Abstract
Key Points
-
1.
Sialorrhea is a common condition affecting both children and adults with neuromuscular disorders including cerebral palsy, Parkinson’s disease, amyotrophic lateral sclerosis, and other neurodegenerative disorders.
-
2.
Sialorrhea is a highly distressing problem that can lead to significant psychological, social, and medical issues.
-
3.
A multidisciplinary approach involving speech therapy, neurology, otolaryngology, and others is advisable to help with the complex decision-making process.
-
4.
In most cases, noninvasive therapeutic modalities such as physiotherapy and systemic medication should be explored prior to more invasive therapies such as the injection of botulinum toxin and surgery.
-
5.
There is no consensus as to the best surgical procedure to treat sialorrhea. Procedure selection should be guided by patient characteristics including severity of drooling, presence of aspiration, and overall medical condition. It is imperative to give patients and their families clear expectations of treatment.
This is a preview of subscription content, log in via an institution.
References
Erasmus CE, Van Hulst K, Rotteveel LJ, et al. Drooling in cerebral palsy: hypersalivation or dysfunctional oral motor control? Dev Med Child Neurol. 2009;51:454–9.
Holsinger FC, Bui DT. Anatomy, function, and evaluation of the salivary glands. In: Myers EN, Ferris RL, editors. Salivary gland disorders. Berlin: Springer; 2007. p. 1–16.
Volonte MA, Porta M, Comi G. Clinical assessment of dysphagia in early phases of Parkinson’s disease. Neurol Sci. 2002;23(Suppl 2):S121–2.
Tahmassebi JF, Curzon MEJ. The cause of drooling in children with cerebral palsy—hypersalivation or swallowing defect? Int J Paediatr Dent. 2003;13:106–11.
Hamdy S, Aziz Q, Rothwell JC, Hobson A, Barlow J, Thompson DG. Cranial nerve modulation of human cortical swallowing motor pathways. Am J Physiol. 1997;272:G802–8.
van der Burg JJ, Jongerius PH, van Limbeek J, van Hulst K, Rotteveel JJ. Social interaction and self-esteem of children with cerebral palsy after treatment for severe drooling. Eur J Pediatr. 2006;165:37–41.
Van der Burg JJ, Jongerius PH, Van Hulst K, Van Limbeek J, Rotteveel JJ. Drooling in children with cerebral palsy: effect of salivary flow reduction on daily life and care. Dev Med Child Neurol. 2006;48:103–7.
Miranda-Rius J, Brunet-Llobet L, Lahor-Soler E, Farré M. Salivary secretory disorders, inducing drugs, and clinical management. Int J Med Sci. 2015;12:811–24.
Ekedahl C, Hallen O. Quantitative measurement of drooling. Acta Otolaryngol. 1973;75:464–9.
Sochaniwskyj AE. Drool quantification: noninvasive technique. Arch Phys Med Rehabil. 1982;63:605–7.
Reid SM, Johnson HM, Reddihough DS. The drooling impact scale: a measure of the impact of drooling in children with developmental disabilities. Dev Med Child Neurol. 2010;52:e23–8.
Reddihough D, Johnson H, Ferguson E. The role of a saliva control clinic in the management of drooling. J Paediatr Child Health. 1992;28:395–7.
Rapp D. Management of drooling. Dev Med Child Neurol. 1988;30:128–9.
van Hulst K, Lindeboom R, van der Burg J, Jongerius P. Accurate assessment of drooling severity with the 5-minute drooling quotient in children with developmental disabilities. Dev Med Child Neurol. 2012;54:1121–6.
Blasco PA. Management of drooling: 10 years after the consortium on drooling, 1990. Dev Med Child Neurol. 2002;44:778–81.
Thomas-Stonell N, Greenberg J. Three treatment approaches and clinical factors in the reduction of drooling. Dysphagia. 1988;3:73–8.
Heine RG, Catto-Smith AG, Reddihough DS. Effect of antireflux medication on salivary drooling in children with cerebral palsy. Dev Med Child Neurol. 1996;38:1030–6.
Camp-Bruno JA, Winsberg BG, Green-Parsons AR, Abrams JP. Efficacy of benztropine therapy for drooling. Dev Med Child Neurol. 1989;31:309–19.
Rashnoo P, Daniel SJ. Drooling quantification: correlation of different techniques. Int J Pediatr Otorhinolaryngol. 2015;79:1201–5.
Harris MM, Dignam PF. A non-surgical method of reducing drooling in cerebral-palsied children. Dev Med Child Neurol. 1980;22:293–9.
Arvedson JC, Brodsky L. Pediatric swallowing and feeding. San Diego: Singular Publishing Group; 1993.
Hyson HC, Johnson AM, Jog MS. Sublingual atropine for sialorrhea secondary to parkinsonism: a pilot study. Mov Disord. 2002;17:1318–20.
Comley C, Galletly C, Ash D. Use of atropine eye drops for clozapine induced hypersalivation. Aust N Z J Psychiatry. 2000;34:1033–4.
Mirakhur RK, Dundee JW. Comparison of the effects of atropine and glycopyrrolate on various end-organs. J R Soc Med. 1980;73:727–30.
Eiland LS. Glycopyrrolate for chronic drooling in children. Clin Ther. 2012;34:735–42.
Mier RJ, Bachrach SJ, Lakin RC, Barker T, Childs J, Moran M. Treatment of sialorrhea with glycopyrrolate: a double-blind, dose-ranging study. Arch Pediatr Adolesc Med. 2000;154:1214–8.
Zeller RS, Lee HM, Cavanaugh PF, Davidson J. Randomized phase III evaluation of the efficacy and safety of a novel glycopyrrolate oral solution for the management of chronic severe drooling in children with cerebral palsy or other neurologic conditions. Ther Clin Risk Manag. 2012;8:15–23.
Lim M, Mace A, Nouraei SA, Sandhu G. Botulinum toxin in the management of sialorrhoea: a systematic review. Clin Otolaryngol. 2006;31:267–72.
Lakraj AA, Moghimi N, Jabbari B. Sialorrhea: anatomy, pathophysiology and treatment with emphasis on the role of botulinum toxins. Toxins. 2013;5:1010–31.
Bushara KO. Sialorrhea in amyotrophic lateral sclerosis: a hypothesis of a new treatment—botulinum toxin a injections of the parotid glands. Med Hypotheses. 1997;48:337–9.
Petracca M, Guidubaldi A, Ricciardi L, et al. Botulinum toxin a and B in sialorrhea: long-term data and literature overview. Toxicon. 2015;107:129–40.
Daniel SJ. Multidisciplinary management of sialorrhea in children. Laryngoscope. 2012;122(Suppl 4):S67–8.
Suskind DL, Tilton A. Clinical study of botulinum—a toxin in the treatment of sialorrhea in children with cerebral palsy. Laryngoscope. 2002;112:73–81.
Jeung IS, Lee S, Kim HS, Yeo CK. Effect of botulinum toxin a injection into the salivary glands for sialorrhea in children with neurologic disorders. Ann Rehabil Med. 2012;36:340–6.
Khan WU, Campisi P, Nadarajah S, et al. Botulinum toxin a for treatment of sialorrhea in children: an effective, minimally invasive approach. Arch Otolaryngol Head Neck Surg. 2011;137:339–44.
Reed J, Mans CK, Brietzke SE. Surgical management of drooling: a meta-analysis. Arch Otolaryngol Head Neck Surg. 2009;135:924–31.
Wilkie TF. The problem of drooling in cerebral palsy: a surgical approach. Can J Surg. 1967;10:60–7.
Wilkie TF, Brody GS. The surgical treatment of drooling. A ten-year review. Plast Reconstr Surg. 1977;59:791–7.
Faggella RM, Jr., Osborn JM. Surgical correction of drool: a comparison of three groups of patients. Plast Reconstr Surg 1983; 72:478-483.
Becmeur F, Schneider A, Flaum V, Klipfel C, Pierrel C, Lacreuse I. Which surgery for drooling in patients with cerebral palsy? J Pediatr Surg. 2013;48:2171–4.
De M, Adair R, Golchin K, Cinnamond MJ. Outcomes of submandibular duct relocation: a 15-year experience. J Laryngol Otol. 2003;117:821–3.
Ekedahl C. Surgical treatment of drooling. Acta Otolaryngol. 1974;77:215–20.
Crysdale WS, White A. Submandibular duct relocation for drooling: a 10-year experience with 194 patients. Otolaryngol Head Neck Surg. 1989;101:87–92.
Greensmith AL, Johnstone BR, Reid SM, Hazard CJ, Johnson HM, Reddihough DS. Prospective analysis of the outcome of surgical management of drooling in the pediatric population: a 10-year experience. Plast Reconstr Surg. 2005;116:1233–42.
McAloney N, Kerawala CJ, Stassen LF. Management of drooling by transposition of the submandibular ducts and excision of the sublingual glands. J Ir Dent Assoc. 2005;51:126–31.
Hornibrook J, Cochrane N. Contemporary surgical management of severe sialorrhea in children. ISRN Pediatr. 2012;2012:364875.
Klem C, Mair EA. Four-duct ligation: a simple and effective treatment for chronic aspiration from sialorrhea. Arch Otolaryngol Head Neck Surg. 1999;125:796–800.
Shirley WP, Hill JS, Woolley AL, Wiatrak BJ. Success and complications of four-duct ligation for sialorrhea. Int J Pediatr Otorhinolaryngol. 2003;67:1–6.
Martin TJ, Conley SF. Long-term efficacy of intra-oral surgery for sialorrhea. Otolaryngol Head Neck Surg. 2007;137:54–8.
Chanu NP, Sahni JK, Aneja S, Naglot S. Four-duct ligation in children with drooling. Am J Otolaryngol. 2012;33:604–7.
Khan WU, Islam A, Fu A, et al. Four-duct ligation for the treatment of Sialorrhea in children. JAMA Otolaryngol Head Neck Surg. 2016;
Grewal DS, Hiranandani NL, Rangwalla ZA, Sheode JH. Transtympanic neurectomies for control of drooling. Auris Nasus Larynx. 1984;11:109–14.
Mullins WM, Gross CW, Moore JM. Long-term follow-up of tympanic neurectomy for sialorrhea. Laryngoscope. 1979;89:1219–23.
Grant R, Miller S, Simpson D, Lamey PJ, Bone I. The effect of chorda tympani section on ipsilateral and contralateral salivary secretion and taste in man. J Neurol Neurosurg Psychiatry. 1989;52:1058–62.
Parisier SC, Blitzer A, Binder WJ, Friedman WF, Marovitz WF. Tympanic neurectomy and chorda tympanectomy for the control of drooling. Arch Otolaryngol. 1978;104:273–7.
Spock T, Hoffman HT, Joshi AS. Transoral submandibular ganglion neurectomy: an anatomical feasibility study. Ann Otol Rhinol Laryngol. 2015;124:341–4.
Borg M, Hirst F. The role of radiation therapy in the management of sialorrhea. Int J Radiat Oncol Biol Phys. 1998;41:1113–9.
Neppelberg E, Haugen DF, Thorsen L, Tysnes OB. Radiotherapy reduces sialorrhea in amyotrophic lateral sclerosis. Eur J Neurol. 2007;14:1373–7.
Bourry N, Guy N, Achard JL, Verrelle P, Clavelou P, Lapeyre M. Salivary glands radiotherapy to reduce sialorrhea in amyotrophic lateral sclerosis: dose and energy. Cancer Radiother. 2013;17:191–5.
Guy N, Bourry N, Dallel R, et al. Comparison of radiotherapy types in the treatment of sialorrhea in amyotrophic lateral sclerosis. J Palliat Med. 2011;14:391–5.
Assouline A, Levy A, Abdelnour-Mallet M, et al. Radiation therapy for hypersalivation: a prospective study in 50 amyotrophic lateral sclerosis patients. Int J Radiat Oncol Biol Phys. 2014;88:589–95.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG
About this chapter
Cite this chapter
Withrow, K., Chung, T. (2018). Sialorrhea. In: Gillespie, M., Walvekar, R., Schaitkin, B., Eisele, D. (eds) Gland-Preserving Salivary Surgery. Springer, Cham. https://doi.org/10.1007/978-3-319-58335-8_17
Download citation
DOI: https://doi.org/10.1007/978-3-319-58335-8_17
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-58333-4
Online ISBN: 978-3-319-58335-8
eBook Packages: MedicineMedicine (R0)