Epidemiology and Clinical Manifestations of Langerhans Cell Histiocytosis in Children

  • Etai Adam
  • Rima Jubran
  • Sheila Weitzman


This chapter recounts the history of classification of LCH, the association with certain risk factors and with other malignancies, and the patterns of disease reported. In it, the history of LCH as a disease is told, from classification as three different diseases to unification as a single disease with a variable presentation. The chapter goes into further detail about the variety of different manifestations in different organ systems and assesses the evidence for suspected risk factors to LCH.


History Letterer-Siwe Hand-Schüller-Christian Eosinophilic granuloma Risk factors Malignancy Pediatric 


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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.The Children’s Center for Cancer and Blood Diseases, Children’s Hospital Los AngelesLos AngelesUSA
  2. 2.Division of Haematology and Oncology, Department of PaediatricsThe Hospital for Sick Children, University of TorontoTorontoCanada

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