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Involvement of Chromogranin A and Its Derived Peptides to Fight Infections

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Chromogranins: from Cell Biology to Physiology and Biomedicine

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Abstract

In this chapter, after the presentation of the expression of Chromogranin A and its antimicrobial derived peptides in circulation, we report a clinical analysis for Vasostatin-I (VS-I) and the preparation of antimicrobial coating with Cateslytin (CTL). In a clinical multicenter analysis of VS-I in the plasma of critically ill patients (481 patients and 13 healthy staff), we have shown for the first time, that an increase in the VS-I concentration was present on admission in non-selected critically ill patients and that it was associated with poor outcome at day 28 after admission. By using a combination of VS-I, lactate and age values, our assessment of prognosis was better than taking the parameters alone. Concerning the preparation of antimicrobial biomaterial we decided to use polysaccharide multilayer film based on CTL functionalized hyaluronic acid as polyanion and chitosan as polycation, (HA-CTL-C/CHI), with the aim of designing a self-defensive coating against both bacteria (Staphylococcus aureus) and yeast (Candida albicans). The ability of S. aureus and Candida species to degrade HA, by producing hyaluronidase, allows the active peptide to be released from film only in the presence of the pathogens. We have demonstrated the antimicrobial activities of HA-CTL in solution and HA-CTL-C/CHI films against S. aureus and C. albicans. We have shown the penetration of the fluorescently labeled HA FITC -CTL-C into the cell membrane of C. albicans and the cytotoxicity of HA-CTL-C/CHI films was tested through human gingival fibroblasts (HGFs) viability.

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Authors and Affiliations

  1. Inserm U1121, Université de Strasbourg, FMTS, Faculté de Chirurgie Dentaire Hôpital Civil, Porte de l’hôpital, 67000, Strasbourg, France

    Marie-Hélène Metz-Boutigue

  2. Inserm U1121, Université de Strasbourg, FMTS, Service de Réanimation Médicale, Hôpital Hautepierre, Avenue Molière, 67000, Strasbourg, France

    Francis Schneider

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  1. Marie-Hélène Metz-Boutigue
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  2. Francis Schneider
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Correspondence to Marie-Hélène Metz-Boutigue .

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Editors and Affiliations

  1. Department of Biology, Ecology and Earth Sciences, University of Calabria, Arcavacata di Rende, Cosenza, Italy

    Tommaso Angelone

  2. Department of Biology, Ecology and Earth Sciences, University of Calabria, Arcavacata di Rende, Cosenza, Italy

    Maria Carmela Cerra

  3. Department of Biology, Ecology and Earth Science, University of Calabria, Arcavacata di Rende, Cosenza, Italy

    Bruno Tota

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Metz-Boutigue, MH., Schneider, F. (2017). Involvement of Chromogranin A and Its Derived Peptides to Fight Infections. In: Angelone, T., Cerra, M., Tota, B. (eds) Chromogranins: from Cell Biology to Physiology and Biomedicine. UNIPA Springer Series. Springer, Cham. https://doi.org/10.1007/978-3-319-58338-9_4

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