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Structures and Functions of Peptidylarginine Deiminases

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Book cover Protein Deimination in Human Health and Disease

Abstract

Molecular structures of peptidylarginine deiminase (PAD) isozymes are strongly associated with their functions. This chapter summarizes the X-ray structures of PAD1, PAD2, and PAD4 as well as that of the PAD from the periodontal pathogen Porphyromonas gingivalis. It is interesting to understand structural differences among these isozymes in detail and to discuss their association with the function of each isozyme. These structures also provide critical insights that will aid in the development of isozyme-selective PAD inhibitors.

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Author information

Authors and Affiliations

  1. Graduate School of Science and Engineering, Ibaraki University, Hitachi, Japan

    Masaki Unno

  2. Frontier Research Center for Applied Atomic Sciences, Ibaraki University, Tokai-mura, Japan

    Masaki Unno & Hidenari Takahara

  3. Kao Corporation, Biological Science Research Laboratory, Odawara, Japan

    Kenji Kizawa

  4. College of Agriculture, Ibaraki University, Ami Inashiki, Japan

    Hidenari Takahara

Authors
  1. Masaki Unno
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  2. Kenji Kizawa
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  3. Hidenari Takahara
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Corresponding author

Correspondence to Masaki Unno .

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Editors and Affiliations

  1. Department of Neurology, University of Alabama at Birmingham and The Birmingham Veterans Administration Medical Center, Birmingham, Alabama, USA

    Anthony P. Nicholas

  2. Bascom Palmer Eye Institute, University of Miami, Miami, Florida, USA

    Sanjoy K. Bhattacharya

  3. Department of Biochemistry and Molecular Pharmacology, UMASS Medical School, Worcester, Massachusetts, USA

    Paul R. Thompson

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Unno, M., Kizawa, K., Takahara, H. (2017). Structures and Functions of Peptidylarginine Deiminases. In: Nicholas, A., Bhattacharya, S., Thompson, P. (eds) Protein Deimination in Human Health and Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-58244-3_3

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