Complications in the Cosmetic Use of Botulinum Toxin Type A: Prevention and Management
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Botulinum toxin type A (BTX-A) has become the most frequently requested nonsurgical procedure performed around the world. The use of BTX-A in cosmetics has expanded greatly since its approval by the Food and Drug Administration for reduction of glabellar rhytids. Experienced clinicians have been using BTX-A in other areas off-label to improve the appearance of rhytids and facial harmony. Adverse effects associated with BTX-A are rare and tend to be mild and temporary, such as bruising, swelling, and pain at injection sites. More serious complications, such as brow ptosis or eyelid ptosis, can occur. These complications can be minimized by a thorough understanding of the anatomy of the face and careful injection technique, which will be outlined in this article.
- 5.American Society of Plastic Surgeons. New statistics reflect the changing face of plastic surgery. https://www.plasticsurgery.org/news/press-releases/new-statistics-reflect-the-changing-face-of-plastic-surgery
- 6.Tremaine AM, McCullough JL. Botulinum toxin type A for the management of glabellar rhytids. Clin Cosmet Investig Dermatol. 2013;3:15–23.Google Scholar
- 8.Carruthers JDA, Carruthers JA. Treatment of glabellar frown lines with C. Botulinum A exotoxin. In: Carruthers J, Carruthers A. Botulinum toxin in facial rejuvenation: an update.Google Scholar
- 9.Botox Cosmetic OnabotulinumtoxinA: full prescribing information. Allergan Inc. 2010. http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/103000s5236lbl.pdf
- 10.Xeomin IncobotulinumtoxinA: full prescribing information. Merz Pharmaceuticals, LLC. 2010. http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/125360lbl.pdf
- 11.Dysport AbobotulinumtoxinA: full prescribing information. Ipsen Pharmaceuticals and Galderma Laboratories. 2016. https://www.dysport.com/pdfs/Dysport_Full_Prescribing_Information.pdf.
- 15.Rzany B, Zielke H. Safety of botulinum toxin in aesthetic medicine. In: Botulinum toxin in aesthetic medicine. Berlin: Springer; 2007. p. 119–25.Google Scholar
- 16.Klein AW. Complications, adverse reactions, and insights with the use of botulinum toxin. Dermatol Surg. 2003;29(5):548–56.Google Scholar
- 17.Brodsky MA, Swope DM, Grimes D. Diffusion of botulinum toxins. In: Louis ED, editor. Tremor Other Hyperkinet Mov. 2012;2:tre-02-85-417-1.Google Scholar
- 18.Matarasso A, Shafer D. Botulinum toxin injections for facial rejuvenation. In: Nahai F, editor. The art of aesthetic surgery: principles and techniques. 2nd ed. St Louis, MO: Quality Medicine Publishing; 2011. p. 243–6. (4 in Qaquish).Google Scholar