Advertisement

Metal Allergy pp 523-531 | Cite as

Metal Allergy and Contact Urticaria

  • Niels H. Bennike
  • Majken H. Foss-Skiftesvik
Chapter

Abstract

Despite the frequent and widespread exposure to metals, few cases of contact urticaria caused by metals have been reported. The majority of cases are found among persons with occupational exposure to metals, especially in an industrial setting. Often, the symptoms of contact urticaria do not occur until after several years of exposure. The majority of cases are caused by exposure to nickel, but also aluminum, chromium, cobalt, and the metals belonging to the platinum group elements have been reported to induce urticarial reactions. All metals involved in contact urticaria belong to the transitional metal group and are primarily allergenic as salts and not in their metallic form. Although the mechanism behind metal-induced contact urticaria is unclear, most published cases report a relevant positive skin prick test, indicating involvement of an IgE-mediated mechanism or nonspecific release of histamine.

References

  1. 1.
    Thyssen JP, Menné T. Metal allergy—a review on exposures, penetration, genetics, prevalence, and clinical implications. Chem Res Toxicol. 2010;23:309–18.CrossRefGoogle Scholar
  2. 2.
    Wakelin SH. Contact Urticaria syndrome. Clin Exp Dermatol. 2001;26:132–6.CrossRefGoogle Scholar
  3. 3.
    Giménez-Arnau A, Maurer M, De La Cuadra J, Maibach H. Immediate contact skin reactions, an update of Contact Urticaria, Contact Urticaria Syndrome and Protein Contact Dermatitis—a Never Ending Story. Eur J Dermatology. 2010;20:552–62.Google Scholar
  4. 4.
    Maibach H, Johnson H. Contact Urticaria syndrome. Arch Dermatol. 1975;111:726–30.CrossRefGoogle Scholar
  5. 5.
    Bergman A, Svedberg U, Nilsson E. Contact urticaria with anaphylactic reactions caused by occupational exposure to iridium salt. Contact Dermatitis. 1995;32:14–7.CrossRefGoogle Scholar
  6. 6.
    Krecisz B, Kiec-Swierczynska M, Krawczyk P, et al. Cobalt-induced anaphylaxis, contact urticaria, and delayed allergy in a ceramics decorator. Contact Dermatitis. 2009;60:173–4.CrossRefGoogle Scholar
  7. 7.
    Williams JDL, Lee AYL, Matheson MC, et al. Occupational contact urticaria: Australian data. Br J Dermatol. 2008;159:125–31.CrossRefGoogle Scholar
  8. 8.
    Kligman AM. The spectrum of contact urticaria. Wheals, erythema, and pruritus. Dermatol Clin. 1990;8:57–60.PubMedGoogle Scholar
  9. 9.
    Jasmin G. Anaphylactoid edema induced in rats by nickel and cobalt salts. Proc Soc Exp Biol Med. 1974;147:289–92.CrossRefGoogle Scholar
  10. 10.
    Estlander T, Kanerva L, Tupasela O, et al. Immediate and delayed allergy to nickel with contact urticaria, rhinitis, asthma and contact dermatitis. Clin Exp Allergy. 1993;23:306–10.CrossRefGoogle Scholar
  11. 11.
    Büyüköztürk S, Gelincik A, Ünal D, et al. Oral nickel exposure may induce type I hypersensitivity reaction in nickel-sensitized subjects. Int Immunopharmacol. 2015;26:92–6.CrossRefGoogle Scholar
  12. 12.
    Osmundsen PE. Contact urticaria from nickel and plastic additives. Contact Dermatitis. 1980;6:452–4.CrossRefGoogle Scholar
  13. 13.
    Malo JL, Cartier A, Doepner M, et al. Occupational asthma caused by nickel sulfate. J Allergy Clin Immunol. 1982;69:55–9.CrossRefGoogle Scholar
  14. 14.
    Tosti A, Melino M, Labanca M, Ragazzi R. Immediate hypersensitivity to nickel. Contact Dermatitis. 1986;15:95.CrossRefGoogle Scholar
  15. 15.
    Valsecchi R, Cainelli T. Contact urticaria from nickel. Contact Dermatitis. 1987;17:187.CrossRefGoogle Scholar
  16. 16.
    Walsh ML, Smith VH, King CM. Type 1 and type IV hypersensitivity to nickel. Australas J Dermatol. 2010;51:285–6.CrossRefGoogle Scholar
  17. 17.
    Bregnbak D, Johansen JD, Jellesen MS, et al. Chromium allergy and dermatitis: prevalence and main findings. Contact Dermatitis. 2015;73:261–80.CrossRefGoogle Scholar
  18. 18.
    Zachariae CO, Agner T, Menné T. Chromium allergy in consecutive patients in a country where ferrous sulfate has been added to cement since 1981. Contact Dermatitis. 1996;35:83–5.CrossRefGoogle Scholar
  19. 19.
    Aslan A. Determination of heavy metal toxicity of finished leather solid waste. Bull Environ Contam Toxicol. 2009;82:633–8.CrossRefGoogle Scholar
  20. 20.
    Pizzino J. Letter to the editor: possible chromate-associated urticaria. J Occup Med. 1993;35:96–7.CrossRefGoogle Scholar
  21. 21.
    Lidén C, Bruze M, Thyssen JP, Menné T. Chapter 35—Metals. In: Johansen JD, Lepoittevin JP, Frosch PJ, editors. Contact dermat. 5th ed. Berlin, Heidelberg: Springer; 2011. p. 643–79.CrossRefGoogle Scholar
  22. 22.
    Smith JD, Odom RB, Maibach HI. Contact Urticaria from cobalt chloride. Arch Dermatol. 1975;111:1610–1.CrossRefGoogle Scholar
  23. 23.
    Bagnato GF, De Pasquale R, Giacobbe O, et al. Urticaria in a tattooed patient. Allergol Immunopathol (Madr). 1999;27:32–3.Google Scholar
  24. 24.
    Siemund I, Zimerson E, Hindsén M, Bruze M. Establishing aluminium contact allergy. Contact Dermatitis. 2012;67:162–70.CrossRefGoogle Scholar
  25. 25.
    Bergfors E, Hermansson G, Nyström Kronander U, et al. How common are long-lasting, intensely itching vaccination granulomas and contact allergy to aluminium induced by currently used pediatric vaccines? A prospective cohort study. Eur J Pediatr. 2014;173:1297–307.CrossRefGoogle Scholar
  26. 26.
    Helgesen AL, Austad J. Contact urticaria from aluminium and nickel in the same patient. Contact Dermatitis. 1997;37:303–4.CrossRefGoogle Scholar
  27. 27.
    Santucci B, Valenzano C, de Rocco M, Cristaudo A. Platinum in the environment: frequency of reactions to platinum-group elements in patients with dermatitis and urticaria. Contact Dermatitis. 2000;43:333–8.CrossRefGoogle Scholar
  28. 28.
    Cristaudo A, Sera F, Severino V, et al. Occupational hypersensitivity to metal salts, including platinum, in the secondary industry. Allergy Eur J Allergy Clin Immunol. 2005;60:159–64.CrossRefGoogle Scholar
  29. 29.
    Guy RH, Hostynek JJ, Hinz RS. Chapter 29—Platinum. In:Metals and the skin: topical effects and systemic absorption. Ann Arbor, MI: CRC Press, ProQuest ebrary; 2016.Google Scholar
  30. 30.
    Cromwell O, Pepys J, Parish WE, Hughes EG. Specific IgE antibodies to platinum salts in sensitized workers. Clin Allergy. 1979;9:109–17.CrossRefGoogle Scholar
  31. 31.
    Park H, Lee J, Kim S, et al. A new practical desensitization protocol for Oxaliplatin-induced immediate hypersensitivity reactions: a necessary and useful approach. J Investig Allergol Clin Immunol. 2016;26:168–76.CrossRefGoogle Scholar
  32. 32.
    Schena D, Barba A, Costa G. Occupational contact urticaria due to cisplatin. Contact Dermatitis. 1996;34:220–1.CrossRefGoogle Scholar
  33. 33.
    Stingeni L, Brunelli L, Lisi P. Contact sensitivity to rhodium and iridium in consecutively patch tested subjects. Contact Dermatitis. 2004;51:316–7.CrossRefGoogle Scholar
  34. 34.
    Faurschou A, Menné T, Johansen JD, Thyssen JP. Metal allergen of the 21st century - a review on exposure, epidemiology and clinical manifestations of palladium allergy. Contact Dermatitis. 2011;64:185–95.CrossRefGoogle Scholar
  35. 35.
    Pesonen M, Airaksinen L, Voutilainen R, et al. Occupational contact urticaria and rhinitis caused by immediate allergy to palladium salts. Contact Dermatitis. 2014;71:176–7.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Dermatology and AllergyCopenhagen University Hospital Herlev-GentofteHellerupDenmark

Personalised recommendations