Skip to main content

Amphetamines and Other Stimulant Use

  • Chapter
  • First Online:
Consults in Obstetric Anesthesiology
  • 116 Accesses

Abstract

Stimulant abuse, particularly methamphetamine, increased dramatically among women of childbearing age between 1994 and 2006; however, the rate of abuse has plateaued since and use during pregnancy is difficult to estimate. Maternal physiologic effects are similar to that of cocaine, with sympathetic system activation during periods of acute intoxication and significant psychosis with long-term use. Poorer obstetric and neonatal outcomes to include preterm delivery, placental abruption, and small for gestational age deliveries occur; however, long-term child outcomes appear similar to that of non-stimulant-abusing women. Intra- and postpartum obstetric management are similar to that of the cocaine-abusing mother. Neuraxial blockade may be complicated by more frequent and more difficult to treat hypotension due to catecholamine depletion in the chronic non-intoxicated abuser.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Substance Abuse and Mental Health Services Administration. Results from the 2013 National Survey on Drug Use and Health: summary of national findings. NSDUH series H-48, HHS publication no. (SMA) 14-4863. Rockville: Substance Abuse and Mental Health Services Administration; 2014.

    Google Scholar 

  2. Arria AM, Derauf C, Lagasse LL, et al. Methamphetamine and other substance use during pregnancy: preliminary estimates from the Infant Development, Environment, and Lifestyle (IDEAL) study. Matern Child Health J. 2006;10:203–302.

    Article  Google Scholar 

  3. American College of Obstetricians and Gynecologists. Committee opinion number 479: methamphetamine abuse in women of reproductive age. Obstet Gynecol. 2011;117:751–5.

    Article  Google Scholar 

  4. Good MM, Solt I, Acuna JG, et al. Methamphetamine abuse during pregnancy: maternal and neonatal implications. Obstet Gynecol. 2010;116:330–4.

    Article  Google Scholar 

  5. Della Grotta S, LaGasse LL, Arria AM, et al. Patterns of methamphetamine use during pregnancy: results from the Infant Development, Environment, and Lifestyle (IDEAL) study. Matern Child Health J. 2010;14:519–27.

    Article  Google Scholar 

  6. Hyman SE. Addiction to cocaine and amphetamine. Neuron. 1996;16:901–4.

    Article  CAS  Google Scholar 

  7. Rayburn WF, Bogenschutz MP. Pharmacotherapy for pregnant women with addictions. Am J Obstet Gynecol. 2004;191:1885–97.

    Article  CAS  Google Scholar 

  8. Singer LT, Moore DG, Meeyoung O, et al. One year outcomes of prenatal exposure to MDMA and other recreational drugs. Pediatrics. 2012;130:407–13.

    Article  Google Scholar 

  9. Reynolds EW, Bada HS. Pharmacology of drugs of abuse. Obstet Gynecol Clin North Am. 2003;30:501–22.

    Article  Google Scholar 

  10. Frost EAM, Gist RS, Adriano E. Drugs, alcohol, pregnancy, and the fetal alcohol syndrome. Int Anesthesiol Clin. 2011;49:119–33.

    Article  Google Scholar 

  11. American College of Obstetricians and Gynecologists. ACOG Committee opinion no. 422: at-risk drinking and illicit drug use: ethical issues in obstetric and gynecologic practice. Obstet Gynecol. 2008;112:1449–60.

    Article  Google Scholar 

  12. Smith LM, LaGasse LL, Derauf C, et al. Prenatal methamphetamine use and neonatal neurobehavioral outcome. Neurotoxicol Teratol. 2008;24:17–23.

    Google Scholar 

  13. Lu HL, Johnson A, O’Hre ED, et al. Effects of prenatal methamphetamine exposure on verbal memory revealed with functional magnetic resonance imaging. J Dev Behav Pediatr. 2009;30:185–92.

    Article  Google Scholar 

  14. McLafferty LP, Becker M, Dresner N, et al. Guidelines for the management of pregnant women with substance abuse disorders. Psychosomatics. 2016;57:115–30.

    Article  Google Scholar 

  15. D’Apoito K. Breastfeeding and substance abuse. Clin Obstet Gynecol. 2013;56:202–11.

    Article  Google Scholar 

  16. Hanzawa S, Nemoto M, Etoh S, et al. A case of amphetamine-induced down-regulation of the beta-adrenoceptor. Mausi. 2001;50:1242–5.

    CAS  Google Scholar 

  17. Kuczkowski KM. Anesthetic implications of drug abuse in pregnancy. J Clin Anesth. 2003;15:382–94.

    Article  Google Scholar 

  18. Johnston RR, Way WL, Miller RD. Alteration of anesthetic requirement by amphetamine. Anesthesiology. 1972;36:357–63.

    Article  CAS  Google Scholar 

  19. Sullivan JT. Substance abuse and the drug addicted mother. In: Suresh MS, Segal S, Preston RL, Fernando R, Mason CL, editors. Shnider and Levinson’s anesthesia for obstetrics. 5th ed. Baltimore: Wolters Kluwer; 2013. p. 683–98.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Curtis L. Baysinger M.D. .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Baysinger, C.L. (2018). Amphetamines and Other Stimulant Use. In: Mankowitz, S. (eds) Consults in Obstetric Anesthesiology. Springer, Cham. https://doi.org/10.1007/978-3-319-59680-8_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-59680-8_6

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-59679-2

  • Online ISBN: 978-3-319-59680-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics