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Sedation in Cardiac Surgery Intensive Care Unit

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Abstract

In this chapter, an overview is presented of ICU sedation of patients undergoing heart operation. Cardiac patients are particularly vulnerable to the side effects of sedative drugs because of the limited cardiac reserve. Furthermore, patients scheduled for cardiac surgery are becoming increasingly frailer and aged, and thus they present with several associated comorbidities, such as atherosclerosis or neurocognitive dysfunction, which put them at risk to develop postoperative delirium and cognitive disabilities. Sedation has a pivotal role in the cardiac surgery setting, not only for the increasing need to calm delirious patients but also for its potential role, if not correctly managed, in inducing delirium itself. Nevertheless, the advances made by cardiac surgery in the last decades allowed to wean patients early in the postoperative period. Therefore, starting with the assumption that outcome is better if sedation is maintained not too deep and for the shortest time needed, the fast-track model diffused widely in the last 20 years and is nowadays the most common weaning strategy also after heart operations. Although it is not time yet to decide what sedative drug is better for cardiac patients, the most commonly used sedatives in this setting are also discussed.

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References

  1. Vincent JL, Shehabi Y, Walsh TS, et al. Comfort and patient-centred care without excessive sedation: the eCASH concept. Intensive Care Med. 2016;42:962–71.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Hanley PJ, ter Keurs HE, Cannell MB. Excitation-contraction coupling in the heart and the negative inotropic action of volatile anesthetics. Anesthesiology. 2004;101:999–1014.

    Article  PubMed  Google Scholar 

  3. Bignami E, Biondi-Zoccai G, Landoni G, et al. Volatile anesthetics reduce mortality in cardiac surgery. J Cardiothorac Vasc Anesth. 2009;23:594–9.

    Article  PubMed  Google Scholar 

  4. Jerath A, Parotto M, Wasowicz M, et al. Volatile anesthetics. Is a new player emerging in critical care sedation? Am J Respir Crit Care Med. 2016;193:1202–12.

    Article  CAS  PubMed  Google Scholar 

  5. Marcos-Vidal JM, González R, Garcia C, et al. Sedation with sevoflurane in postoperative cardiac surgery: influence on troponin T and creatinine values. Heart Lung Vessel. 2014;6:33–42.

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Reves JG, Glass P, Lubarsky DA, et al. Intravenous anesthetics. In: Miller RD, Eriksson LI, Fleischer LA, et al., editors. Miller’s anesthesia. 7th ed. Philadelphia: Churchill Livingstone; 2010. p. 719–68.

    Chapter  Google Scholar 

  7. Bovill JG. Intravenous anesthesia for the patient with left ventricular dysfunction. Semin Cardiothorac Vasc Anesth. 2006;10:43–8.

    Article  CAS  PubMed  Google Scholar 

  8. Fraser GL, Devlin JW, Worby CP, et al. Benzodiazepine versus nonbenzodiazepine-based sedation for mechanically ventilated, critically ill adults: a systematic review and meta-analysis of randomized trials. Crit Care Med. 2013;41:S30–8.

    Article  CAS  PubMed  Google Scholar 

  9. Silbert BS, Myles PS. Is fast-track cardiac anesthesia now the global standard of care? Anesth Analg. 2009;108:689–91.

    Article  PubMed  Google Scholar 

  10. Lin Y, Chen J, Wang Z. Meta-analysis of factors which influence delirium following cardiac surgery. J Card Surg. 2012;27(4):481–92.

    Article  PubMed  Google Scholar 

  11. Svircevic V, Nierich AP, Moons KG, et al. Fast-track anesthesia and cardiac surgery: a retrospective cohort study of 7989 patients. Anesth Analg. 2009;108:727–33.

    Article  PubMed  Google Scholar 

  12. Wong WT, Lai VK, Chee YE, et al. Fast-track cardiac care for adult cardiac surgical patients. Cochrane Database Syst Rev. 2016;9:CD003587. [Epub ahead of print]

    PubMed  Google Scholar 

  13. Myles PS, Daly DJ, Djaiani G, et al. A systematic review of the safety and effectiveness of fast-track cardiac anesthesia. Anesthesiology. 2003;99:982–7.

    Article  PubMed  Google Scholar 

  14. Probst S, Cech C, Haentschel D, et al. A specialized post anaesthetic care unit improves fast-track management in cardiac surgery: a prospective randomized trial. Crit Care. 2014;18:468.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Haanschoten MC, Van Straten AH, Ter Woorst JF, et al. Fast-track practice in cardiac surgery: results and predictors of outcome. Interact Cardiovasc Thorac Surg. 2012;15:989–94.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Norkiene I, Ringaitiene D, Misiuriene I, et al. Incidence and precipitating factors of delirium after coronary artery bypass grafting. Scand Cardiovasc J. 2007;41:180–5.

    Article  PubMed  Google Scholar 

  17. Rudolph JL, Jones RN, Levkoff SE, et al. Derivation and validation of a preoperative prediction rule for delirium after cardiac surgery. Circulation. 2009;119:229–36.

    Article  PubMed  Google Scholar 

  18. Stransky M, Schmidt C, Ganslmeier P, et al. Hypoactive delirium after cardiac surgery as an independent risk factor for prolonged mechanical ventilation. J Cardiothorac Vasc Anesth. 2011;25:968–74.

    Article  PubMed  Google Scholar 

  19. Andrejaitiene J, Sirvinskas E. Early post-cardiac surgery delirium risk factors. Perfusion. 2012;27:105–12.

    Article  CAS  PubMed  Google Scholar 

  20. Koster S, Hensens AG, Schuurmans MJ, et al. Consequences of delirium after cardiac operations. Ann Thorac Surg. 2012;93:705–11.

    Article  PubMed  Google Scholar 

  21. Lahariya S, Grover S, Bagga S, et al. Delirium in patients admitted to a cardiac intensive care unit with cardiac emergencies in a developing country: incidence, prevalence, risk factor and outcome. Gen Hosp Psychiatry. 2014;36:156–64.

    Article  PubMed  Google Scholar 

  22. Hudetz JA, Iqbal Z, Gandhi SD, et al. Postoperative delirium and short-term cognitive dysfunction occur more frequently in patients undergoing valve surgery with or without coronary artery bypass graft surgery compared with coronary artery bypass graft surgery alone: results of a pilot study. J Cardiothorac Vasc Anesth. 2011;25:811–6.

    Article  PubMed  Google Scholar 

  23. Liu Z, Pang X, Zhang X, et al. Incidence and risk factors of delirium in patients after type A aortic dissection surgery. J Cardiothorac Vasc Anesth. 2016. https://doi.org/10.1053/j.jvca.2016.11.011.

  24. Sieber FE, Zakriya KJ, Gottschalk A, et al. Sedation depth during spinal anesthesia and the development of postoperative delirium in elderly patients undergoing hip fracture repair. Mayo Clin Proc. 2010;85:18–26.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Burkhart CS, Dell-Kuster S, Gamberini M, et al. Modifiable and nonmodifiable risk factors for postoperative delirium after cardiac surgery with cardiopulmonary bypass. J Cardiothorac Vasc Anesth. 2010;24:555–9.

    Article  PubMed  Google Scholar 

  26. Tse L, Schwarz SK, Bowering JB, et al. Incidence of and risk factors for delirium after cardiac surgery at a quaternary care center: a retrospective cohort study. J Cardiothorac Vasc Anesth. 2015;29:1472–9.

    Article  PubMed  Google Scholar 

  27. Hudetz JA, Patterson KM, Iqbal Z, et al. Ketamine attenuates delirium after cardiac surgery with cardiopulmonary bypass. J Cardiothorac Vasc Anesth. 2009;23:651–7.

    Article  CAS  PubMed  Google Scholar 

  28. Pasin L, Landoni G, Nardelli P, et al. Dexmedetomidine reduces the risk of delirium, agitation and confusion in critically ill patients: a meta-analysis of randomized controlled trials. J Cardiothorac Vasc Anesth. 2014;28:1459–66.

    Article  CAS  PubMed  Google Scholar 

  29. Redelmeier DA, Thiruchelvam D, Daneman N. Delirium after elective surgery among elderly patients taking statins. CMAJ. 2008;179:645–52.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Arora RC, Djaiani G, Rudolph JL. Detection, prevention, and management of delirium in the critically ill cardiac patient and patients who undergo cardiac procedures. Can J Cardiol. 2017;33:80–7.

    Article  PubMed  Google Scholar 

  31. Aldecoa C, Bettelli G, Bilotta F, et al. European Society of Anaesthesiology evidence-based and consensus-based guidelines on postoperative delirium. Eur J Anaesthesiol. 2017;9. https://doi.org/10.1097/EJA.0000000000000594.

  32. Barr J, Fraser GL, Puntillo K, et al. Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit. Crit Care Med. 2013;41:263–306.

    Article  PubMed  Google Scholar 

  33. Artemiou P, Bily B, Bilecova-Rabajdova M, et al. Melatonin treatment in the prevention of postoperative delirium in cardiac surgery patients. Kardiochir Torakochirurgia Pol. 2015;12(2):126–33.

    PubMed  PubMed Central  Google Scholar 

  34. Prakanrattana U, Prapaitrakool S. Efficacy of risperidone for prevention of postoperative delirium in cardiac surgery. Anaesth Intensive Care. 2007;35:714–9.

    CAS  PubMed  Google Scholar 

  35. Atalan N, Efe Sevim M, Akgün S, et al. Morphine is a reasonable alternative to haloperidol in the treatment of postoperative hyperactive-type delirium after cardiac surgery. J Cardiothorac Vasc Anesth. 2013;27:933–8.

    Article  CAS  PubMed  Google Scholar 

  36. Tagarakis GI, Voucharas C, Tsolaki F, et al. Ondansetron versus haloperidol for the treatment of postcardiotomy delirium: a prospective, randomized, double-blinded study. J Cardiothorac Surg. 2012;7:25.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Hakim SM, Othman AI, Naoum DO. Early treatment with risperidone for subsyndromal delirium after on-pump cardiac surgery in the elderly: a randomized trial. Anesthesiology. 2012;116:987–97.

    Article  CAS  PubMed  Google Scholar 

  38. Dieleman JM, Nierich AP, Rosseel PM, et al. Dexamethasone for Cardiac Surgery (DECS) Study Group. Intraoperative high-dose dexamethasone for cardiac surgery: a randomized controlled trial. JAMA. 2012;308:1761–7.

    Article  PubMed  Google Scholar 

  39. Gamberini M, Bolliger D, Lurati Buse GA, et al. Rivastigmine for the prevention of postoperative delirium in elderly patients undergoing elective cardiac surgery—a randomized controlled trial. Crit Care Med. 2009;37:1762–8.

    Article  CAS  PubMed  Google Scholar 

  40. Jacobi J, Fraser GL, Coursin DB, et al. Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult. Crit Care Med. 2002;30:119–41.

    Article  PubMed  Google Scholar 

  41. Tisdale JE, Rasty S, Padhi ID, et al. The effect of intravenous haloperidol on QT interval dispersion in critically ill patients: comparison with QT interval prolongation for assessment of risk of Torsades de Pointes. J Clin Pharmacol. 2001;41:1310–8.

    Article  CAS  PubMed  Google Scholar 

  42. Djaiani G, Silverton N, Fedorko L, et al. Dexmedetomidine versus propofol sedation reduces delirium after cardiac surgery: a randomized controlled trial. Anesthesiology. 2016;124:362–8.

    Article  CAS  PubMed  Google Scholar 

  43. Chen K, Lu Z, Xin YC, et al. Alpha-2 agonists for long-term sedation during mechanical ventilation in critically ill patients. Cochrane Database Syst Rev. 2015;1:CD010269.

    PubMed  Google Scholar 

  44. Chorney SR, Gooch ME, Oberdier MT, et al. The safety and efficacy of dexmedetomidine for postoperative sedation in the cardiac surgery intensive care unit. HSR Proc Intensive Care Cardiovasc Anesth. 2013;5:17–24.

    CAS  PubMed  PubMed Central  Google Scholar 

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Correspondence to Sergio Bevilacqua .

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Bevilacqua, S., Galeotti, I. (2018). Sedation in Cardiac Surgery Intensive Care Unit. In: De Gaudio, A., Romagnoli, S. (eds) Critical Care Sedation. Springer, Cham. https://doi.org/10.1007/978-3-319-59312-8_15

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  • DOI: https://doi.org/10.1007/978-3-319-59312-8_15

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