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Pancreatic Cancer Epidemiology and Environmental Risk Factors

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Current and Emerging Therapies in Pancreatic Cancer

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Abstract

Pancreatic cancer is one of the leading causes of cancer death worldwide. It is currently the fourth leading cause of cancer-related deaths in both men and women in the United States and has a less than 10% 5-year survival rate for all stages combined.

Worldwide, pancreatic cancer is the eighth leading cause of cancer death in men and the ninth leading cause of cancer death in women. Over 85% of exocrine pancreatic cancers are adenocarcinomas with other variants making up the rest. Risk factors are mainly idiopathic but with some familial cases. Some of the nonfamilial risk factors include smoking, alcohol, diabetes, impaired glucose metabolism and obesity. Analysis from the SEER database in the United States reveals African Americans having the highest incidence of pancreatic cancer and American Indian/Alaska natives appear to be at lowest risk.

This chapter reviews inherited risk factors, genetic predisposition syndromes, environmental factors and other risk factors for pancreatic cancer including association with medications as well as screening and suggested surveillance in pancreatic cancer.

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Authors and Affiliations

  1. Division of Hematology and Oncology, University of Cincinnati, 3125 Eden Ave, Cincinnati, OH, 45219, USA

    Mahender Yellu M.D. & Olugbenga O. Olowokure M.D.

  2. Department of Internal Medicine, University of Cincinnati, Cincinnati, OH, USA

    Chandana Kamireddy M.D.

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  1. Mahender Yellu M.D.
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  2. Chandana Kamireddy M.D.
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Correspondence to Olugbenga O. Olowokure M.D. .

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Editors and Affiliations

  1. Mayo Clinic Cancer Center, Scottsdale, Arizona, USA

    Tanios Bekaii-Saab

  2. Winship Cancer Institute, Emory University, Atlanta, Georgia, USA

    Bassel El-Rayes

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Yellu, M., Kamireddy, C., Olowokure, O.O. (2018). Pancreatic Cancer Epidemiology and Environmental Risk Factors. In: Bekaii-Saab, T., El-Rayes, B. (eds) Current and Emerging Therapies in Pancreatic Cancer . Springer, Cham. https://doi.org/10.1007/978-3-319-58256-6_1

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