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Estimation of Brain Network Atlases Using Diffusive-Shrinking Graphs: Application to Developing Brains

  • Islem Rekik
  • Gang Li
  • Weili Lin
  • Dinggang Shen
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 10265)

Abstract

Many methods have been developed to spatially normalize a population of brain images for estimating a mean image as a population- average atlas. However, methods for deriving a network atlas from a set of brain networks sitting on a complex manifold are still absent. Learning how to average brain networks across subjects constitutes a key step in creating a reliable mean representation of a population of brain networks, which can be used to spot abnormal deviations from the healthy network atlas. In this work, we propose a novel network atlas estimation framework, which guarantees that the produced network atlas is clean (for tuning down noisy measurements) and well-centered (for being optimally close to all subjects and representing the individual traits of each subject in the population). Specifically, for a population of brain networks, we first build a tensor, where each of its frontal-views (i.e., frontal matrices) represents a connectivity network matrix of a single subject in the population. Then, we use tensor robust principal component analysis for jointly denoising all subjects’ networks through cleaving a sparse noisy network population tensor from a clean low-rank network tensor. Second, we build a graph where each node represents a frontal-view of the unfolded clean tensor (network), to leverage the local manifold structure of these networks when fusing them. Specifically, we progressively shrink the graph of networks towards the centered mean network atlas through non-linear diffusion along the local neighbors of each of its nodes. Our evaluation on the developing functional and morphological brain networks at 1, 3, 6, 9 and 12 months of age has showed a better centeredness of our network atlases, in comparison with the baseline network fusion method. Further cleaning of the population of networks produces even more centered atlases, especially for the noisy functional connectivity networks.

Keywords

Functional Connectivity Brain Network Brain Connectivity Individual Network Global Center 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

This work is also supported in part by National Institutes of Health grants (MH100217, MH108914 and MH107815) a grant from NIH (1U01MH110274) and UNC/UMN Baby Connectome Project Consortium.

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Islem Rekik
    • 1
  • Gang Li
    • 2
  • Weili Lin
    • 2
  • Dinggang Shen
    • 2
  1. 1.CVIP, Computing, School of Science and EngineeringUniversity of DundeeDundeeUK
  2. 2.Department of Radiology and BRICUniversity of North Carolina at Chapel HillChapel HillUSA

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