Metal Allergy pp 333-336 | Cite as

Metal Allergy: Aluminium

  • Monica Hindsén


Aluminium is one of the most abundant metals in the earth’s crust, and aluminium compounds are widely used. Aluminium is considered to be a weak allergen, but contact allergy to aluminium has been more frequently reported in recent years. The most important routes of sensitization to aluminium are aluminium-containing vaccines, hyposensitization with aluminium-adsorbed extracts and contact with aluminium in antiperspirants and other skin products. In this chapter, the literature on aluminium contact sensitization, patch testing and management considerations is reviewed.


  1. 1.
    Lidén C, Bruze M, Menné T. Metals. In: Menné T, Lepoittevin J-P, Frosch PJ, editors. Contact dermatitis. 4th ed. NewYork: Springer; 2006. p. 537–68.CrossRefGoogle Scholar
  2. 2.
    Bergfors E, Trollfors B. Sixty-four children with persistent itching nodules and contact allergy to aluminium after vaccination with aluminium—absorbed vaccines-prognosis and outcome after booster vacccination. Eur J Pediatr. 2013;172(2):171–7.CrossRefGoogle Scholar
  3. 3.
    Siemund I, Zimerson E, Hindsén M, Bruze M. Establishing aluminium contact allergy. Contact Dermatitis. 2012;67:162–70.CrossRefGoogle Scholar
  4. 4.
    Clemmensen O, Knudsen HE. Contact sensitivity to aluminium in a patient hyposensitized with aluminium precipitated grass pollen. Contact Dermatitis. 1980;6:305–8.CrossRefGoogle Scholar
  5. 5.
    Bruze M, Lundh K, Gruvberger B, Hindsén M. Aluminium chloride hexahydrat is insufficent to trace contact allergy to aluminium. Contact Dermatitis. 2008;59:183–4.CrossRefGoogle Scholar
  6. 6.
    Frost L, Johansen P, Pedersen S, Veien N, Ostergaard PA, Nielsen MH. Persistent subcutaneous nodules in children hyposensitized with aluminium-containing allergen extracts. Allergy. 1985;40:368–72.CrossRefGoogle Scholar
  7. 7.
    Lopez S, Pelaez A, Navorro A, Montesinos E, Morales C, Carda C. Aluminium allergy in patient hyposensitized with aluminium-precipitated antigen extracts. Contact Dermatitis. 1994;31:37–40.CrossRefGoogle Scholar
  8. 8.
    Hindsén M. Contact allergy to aluminium in patients hyposensitized with aluminium-containing hyposensitizing extracts. Contact Dermatitis. 2005;53:301–2.CrossRefGoogle Scholar
  9. 9.
    Netterlid E, Hindsén M, Björk J, Ekqvist S, Guner N, Henriksson KÅ, Bruze M. There is an association between contact allergy to aluminium and persistent sucutaneous nodules in children undergoing hypersensitization therapy. Contact Dermatitis. 2009;60:41–9.CrossRefGoogle Scholar
  10. 10.
    Netterlid E, Hindsén M, Siemund I, Björk J, Werner S, Jacobsson H, Guner N, Bruze M. Does allergen-specific immunotherapy induce contact allergy to aluminium? Acta Derm Venereol. 2013;93:50–6.CrossRefGoogle Scholar
  11. 11.
    Bergfors E, Trollfors B, Inerot A. Uexpected high incidence of persistent iching nodules and delayed hypersensitivityto aluminiumin children after the use of absorbed vaccines from a single manufacturen. Vaccine. 2003;22:64–9.CrossRefGoogle Scholar
  12. 12.
    Siemund I, Hindsén M, Zimerson E, Bruze M. Individual variation in aluminium patch test reactivity. Abstract ESCD Manchester. 2016.Google Scholar
  13. 13.
    Lidholm AG, Bergfors E, Inerot A, Blomgren U, Gillstedt M, Trollfors B. Unexpected loss of contact allergy to aluminium induced by vaccine. Contact Dermatitis. 2013;68:286–92.CrossRefGoogle Scholar
  14. 14.
    Netterlid E, Bruze M, Hindsén M, Isaksson M, Olin P. Persisting itching nodules after the fourth dose of diphtheria-tetanus toxoid vaccines without evidence of delayed hypersensitivity to aluminium. Vaccine. 2004;22:3698–706.CrossRefGoogle Scholar
  15. 15.
    Brodbaker E, Pratt M. Contact sensitivity to aluminium. J Cutan Med Surg. 2009;13:226–9.CrossRefGoogle Scholar
  16. 16.
    Meding B, Augustsson A, Hansson C. Patch test reactions to aluminium. Contact Dermatitis. 1984;10:107.CrossRefGoogle Scholar
  17. 17.
    Garg S, Loghdey S, Gawkrodger DJ. Allergic contact dermatitis from aluminium in deodorants. Contact Dermatitis. 2010;62:57–8.CrossRefGoogle Scholar
  18. 18.
    O’Driscoll JB, Beck MB, Kesseler ME, Ford G. Contact sensitivity to aluminium acetate eardrops. Contact Dermatitis. 1991;24:156–7.CrossRefGoogle Scholar
  19. 19.
    Veien NK, Hattel T, Laurberg G. Systemic aggravated contact dermatitis caused by aluminium in toothpaste. Contact Dermatitis. 1993;28:199–200.CrossRefGoogle Scholar
  20. 20.
    McFadden N, Lyberg T, Hensten-Pettersen A. Aluminium-induced granulomas in tattoo. J Am Acad Dermatol. 1989;20:903–8.CrossRefGoogle Scholar
  21. 21.
    Peters T, Hani N, Kirchberg K, Gold H, Hunzelmann N, Scharffetter-Kochanek K. Occupational contact sensitivity to aluminium in a machine construction plant worker. Contact Dermatitis. 1998;39:322–3.CrossRefGoogle Scholar
  22. 22.
    Salik E, Lovik I, Andersen KE, Bygun A. Persistent skin reactions and aluminium hypersensitivity induced by childhood vaccines. Acta Derm Venereol. 2016;96:967–71.CrossRefGoogle Scholar
  23. 23.
    Bergfors E, Trollfors B, Inerot A, Gente Lidholm A. Contact allergy to aluminium induced by commonly used pediatric vaccines. Clin Transl Med. 2017;6:4.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Dermatology Lund University hospitalMalmöSweden

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