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Gastro-Intestinal Failure

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Critical Care Nutrition Therapy for Non-nutritionists

Abstract

This chapter summarizes different aspects of gastrointestinal (GI) dysfunction in critically ill patients. Daily evaluation of the abdomen and monitoring of the amount and the aspect of faeces and lost GI secretions are the mainstay of assessment of GI (dys)function; no single reliable test is available. Knowledge on pathophysiology is needed to integrate different aspects, often including information obtained during surgery and/or dynamics of intra-abdominal pressure. Low-dose early enteral nutrition (EN) should be considered in most cases despite present/suspected GI dysfunction, whereas a cautious challenge of EN tolerance helps further evaluation of GI function. A practical algorithm including reasons to delay EN is presented.

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References

  1. Reintam Blaser A, Malbrain ML, Starkopf J, Fruhwald S, Jakob SM, De Waele J, Braun JP, Poeze M, Spies C. Gastrointestinal function in intensive care patients: terminology, definitions and management. Recommendations of the ESICM Working Group on Abdominal Problems. Intensive Care Med. 2012;38(3):384–94.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Pironi L, Arends J, Baxter J, Bozzetti F, Peláez RB, Cuerda C, Forbes A, Gabe S, Gillanders L, Holst M, Jeppesen PB, Joly F, Kelly D, Klek S, Irtun Ø, Olde Damink SW, Panisic M, Rasmussen HH, Staun M, Szczepanek K, Van Gossum A, Wanten G, Schneider SM, Shaffer J, Home Artificial Nutrition & Chronic Intestinal Failure; Acute Intestinal Failure Special Interest Groups of ESPEN. ESPEN endorsed recommendations. Definition and classification of intestinal failure in adults. Clin Nutr. 2015;34(2):171–80.

    Article  PubMed  Google Scholar 

  3. Klek S, Forbes A, Gabe S, Holst M, Wanten G, Irtun Ø, Damink SO, Panisic-Sekeljic M, Pelaez RB, Pironi L, Reintam Blaser A, Rasmussen HH, Schneider SM, Thibault R, Visschers RG, Shaffer J. Management of acute intestinal failure: a position paper from the European Society for Clinical Nutrition and Metabolism (ESPEN) Special Interest Group. Clin Nutr. 2016;35(6):1209–18.

    Article  PubMed  Google Scholar 

  4. Reintam Blaser A, Jakob SM, Starkopf J. Gastrointestinal failure in the ICU. Curr Opin Crit Care. 2016;22(2):128–41.

    PubMed  Google Scholar 

  5. Hamada SR, Garcon P, Ronot M, Kerever S, Paugam-Burtz C, Mantz J. Ultrasound assessment of gastric volume in critically ill patients. Intensive Care Med. 2014;40(7):965–72.

    Article  CAS  PubMed  Google Scholar 

  6. Reignier J, Mercier E, Le Gouge A, Boulain T, Desachy A, Bellec F, Clavel M, Frat JP, Plantefeve G, Quenot JP, Lascarrou JB. Clinical Research in Intensive Care and Sepsis (CRICS) Group. Effect of not monitoring residual gastric volume on risk of ventilator-associated pneumonia in adults receiving mechanical ventilation and early enteral feeding: a randomized controlled trial. JAMA. 2013;309(3):249–56.

    Article  CAS  PubMed  Google Scholar 

  7. Reintam Blaser A, Starkopf J, Alhazzani W, Berger MM, Casaer MP, Deane AM, Fruhwald S, Hiesmayr M, Ichai C, Jakob SM, Loudet CI, Malbrain ML, Montejo González JC, Paugam-Burtz C, Poeze M, Preiser JC, Singer P, van Zanten AR, De Waele J, Wendon J, Wernerman J, Whitehouse T, Wilmer A, Oudemans-van Straaten HM. ESICM Working Group on Gastrointestinal Function. Early enteral nutrition in critically ill patients: ESICM clinical practice guidelines. Intensive Care Med. 2017;43(3):380–98.

    Article  PubMed  PubMed Central  Google Scholar 

  8. van der Spoel JI, Oudemans-van Straaten HM, Kuiper MA, van Roon EN, Zandstra DF, van der Voort PH. Laxation of critically ill patients with lactulose or polyethylene glycol: a two-center randomized, double-blind, placebo-controlled trial. Crit Care Med. 2007;35(12):2726–31.

    PubMed  Google Scholar 

  9. van der Spoel JI, Schultz MJ, van der Voort PH, de Jonge E. Influence of severity of illness, medication and selective decontamination on defecation. Intensive Care Med. 2006;32(6):875–80.

    Article  PubMed  Google Scholar 

  10. Saunders MD. Acute colonic pseudo-obstruction. Gastrointest Endosc Clin N Am. 2007;17(2):341–60.

    Article  PubMed  Google Scholar 

  11. van der Spoel JI, Oudemans-van Straaten HM, Stoutenbeek CP, Bosman RJ, Zandstra DF. Neostigmine resolves critical illness-related colonic ileus in intensive care patients with multiple organ failure—a prospective, double-blind, placebo-controlled trial. Intensive Care Med. 2001;27(5):822–7.

    Article  PubMed  Google Scholar 

  12. Thibault R, Graf S, Clerc A, Delieuvin N, Heidegger CP, Pichard C. Diarrhoea in the ICU: respective contribution of feeding and antibiotics. Crit Care. 2013;17:R153.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Reintam Blaser A, Deane AM, Fruhwald S. Diarrhoea in the critically ill. Curr Opin Crit Care. 2015;21(2):142–53.

    Article  PubMed  Google Scholar 

  14. Kamarul Zaman M, Chin KF, Rai V, Majid HA. Fiber and prebiotic supplementation in enteral nutrition: a systematic review and meta-analysis. World J Gastroenterol. 2015;21(17):5372–81.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Becquemin JP1, Majewski M, Fermani N, Marzelle J, Desgrandes P, Allaire E, Roudot-Thoraval F. Colon ischemia following abdominal aortic aneurysm repair in the era of endovascular abdominal aortic repair. J Vasc Surg. 2008;47(2):258–63; discussion 263.

    Google Scholar 

  16. Nessim C, Sidéris L, Turcotte S, Vafiadis P, Lapostole AC, Simard S, Koch P, Fortier LP, Dubé P. The effect of fluid overload in the presence of an epidural on the strength of colonic anastomoses. J Surg Res. 2013;183(2):567–73.

    Article  PubMed  Google Scholar 

  17. Kirkpatrick AW, Roberts DJ, De Waele J, Jaeschke R, Malbrain ML, De Keulenaer B, Duchesne J, Bjorck M, Leppaniemi A, Ejike JC, Sugrue M, Cheatham M, Ivatury R, Ball CG, Reintam Blaser A, Regli A, Balogh ZJ, D’Amours S, Debergh D, Kaplan M, Kimball E, Olvera C, Pediatric Guidelines Sub-Committee for the World Society of the Abdominal Compartment Syndrome. Intra-abdominal hypertension and the abdominal compartment syndrome: updated consensus definitions and clinical practice guidelines from the World Society of the Abdominal Compartment Syndrome. Intensive Care Med. 2013;39(7):1190–206.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Bejarano N, Navarro S, Rebasa P, García-Esquirol O, Hermoso J. Intra-abdominal pressure as a prognostic factor for tolerance of enteral nutrition in critical patients. JPEN J Parenter Enteral Nutr. 2013;37(3):352–60.

    Article  PubMed  Google Scholar 

  19. Perinel J, Mariette C, Dousset B, et al. Early enteral versus total parenteral nutrition in patients undergoing pancreaticoduodenectomy: a randomized multicenter controlled trial (Nutri-DPC). Ann Surg. 2016;264:731–7.

    Article  PubMed  Google Scholar 

  20. Cereda E, Caccialanza R, Pedrolli C. Feeding after pancreaticoduodenectomy: enteral, or parenteral, that is the question. J Thorac Dis. 2016;8(11):E1478–80.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Karanika S, Paudel S, Zervou FN, Grigoras C, Zacharioudakis IM, Mylonakis E. Prevalence and clinical outcomes of Clostridium difficile infection in the intensive care unit: a systematic review and meta-analysis. Open Forum Infect Dis. 2015;3(1):ofv186. eCollection 2016.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Rodrigues FG, Dasilva G, Wexner SD. Neutropenic enterocolitis. World J Gastroenterol. 2017;23(1):42–7.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Lebon D, Biard L, Buyse S, Schnell D, Lengliné E, Roussel C, Gornet JM, Munoz-Bongrand N, Quéro L, Resche-Rigon M, Azoulay E, Canet E. Gastrointestinal emergencies in critically ill cancer patients. J Crit Care. 2017;40:69–75.

    Article  PubMed  Google Scholar 

  24. Ferrie S, Graham C, Hoyle M. Pancreatic enzyme supplementation for patients receiving enteral feeds. Nutr Clin Pract. 2011;26(3):349–51.

    Article  PubMed  Google Scholar 

  25. Heidegger CP, Berger MM, Graf S, Zingg W, Darmon P, Costanza MC, Thibault R, Pichard C. Optimisation of energy provision with supplemental parenteral nutrition in critically ill patients: a randomised controlled clinical trial. Lancet. 2013;381(9864):385–93.

    Article  PubMed  Google Scholar 

  26. Casaer MP, Mesotten D, Hermans G, Wouters PJ, Schetz M, Meyfroidt G, Van Cromphaut S, Ingels C, Meersseman P, Muller J, Vlasselaers D, Debaveye Y, Desmet L, Dubois J, Van Assche A, Vanderheyden S, Wilmer A, Van den Berghe G. Early versus late parenteral nutrition in critically ill adults. N Engl J Med. 2011;365(6):506–17.

    Article  CAS  PubMed  Google Scholar 

  27. Doig GS, Simpson F, Sweetman EA, Finfer SR, Cooper DJ, Heighes PT, et al. Early parenteral nutrition in critically ill patients with short-term relative contraindications to early enteral nutrition: a randomized controlled trial. JAMA. 2013;309:2130–8.

    Article  CAS  PubMed  Google Scholar 

  28. Doig GS, Simpson F, Heighes PT, Bellomo R, Chesher D, Caterson ID, Reade MC, Harrigan PW. Refeeding Syndrome Trial Investigators Group. Restricted versus continued standard caloric intake during the management of refeeding syndrome in critically ill adults: a randomised, parallel-group, multicentre, single-blind controlled trial. Lancet Respir Med. 2015;3(12):943–52.

    Article  PubMed  Google Scholar 

  29. National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network, Rice TW, Wheeler AP, Thompson BT, Steingrub J, Hite RD, Moss M, Morris A, Dong N, Rock P. Initial trophic vs full enteral feeding in patients with acute lung injury: the EDEN randomized trial. JAMA. 2012;307(8):795–803.

    Article  Google Scholar 

  30. Arabi YM, Aldawood AS, Haddad SH, Al-Dorzi HM, Tamim HM, Jones G, Mehta S, McIntyre L, Solaiman O, Sakkijha MH, Sadat M, Afesh L, Permit Trial Group. Permissive underfeeding or standard enteral feeding in critically ill adults. N Engl J Med. 2015;372(25):2398–408.

    Article  CAS  PubMed  Google Scholar 

  31. Weijs PJ, Looijaard WG, Beishuizen A, Girbes AR, Oudemans-van Straaten HM. Early high protein intake is associated with low mortality and energy overfeeding with high mortality in non-septic mechanically ventilated critically ill patients. Crit Care. 2014;18(6):701.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Zusman O, Theilla M, Cohen J, Kagan I, Bendavid I, Singer P. Resting energy expenditure, calorie and protein consumption in critically ill patients: a retrospective cohort study. Crit Care. 2016;20(1):367.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Thibault R, Picot D. Chyme reinfusion or enteroclysis in nutrition of patients with temporary double enterostomy or enterocutaneous fistula. Curr Opin Clin Nutr Metab Care. 2016;19(5):382–87.

    Google Scholar 

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Correspondence to Annika Reintam-Blaser .

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Reintam-Blaser, A., Oudemans-van Straaten, H.M. (2018). Gastro-Intestinal Failure. In: Berger, M. (eds) Critical Care Nutrition Therapy for Non-nutritionists. Springer, Cham. https://doi.org/10.1007/978-3-319-58652-6_4

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  • DOI: https://doi.org/10.1007/978-3-319-58652-6_4

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