, Cham. https://doi.org/10.1007/978-3-319-59704-1_18

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