Abstract
Methods from nonlinear dynamics have shown new insights into alterations of the cardiovascular system under various physiological and pathological conditions, and thus providing additional prognostic information. In this chapter prominent complexity methods of non-linear dynamics as symbolic dynamics, Poincaré plot analyses, and compression entropy are introduced and their algorithmic implementations and application examples in clinical trials are provided. Especially, we will give their basic theoretical background, their main features and demonstrate their usefulness in different applications in the field of cardiovascular and cardiorespiratory time series analyses.
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References
Voss, A., Schulz, S., Schroeder, R., Baumert, M., Caminal, P.: Methods derived from nonlinear dynamics for analysing heart rate variability. Philos. Transact. A Math. Phys. Eng. Sci. 367, 277–296 (2009)
Porta, A., Tobaldini, E., Guzzetti, S., Furlan, R., Montano, N., Gnecchi-Ruscone, T.: Assessment of cardiac autonomic modulation during graded head-up tilt by symbolic analysis of heart rate variability. Am. J. Physiol. Heart Circ. Physiol. 293, H702–H708 (2007)
Cysarz, D., Porta, A., Montano, N., Leeuwen, P.V., Kurths, J., Wessel, N.: Quantifying heart rate dynamics using different approaches of symbolic dynamics. Eur. Phys. J. Spec. Top. 222, 487–500 (2013)
Baumert, M., Walther, T., Hopfe, J., Stepan, H., Faber, R., Voss, A.: Joint symbolic dynamic analysis of beat-to-beat interactions of heart rate and systolic blood pressure in normal pregnancy. Med. Biol. Eng. Comput. 40, 241–245 (2002)
Schulz, S., Haueisen, J., Bar, K.J., Andreas, V.: High-resolution joint symbolic analysis to enhance classification of the cardiorespiratory system in patients with schizophrenia and their relatives. Philos. Trans. A Math. Phys. Eng. Sci. 373, 20140098 (2015)
Voss, A., Kurths, J., Kleiner, H.J., Witt, A., Wessel, N., Saparin, P., et al.: The application of methods of non-linear dynamics for the improved and predictive recognition of patients threatened by sudden cardiac death. Cardiovasc. Res. 31, 419–433 (1996)
Wackermann, J., Lehmann, D., Michel, C.M., Strik, W.K.: Adaptive segmentation of spontaneous EEG map series into spatially defined microstates. Int. J. Psychophysiol. 14, 269–283 (1993)
Beim Graben, P., Hutt, A.: Detecting recurrence domains of dynamical systems by symbolic dynamics. Phys. Rev. Lett. 110, 154101 (2013)
Schindler, K., Gast, H., Stieglitz, L., Stibal, A., Hauf, M., Wiest, R., et al.: Forbidden ordinal patterns of periictal intracranial EEG indicate deterministic dynamics in human epileptic seizures. Epilepsia. 52, 1771–1780 (2011)
Hively, L.M., Protopopescu, V.A., Munro, N.B.: Enhancements in epilepsy forewarning via phase-space dissimilarity. J. Clin. Neurophysiol. 22, 402–409 (2005)
Mashour, G.A.: Cognitive unbinding: a neuroscientific paradigm of general anesthesia and related states of unconsciousness. Neurosci. Biobehav. Rev. 37, 2751–2759 (2013)
Staniek, M., Lehnertz, K.: Symbolic transfer entropy: inferring directionality in biosignals. Biomed. Tech. (Berl). 54, 323–328 (2009)
Voss, A., Schulz, S., Schroeder, R.: Monitoring in cardiovascular disease patients by nonlinear biomedical signal processing. Conf. Proc. IEEE Eng. Med. Biol. Soc. 2011, 6564–6567 (2011)
Schulz, S., Bolz, M., Bar, K.J., Voss, A.: Central- and autonomic nervous system coupling in schizophrenia. Philos. Trans. A Math. Phys. Eng. Sci. 374, 20150178 (2016)
Porta, A., Baumert, M., Cysarz, D., Wessel, N.: Enhancing dynamical signatures of complex systems through symbolic computation. Philos. Trans. A Math. Phys. Eng. Sci. 373, 20140099 (2015)
Khandoker, A.H., Karmakar, C., Brennan, M., Palaniswami, M., Voss, A.: Poincaré plot methods for heart rate variability analysis. Springer, London (2013)
Kamen, P.W., Krum, H., Tonkin, A.M.: Poincare plot of heart rate variability allows quantitative display of parasympathetic nervous activity in humans. Clin. Sci. (Lond.) 91, 201–208 (1996)
Weiss, J.N., Garfinkel, A., Spano, M.L., Ditto, W.L.: Chaos and chaos control in biology. J. Clin. Invest. 93, 1355–1360 (1994)
Babloyantz, A., Destexhe, A.: Is the normal heart a periodic oscillator? Biol. Cybern. 58, 203–211 (1988)
Woo, M.A., Stevenson, W.G., Moser, D.K., Trelease, R.B., Harper, R.M.: Patterns of beat-to-beat heart rate variability in advanced heart failure. Am. Heart J. 123, 704–710 (1992)
Brennan, M., Palaniswami, M., Kamen, P.: Poincare plot interpretation using a physiological model of HRV based on a network of oscillators. Am. J. Physiol. Heart Circ. Physiol. 283, H1873–H1886 (2002)
Kamen, P.W., Tonkin, A.M.: Application of the Poincare plot to heart rate variability: a new measure of functional status in heart failure. Aust. NZ J. Med. 25, 18–26 (1995)
Laitio, T.T., Huikuri, H.V., Kentala, E.S., Makikallio, T.H., Jalonen, J.R., Helenius, H., et al.: Correlation properties and complexity of perioperative RR-interval dynamics in coronary artery bypass surgery patients. Anesthesiology. 93, 69–80 (2000)
Kleiger, R.E., Stein, P.K., Bigger Jr., J.T.: Heart rate variability: measurement and clinical utility. Ann. Noninvasive Electrocardiol. 10, 88–101 (2005)
Brennan, M., Palaniswami, M., Kamen, P.: Do existing measures of Poincare plot geometry reflect nonlinear features of heart rate variability? I.E.E.E. Trans. Biomed. Eng. 48, 1342–1347 (2001)
Voss, A., Fischer, C., Schroeder, R., Figulla, H.R., Goernig, M.: Segmented Poincare plot analysis for risk stratification in patients with dilated cardiomyopathy. Methods Inf. Med. 49, 511–515 (2010)
Voss, A., Fischer, C., Schroeder, R., Figulla, H.R., Goernig, M.: Lagged segmented Poincare plot analysis for risk stratification in patients with dilated cardiomyopathy. Med. Biol. Eng. Comput. 50, 727–736 (2012)
Tulppo, M.P., Makikallio, T.H., Takala, T.E., Seppanen, T., Huikuri, H.V.: Quantitative beat-to-beat analysis of heart rate dynamics during exercise. Am. J. Phys. 271, H244–H252 (1996)
Rajendra Acharya, U., Joseph, K.P., Kannathal, N., Lim, C.M., Suri, J.S.: Heart rate variability: a review. Med. Biol. Eng. Comput. 44, 1031–1051 (2006)
Tulppo, M.P., Makikallio, T.H., Seppanen, T., Airaksinen, J.K., Huikuri, H.V.: Heart rate dynamics during accentuated sympathovagal interaction. Am. J. Phys. 274, H810–H816 (1998)
Fischer, C., Seeck, A., Schroeder, R., Goernig, M., Schirdewan, A., Figulla, H.R., et al.: QT variability improves risk stratification in patients with dilated cardiomyopathy. Physiol. Meas. 36, 699–713 (2015)
Stein, P.K., Reddy, A.: Non-linear heart rate variability and risk stratification in cardiovascular disease. Ind. Pacing Electrophysiol. J. 5, 210–220 (2005)
Rydberg, A., Karlsson, M., Hornsten, R., Wiklund, U.: Can analysis of heart rate variability predict arrhythmia in children with Fontan circulation? Pediatr. Cardiol. 29, 50–55 (2008)
Porta, A., Guzzetti, S., Montano, N., Furlan, R., Pagani, M., Malliani, A., et al.: Entropy, entropy rate, and pattern classification as tools to typify complexity in short heart period variability series. I.E.E.E. Trans. Biomed. Eng. 48, 1282–1291 (Nov 2001)
Baumert, M., Voss, A., Javorka, M.: Compression based entropy estimation of heart rate variability on multiple time scales. Conf. Proc. IEEE Eng. Med. Biol. Soc. 2013, 5037–5040 (2013)
Ziv, J., Lempel, A.: Universal algorithm for sequential data compression. IEEE Trans. Inf. Ther. 23, 337–343 (1977)
Baumert, M., Baier, V., Haueisen, J., Wessel, N., Meyerfeldt, U., Schirdewan, A., et al.: Forecasting of life threatening arrhythmias using the compression entropy of heart rate. Methods Inf. Med. 43, 202–206 (2004)
Van Leeuwen, P., Cysarz, D., Edelhauser, F., Gronemeyer, D.: Heart rate variability in the individual fetus. Auton. Neurosci. 178, 24–28 (2013)
Boettger, M.K., Schulz, S., Berger, S., Tancer, M., Yeragani, V.K., Voss, A., et al.: Influence of age on linear and nonlinear measures of autonomic cardiovascular modulation. Ann. Noninvasive Electrocardiol. 15, 165–174 (2010)
Voss, A., Schroeder, R., Heitmann, A., Peters, A., Perz, S.: Short-term heart rate variability--influence of gender and age in healthy subjects. PLoS One. 10, e0118308 (2015)
Porta, A., Faes, L., Bari, V., Marchi, A., Bassani, T., Nollo, G., et al.: Effect of age on complexity and causality of the cardiovascular control: comparison between model-based and model-free approaches. PLoS One. 9, e89463 (2014)
Javorka, M., Trunkvalterova, Z., Tonhajzerova, I., Javorkova, J., Javorka, K., Baumert, M.: Short-term heart rate complexity is reduced in patients with type 1 diabetes mellitus. Clin. Neurophysiol. 119, 1071–1081 (2008)
Bär, K.J., Boettger, M.K., Koschke, M., Schulz, S., Chokka, P., Yeragani, V.K., et al.: Non-linear complexity measures of heart rate variability in acute schizophrenia. Clin. Neurophysiol. 118, 2009–2015 (2007)
Schulz, S., Koschke, M., Bär, K.J., Voss, A.: The altered complexity of cardiovascular regulation in depressed patients. Physiol. Meas. 31, 303–321 (2010)
Schulz, S., Ritter, J., Oertel, K., Witt, K., Bär, K.J., Guntinas-Lichius, O., et al.: Altered autonomic regulation as a cardiovascular risk marker for patients with sudden sensorineural hearing loss. Otol. Neurotol. 35, 1720–1729 (2014)
Bari, V., Valencia, J.F., Vallverdu, M., Girardengo, G., Marchi, A., Bassani, T., et al.: Multiscale complexity analysis of the cardiac control identifies asymptomatic and symptomatic patients in long QT syndrome type 1. PLoS One. 9, e93808 (2014)
Baumert, M., Javorka, M., Seeck, A., Faber, R., Sanders, P., Voss, A.: Multiscale entropy and detrended fluctuation analysis of QT interval and heart rate variability during normal pregnancy. Comput. Biol. Med. 42, 347–352 (2012)
Bär, K.J., Koschke, M., Berger, S., Schulz, S., Tancer, M., Voss, A., et al.: Influence of olanzapine on QT variability and complexity measures of heart rate in patients with schizophrenia. J. Clin. Psychopharmacol. 28, 694–698 (2008)
Porta, A., Guzzetti, S., Montano, N., Pagani, M., Somers, V., Malliani, A., et al.: Information domain analysis of cardiovascular variability signals: evaluation of regularity, synchronisation and co-ordination. Med. Biol. Eng. Comput. 38, 180–188 (2000)
Bär, K.J., Schuhmacher, A., Hofels, S., Schulz, S., Voss, A., Yeragani, V.K., et al.: Reduced cardio-respiratory coupling after treatment with nortriptyline in contrast to S-citalopram. J. Affect. Disord. 127, 266–273 (2010)
Ebert, A., Jochum, T., Ritter, J., Boettger, M.K., Schulz, S., Voss, A., et al.: Does parasympathetic modulation prior to ECT treatment influence therapeutic outcome? Prog. Neuro-Psychopharmacol. Biol. Psychiatry. 34, 1174–1180 (2010)
Faes, L., Porta, A., Rossato, G., Adami, A., Tonon, D., Corica, A., et al.: Investigating the mechanisms of cardiovascular and cerebrovascular regulation in orthostatic syncope through an information decomposition strategy. Auton. Neurosci. 178, 76–82 (2013)
Hadamard, J.: Les surfaces à courbures opposées et leurs lignes géodésiques. J. Math. Pures Appl. Ser. V, 27–73 (1898)
Morsem, M., Hedlund, G.A.: Symbolic dynamics. Amer. J. Math. 60, 815–866 (1938)
Aizawa, Y.: Symbolic dynamics approach to intermittent chaos. Prog. Theor. Phys. 70, 1249–1263 (1983)
Hao, B.L.: Elementary symbolic dynamics and chaos in dissipative systems. World Scientific Publishing, Singapore (1990)
Paulus, M.P., Geyer, M.A., Gold, L.H., Mandell, A.J.: Application of entropy measures derived from the ergodic theory of dynamical systems to rat locomotor behavior. Proc. Natl. Acad. Sci. U. S. A. 87, 723–727 (1990)
Voss, A., Dietz, R., Fiehring, H., Kleiner, H.J., Kurths, J., Saparin, P., et al.: High resolution ECG, heart rate variability and nonlinear dynamics: tools for high risk stratification. Comput. Cardiol. 261–264 (1993)
Kurths, J., Voss, A., Saparin, P., Witt, A., Kleiner, H.J., Wessel, N.: Quantitative analysis of heart rate variability. Chaos. 5, 88–94 (1995)
Voss, A., Hnatkova, K., Wessel, N., Kurths, J., Sander, A., Schirdewan, A., et al.: Multiparametric analysis of heart rate variability used for risk stratification among survivors of acute myocardial infarction. Pacing Clin. Electrophysiol. 21, 186–192 (1998)
Voss, A., Schroeder, R., Truebner, S., Goernig, M., Figulla, H.R., Schirdewan, A.: Comparison of nonlinear methods symbolic dynamics, detrended fluctuation, and Poincare plot analysis in risk stratification in patients with dilated cardiomyopathy. Chaos. 17, 015120 (2007)
Żebrowski, J.J., Poplawska, W., Baranowski, R., Buchner, T.: Symbolic dynamics and complexity in a physiological time series. Chaos, Solitons Fractals. 11, 1061–1075. %@ 0960–0779 (2000)
Shannon, C.E.: A mathematical theory of communication. Bell Syst. Tech. J. 27, 379–423 and 623–656 (1948)
Rényi, A.: On measures of entropy and information. Proc. Fourth Berkeley Symp. Math. Stat. Probability. 1, 547–561 (1961)
Wessel, N., Brückner, C., Malberg, H., Schumann, A., Reinsperger, F., Osterziel, K., et al.: Long-term symbolic dynamics for heart rate variability analysis in patients with dilated cardiomyopathy. Cardiomyopathy. Computers in Cardiology. 26, 253–256 (1999)
Guzzetti, S., Borroni, E., Garbelli, P.E., Ceriani, E., Della Bella, P., Montano, N., et al.: Symbolic dynamics of heart rate variability: a probe to investigate cardiac autonomic modulation. Circulation. 112, 465–470 (2005)
Porta, A., Faes, L., Mase, M., D'Addio, G., Pinna, G.D., Maestri, R., et al.: An integrated approach based on uniform quantization for the evaluation of complexity of short-term heart period variability: application to 24 h Holter recordings in healthy and heart failure humans. Chaos. 17, 015117 (2007)
Heitmann, A., Huebner, T., Schroeder, R., Perz, S., Voss, A.: Multivariate short-term heart rate variability: a pre-diagnostic tool for screening heart disease. Med. Biol. Eng. Comput. 49, 41–50 (2011)
Voss, A., Schroeder, R., Caminal, P., Vallverdú, M., Brunel, H., Cygankiewicz, I., et al.: Segmented symbolic dynamics for risk stratification in patients with ischemic heart failure. Cardiovasc. Eng. Technol. 1, 290–298 (2010)
Cysarz, D., Van Leeuwen, P., Edelhauser, F., Montano, N., Somers, V.K., Porta, A.: Symbolic transformations of heart rate variability preserve information about cardiac autonomic control. Physiol. Meas. 36, 643–657 (2015)
Schulz, S., Adochiei, F.C., Edu, I.R., Schroeder, R., Costin, H., Bär, K.J., et al.: Cardiovascular and cardiorespiratory coupling analyses: a review. Philos. Trans. A Math. Phys. Eng. Sci. 371, 20120191 (2013)
Baumert, M., Baier, V., Truebner, S., Schirdewan, A., Voss, A.: Short- and long-term joint symbolic dynamics of heart rate and blood pressure in dilated cardiomyopathy. I.E.E.E. Trans. Biomed. Eng. 52, 2112–2115 (2005)
Schulz, S., Tupaika, N., Berger, S., Haueisen, J., Bär, K.J., Voss, A.: Cardiovascular coupling analysis with high-resolution joint symbolic dynamics in patients suffering from acute schizophrenia. Physiol. Meas. 34, 883–901 (2013)
Kabir, M.M., Saint, D.A., Nalivaiko, E., Abbott, D., Voss, A., Baumert, M.: Quantification of cardiorespiratory interactions based on joint symbolic dynamics. Ann. Biomed. Eng. 39, 2604–2614 (Oct 2011)
Baumert, M., Javorka, M., Kabir, M.: Joint symbolic dynamics for the assessment of cardiovascular and cardiorespiratory interactions. Philos. Trans. A Math. Phys. Eng. Sci. 373, 20140097 (2015)
Schulz, S., Bär, K.J., Voss, A.: Analyses of heart rate, respiration and cardiorespiratory coupling in patients with schizophrenia. Entropy. 17, 483–501 (2015)
Schulz, S., Haueisen, J., Bär, K.J., Voss, A.: Quantification of cardiorespiratory coupling in acute schizophrenia applying high resolution joint symbolic dynamics. In: Computing in Cardiology Conference (CinC), pp. 101–104. Zaragoza, Spain (2013)
Bertinieri, G., Di Rienzo, M., Cavallazzi, A., Ferrari, A.U., Pedotti, A., Mancia, G.: Evaluation of baroreceptor reflex by blood pressure monitoring in unanesthetized cats. Am. J. Phys. 254, H377–H383 (1988)
Laude, D., Elghozi, J.L., Girard, A., Bellard, E., Bouhaddi, M., Castiglioni, P., et al.: Comparison of various techniques used to estimate spontaneous baroreflex sensitivity (the EuroBaVar study). Am. J. Phys. Regul. Integr. Comp. Phys. 286, R226–R231 (2004)
Schulz, S., Adochiei, F.C., Edu, I.R., Schroeder, R., Costin, H., Bar, K.J., et al.: Cardiovascular and cardiorespiratory coupling analyses: a review. Philos. Trans. A Math. Phys. Eng. Sci. 371, 20120191 (2013)
Porta, A., Marchi, A., Bari, V., Heusser, K., Tank, J., Jordan, J., et al.: Conditional symbolic analysis detects nonlinear influences of respiration on cardiovascular control in humans. Philos. Trans. A Math. Phys. Eng. Sci. 373, 20140096 (2015)
Bari, V., Marchi, A., De Maria, B., Rossato, G., Nollo, G., Faes, L., et al.: Nonlinear effects of respiration on the crosstalk between cardiovascular and cerebrovascular control systems. Philos. Trans. A Math. Phys. Eng. Sci. 374, 20150179 (2016)
Wessel, N., Suhrbier, A., Riedl, M., Marwan, N., Malberg, H., Bretthauer, G., et al.: Detection of time-delayed interactions in biosignals using symbolic coupling traces. EPL. 87, 10004 (2009)
Suhrbier, A., Riedl, M., Malberg, H., Penzel, T., Bretthauer, G., Kurths, J., et al.: Cardiovascular regulation during sleep quantified by symbolic coupling traces. Chaos. 20, 045124 (2010)
Schulz, S., Voss, A.: Cardiovascular and cardiorespiratory coupling analysis—State of the art and future perspectives, In: 2014 8th Conference of the European Study Group on Cardiovascular Oscillations (ESGCO), Trento, pp. 25–26. (2014).
Mourot, L., Bouhaddi, M., Perrey, S., Rouillon, J.D., Regnard, J.: Quantitative Poincare plot analysis of heart rate variability: effect of endurance training. Eur. J. Appl. Physiol. 91, 79–87 (2004)
Stein, P.K., Domitrovich, P.P., Huikuri, H.V., Kleiger, R.E.: Traditional and nonlinear heart rate variability are each independently associated with mortality after myocardial infarction. J. Cardiovasc. Electrophysiol. 16, 13–20 (2005)
T. Mäkikallio, Analysis of heart rate dynamics by methods derived from nonlinear mathematics: clinical applicability and prognostic significance: Oulun Yliopisto, 1998.
Voss, A., Kurths, J., Kleiner, H.J., Witt, A., Saparin, P., Dietz, R., et al.: New methods for the detection of high risk patients in cardiology. Biomed. Tech. (Berl). 39, 134–143 (1994)
Seeck, A., Baumert, M., Fischer, C., Khandoker, A., Faber, R., Voss, A.: Advanced Poincare plot analysis differentiates between hypertensive pregnancy disorders. Physiol. Meas. 32, 1611–1622 (2011)
Fischer, C., Voss, A.: Three-dimensional segmented Poincare plot analyses SPPA3 investigates cardiovascular and cardiorespiratory couplings in hypertensive pregnancy disorders. Front. Bioeng. Biotechnol. 2, 51 (2014)
Karmakar, C.K., Khandoker, A.H., Gubbi, J., Palaniswami, M.: Complex correlation measure: a novel descriptor for Poincare plot. Biomed. Eng. Online. 8, 17 (2009)
Lerma, C., Infante, O., Perez-Grovas, H., Jose, M.V.: Poincare plot indexes of heart rate variability capture dynamic adaptations after haemodialysis in chronic renal failure patients. Clin. Physiol. Funct. Imaging. 23, 72–80 (2003)
Li, M., Vitányi, P.M.B.: An introduction to kolmogorov complexity and its applications. Springer Publishing Company, Inc., Heidelberg (1997)
Baumert, M., Baier, V., Voss, A., Brechtel, L., Haueisen, J.: Estimating the complexity of heart rate fluctuations–an approach based on compression entropy. Fluct. Noise Lett. 5, L557–L563 (Dec 2005)
Truebner, S., Cygankiewicz, I., Schroeder, R., Baumert, M., Vallverdu, M., Caminal, P., et al.: Compression entropy contributes to risk stratification in patients with cardiomyopathy. Biomed. Tech. (Berl). 51, 77–82 (2006)
Costa, M., Goldberger, A.L., Peng, C.K.: Multiscale entropy analysis of complex physiologic time series. Phys. Rev. Lett. 89, 068102 (2002)
Schumann, A., Schulz, S., Voss, A., Scharbrodt, S., Baumert, M., Bär, K.-J.: Baroreflex coupling assessed by cross-compression entropy. Front. Physiol. 8, 282 (2017)
Granger, C.W.J.: Investigating causal relations by econometric models and cross-spectral methods. Econometrica. 37, 424–438 (1969)
Novak, V., Novak, P., de Champlain, J., Le Blanc, A.R., Martin, R., Nadeau, R.: Influence of respiration on heart rate and blood pressure fluctuations. J. Appl. Physiol. (1985). 74, 617–626 (1993)
Schulz, S., Bär, K.J., Voss, A.: Respiratory variability and cardiorespiratory coupling analyses in patients suffering from schizophrenia and their healthy first-degree relatives. Biomed. Tech. (Berl). 57(Suppl. 1), 1044 (2012)
Bär, K.J., Rachow, T., Schulz, S., Bassarab, K., Haufe, S., Berger, S., et al.: The phrenic component of acute schizophrenia--a name and its physiological reality. PLoS One. 7, e33459 (2012)
Voss, A., Schulz, S., Schroeder, R., Baumert, M., Caminal, P.: Methods derived from nonlinear dynamics for analysing heart rate variability. Philos. Trans. A Math. Phys. Eng. Sci. 367, 277–296 (2009)
Voss, A., Schulz, S., Schroder, R.: Analysis of cardiovascular oscillations using nonlinear dynamics methods for an enhanced diagnosis of heart and neurological diseases and for risk stratification. In: E-Health and Bioengineering Conference (EHB), vol. 2011, pp. 1–6 (2011)
Peupelmann, J., Boettger, M.K., Ruhland, C., Berger, S., Ramachandraiah, C.T., Yeragani, V.K., et al.: Cardio-respiratory coupling indicates suppression of vagal activity in acute schizophrenia. Schizophr. Res. 112, 153–157 (2009)
Schulz, S., Bar, K.J., Voss, A.: Respiratory variability and cardiorespiratory coupling analyses in patients suffering from schizophrenia and their healthy first-degree relatives. Biomed. Tech. (Berl). 57, 1044 (2012)
Homma, I., Masaoka, Y.: Breathing rhythms and emotions. Exp. Physiol. 93, 1011–1021 (2008)
Williams, L.M., Das, P., Harris, A.W., Liddell, B.B., Brammer, M.J., Olivieri, G., et al.: Dysregulation of arousal and amygdala-prefrontal systems in paranoid schizophrenia. Am. J. Psychiatry. 161, 480–489 (2004)
Boiten, F.A., Frijda, N.H., Wientjes, C.J.: Emotions and respiratory patterns: review and critical analysis. Int. J. Psychophysiol. 17, 103–128 (1994)
Weiden, P.J., Weiden, M.: Schizophrenia and respiratory symptoms: a serious, but overlooked, comorbidity. CNS Spectr. 15, 10–13 (2010)
Goodwin, R., Lyons, J.S., McNally, R.J.: Panic attacks in schizophrenia. Schizophr. Res. 58, 213–220 (Dec 1 2002)
Buckley, P.F., Miller, B.J., Lehrer, D.S., Castle, D.J.: Psychiatric comorbidities and schizophrenia. Schizophr. Bull. 35, 383–402 (2009)
Porta, A., Di Rienzo, M., Wessel, N., Kurths, J.: Addressing the complexity of cardiovascular regulation. Philos. Transact. A Math. Phys. Eng. Sci. 367, 1215–1218 (2009)
Voss, A., Seeck, A., Israel, A.K., Bar, K.J.: Enhanced spectral analysis of blood flow during post-occlusive reactive hyperaemia test in different tissue depths. Auton. Neurosci. 178, 15–23 (2013)
Voss, A., Goernig, M., Schroeder, R., Truebner, S., Schirdewan, A., Figulla, H.R.: Blood pressure variability as sign of autonomic imbalance in patients with idiopathic dilated cardiomyopathy. Pacing Clin. Electrophysiol. 35, 471–479 (2012)
Glass, L.: Chaos and heart rate variability. J. Cardiovasc. Electrophysiol. 10, 1358–1360 (1999)
Porta, A., Castiglioni, P., Di Rienzo, M., Bari, V., Bassani, T., Marchi, A., et al.: Short-term complexity indexes of heart period and systolic arterial pressure variabilities provide complementary information. J. Appl. Physiol. 113, 1810–1820 (2012)
Porta, A., Castiglioni, P., Di Rienzo, M., Bassani, T., Bari, V., Faes, L., et al.: Cardiovascular control and time domain Granger causality: insights from selective autonomic blockade. Philos. Trans. A Math. Phys. Eng. Sci. 371, 20120161 (2013)
Baccala, L.A., de Brito, C.S., Takahashi, D.Y., Sameshima, K.: Unified asymptotic theory for all partial directed coherence forms. Philos. Trans. A Math. Phys. Eng. Sci. 371, 20120158 (2013)
Blinowska, K.J., Kaminski, M., Brzezicka, A., Kaminski, J.: Application of directed transfer function and network formalism for the assessment of functional connectivity in working memory task. Philos. Trans. A Math. Phys. Eng. Sci. 371, 20110614 (2013)
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Schulz, S., Voss, A. (2017). Symbolic Dynamics, Poincaré Plot Analysis and Compression Entropy Estimate Complexity in Biological Time Series. In: Barbieri, R., Scilingo, E., Valenza, G. (eds) Complexity and Nonlinearity in Cardiovascular Signals. Springer, Cham. https://doi.org/10.1007/978-3-319-58709-7_2
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