Abstract
Finding the common structural brain connectivity network for a given population is an open problem, crucial for current neuroscience. Recent evidence suggests there’s a tightly connected network shared between humans. Obtaining this network will, among many advantages, allow us to focus cognitive and clinical analyses on common connections, thus increasing their statistical power. In turn, knowledge about the common network will facilitate novel analyses to understand the structure-function relationship in the brain.
In this work, we present a new algorithm for computing the core structural connectivity network of a subject sample combining graph theory and statistics. Our algorithm works in accordance with novel evidence on brain topology. We analyze the problem theoretically and prove its complexity. Using 309 subjects, we show its advantages when used as a feature selection for connectivity analysis on populations, outperforming the current approaches.
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Acknowledgements
Authors acknowledge funding from ERC Advanced Grant agreement No. 694665: CoBCoM - Computational Brain Connectivity Mapping and the ANR-NSF grant NeuroRef.
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Lascano, N., Gallardo-Diez, G., Deriche, R., Mazauric, D., Wassermann, D. (2017). Extracting the Groupwise Core Structural Connectivity Network: Bridging Statistical and Graph-Theoretical Approaches. In: Niethammer, M., et al. Information Processing in Medical Imaging. IPMI 2017. Lecture Notes in Computer Science(), vol 10265. Springer, Cham. https://doi.org/10.1007/978-3-319-59050-9_30
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DOI: https://doi.org/10.1007/978-3-319-59050-9_30
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