Abstract
One key advantage of a topical administration is the decreased risk of toxicological findings. This perceived element is generally the driving rationale for developing a topical medicine.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Brunner M, Dehghanyar P, Seigfried B, Martin W, Menke G, Müller M. Favourable dermal penetration of diclofenac after administration to the skin using a novel spray gel formulation. Br J Clin Pharmacol. 2005;60(5):573–7.
Smith DA, Di L, Kerns EH. The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery. Nat Rev Drug Discov. 2010;9(12):929–39.
Anissimov YG. Mathematical models for skin toxicology. Expert Opin Drug Metab Toxicol. 2014;10(4):551–60.
Cordero JA, Camacho M, Obach R, Domenech J, Vila L. In vitro based index of topical anti-inflammatory activity to compare a series of NSAIDs. Eur J Pharm Biopharm. 2001;51(2):135–42.
L. Trottet. Indirect measurement of skin concentration. In: Topical pharmacokinetics for a rational and effective topical drug development process, Ph.D. Thesis, University of Greenwich, 2004.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Copyright information
© 2017 Springer International Publishing AG
About this chapter
Cite this chapter
Trottet, L., Maibach, H. (2017). Assessing Therapeutic Index. In: Dermal Drug Selection and Development. Springer, Cham. https://doi.org/10.1007/978-3-319-59504-7_7
Download citation
DOI: https://doi.org/10.1007/978-3-319-59504-7_7
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-59503-0
Online ISBN: 978-3-319-59504-7
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)