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Bronchoscopy Role in Interstitial Lung Disease

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Interventions in Pulmonary Medicine
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Abstract

Bronchoscopy is considered an important procedure in interstitial lung diseases (ILD) since it can lead to or discards a diagnosis in many cases. The macroscopic and microscopic (cytological or histological) evaluation of samples obtained through bronchoscopy is often needed. During the last years, different advances have increased the value of this technique in the algorithm of ILD diagnosis; (1) thoracic high-resolution computed tomography (HRCT) has enhanced the diagnostic approach and the guided bronchoscopic procedure, (2) improved options for obtaining lung samples, such as transbronchial lung biopsy by cryoprobes, have increased the quality of taken samples. Frequently, bronchoalveolar lavage (BAL) and transbronchial lung biopsy (TBLB) play a significant role in making an accurate diagnosis of specific forms of ILD. However, the standardization of TBLB and BAL protocols and the correct interpretation of thoracic HRCT for the procedure indication are crucial for optimizing the usefulness of both techniques.

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References

  1. Costabel U, Guzman J. Bronchoalveolar lavage in interstitial lung disease. Curr Opin Pulm Med. 2001;7:255–61.

    Article  CAS  PubMed  Google Scholar 

  2. Travis WD, King TE, Bateman ED, et al. ATS/ERS international multidisciplinary consensus classification of idiopathic interstitial pneumonias. General principles and recommendations. Am J Respir Crit Care Med. 2002;165:277–304.

    Article  Google Scholar 

  3. Bradley B, Branley HM, Egan JJ, Greaves MS, Hansell DM, Harrison NK, et al. British Thoracic Society Interstitial Lung Disease Guideline Group. British Thoracic Society Standards of Care Committee; Thoracic Society of Australia; New Zeeland Thoracic Society; Irish Thoracic Society. Interstitial lung disease guideline: the British Thoracic Society in collaboration with the Thoracic Society of Australia and New Zealand and the Irish Thoracic Society. Thorax. 2008;63(Suppl 5):v1–58.

    PubMed  Google Scholar 

  4. Xaubet A, Ancochea J, Blanquer R, Montero C, Morell F, Rodríguez Becerra E, Sueiro A, Villena V; Grupo de Investigación en Enfermedades Pulmonares Intersticiales Difusas. Area de Técnicas y Transplante. SEPAR. Diagnosis and treatment of diffuse interstitial lung diseases. Arch Bronconeumol. 2003;39(12):580–600.

    Google Scholar 

  5. Drent M, Meyer KC, Baughman RP. Bronchoalveolar lavage. Prog Respir Res. 2007;36:58–67.

    Article  Google Scholar 

  6. Kanne JP. Interstitial lung disease (ILD): imaging finding, and the role of imaging in the evaluating the patient with known or suspected ILD. Semin Soentgenol. 2010;45:3.

    Article  Google Scholar 

  7. Meyer KC. Bronchoalveolar lavage as a diagnostic tool. Semin Respir Crit Care Med. 2007;28:546–60.

    Article  PubMed  Google Scholar 

  8. Meyer KC. The role of bronchoalveolar lavage in interstitial lung disease. Clin Chest Med. 2004;25(4):637–49, v.

    Article  PubMed  Google Scholar 

  9. Ryu JH, Daniels CE, Hartman TE, Yi ES. Diagnosis of interstitial lung diseases. Mayo Clinc Proc. 2007;82(8):976–86.

    Article  Google Scholar 

  10. Baughman RP. Technical aspects of bronchoalveolar lavage: recommendations for a standard procedure. Semin Respir Crit Care Med. 2007;28:475–85.

    Article  PubMed  Google Scholar 

  11. Dhillon DP, Haslam PL, Townsend PJ, et al. Bronchoalveolar lavage in patients with interstitial lung diseases: side effects and factors affecting fluid recovery. Eur J Respir Dis. 1986;68:341–50.

    Google Scholar 

  12. Dohn MN, Baughman RP. Effect of changing instilled volume for bronchoalveolar lavage in patients with interstitial lung disease. Am Rev Respir Dis. 1985;132:390–2.

    CAS  PubMed  Google Scholar 

  13. Rosell A, Xaubet A, Agustí C, Castella J, Puzo C, Curull V, de Gracia J. RASTA study group. A new BAL fluid instillation and aspiration technique: a multicenter randomized study. Respir Med. 2006;100(3):529–35.

    Article  PubMed  Google Scholar 

  14. Costabel U, Guzman J. Effect of smoking on bronchoalveolar lavage constituents. Eur Respir J. 1992;5:776–9.

    CAS  PubMed  Google Scholar 

  15. Meyer KC, Soergel P. Bronchoalveolar lymphocyte phenotypes change in the normal aging human lung. Thorax. 1999;54:697–700.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Haslam PL, Baughmann RP, editors. Guidelines for the measurement of acellular components and recommendations for standardization of bronchoalveolar lavage (BAL). Eur Respir Rev. 1999;9:25–157.

    Google Scholar 

  17. Baughman RP, Drent M. Role of bronchoalveolar lavage in interstitial lung disease. Clin Chest Med. 2001;22:331–41.

    Article  CAS  PubMed  Google Scholar 

  18. Raghu G. Is bronchoalveolar lavage clinically useful for everyday practice in interstitial lung disease? Con: bronchoalveolar lavage. J Bronchology. 1999;6:217–21.

    Article  Google Scholar 

  19. Meyer KC, Raghu G. Bronchoalveolar lavage for the evaluation of interstitial lung disease: is it clinically useful? Eur Respir J. 2011;38(4):761–9.

    Article  CAS  PubMed  Google Scholar 

  20. Martin RJ, Coalson JJ, Roger RM, et al. Pulmonary alveolar proteinosis: the diagnosis by segmental lavage. Am Rev Respir Dis. 1980;121:819–25.

    CAS  PubMed  Google Scholar 

  21. Allen JN, Davis WB. Eosinophilic lung diseases. Am J Respir Crit Care Med. 1994;150:1423–38.

    Article  CAS  PubMed  Google Scholar 

  22. Raghu G, Collard HR, Egan JJ, et al. An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. Am J Respir Crit Care Med. 2011;183:788–824.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Raghu G. Idiopathic pulmonary fibrosis: guidelines for diagnosis and clinical management have advanced from consensus-based in 2000 to evidence-based in 2011. Eur Respir J. 2011;37:743–6.

    Article  CAS  PubMed  Google Scholar 

  24. Welker L, Jörres RA, Costabel U, et al. Predictive value of BAL cell differentials in the diagnosis of interstitial lung diseases. Eur Respir J. 2004;24:1000–6.

    Article  CAS  PubMed  Google Scholar 

  25. Drent M, Mansour K, Linssen C. Bronchoalveolar lavage in sarcoidosis. Semin Respir Crit Care Med. 2007;28:486–95.

    Article  PubMed  Google Scholar 

  26. Costabel U, Guzman J, Bonella F, et al. Bronchoalveolar lavage in other interstitial lung diseases. Semin Respir Crit Care Med. 2007;28:514–24.

    Article  PubMed  Google Scholar 

  27. Hernandez Blasco L, Sanchez Hernandez IM, Villena Garrido V, de Miguel Poch E, Delgado Nuñez M, Alfaro Abreu J. Safety of the transbronchial biopsy in outpatients. Chest. 1991;99:562–5.

    Article  CAS  PubMed  Google Scholar 

  28. Churg A. Transbronchial biopsy: nothing to fear. Am J Rusg Pathol. 2001;25:820–2.

    Article  CAS  Google Scholar 

  29. Margaritopoulos GA, Wells AU. The role of transbronchial biopsy in the diagnosis of diffuse parenchymal lung diseases: con. Rev Port Pneumol. 2012;18(2):61–3.

    Article  CAS  PubMed  Google Scholar 

  30. Poletti V, Casoni GL, Cancellieri A, Piciucchi S, Dubini A, Zompatori M. Diffuse alveolar damage. Pathologica. 2012;102:453–63.

    Google Scholar 

  31. Leslie KO, Gruden JF, Parish JM, Scholand MB. Transbronchial biopsy interpretation in the patient with diffuse parenchymal lung disease. Arch Pathol Lab Med. 2007;131(3):407–23.

    PubMed  Google Scholar 

  32. Colby TV, Fukuoka J, Ewaskow SP, Helmers R, Leslie KO. Pathologic approach to pulmonary hemorrhage. Ann Diagn Pathol. 2001;5:309–19.

    Article  CAS  PubMed  Google Scholar 

  33. Oliveira CC, Fabro AT, Ribeiro SM, Defaveri J, Capelozzi VL, Queluz TH, Yoo HH. Evaluation of the use of transbronchial biopsy in patients with clinical suspicion of interstitial lung disease. J Bras Pneumol. 2011;37(2):168–75.

    Article  CAS  PubMed  Google Scholar 

  34. Pajares V, Torrego A, Puzo C, Lerma E, Gil De Bernabé MA, Franquet T. Transbronchial lung biopsy using cryoprobes. Arch Bronconeumol. 2010;46:111–5.

    Article  PubMed  Google Scholar 

  35. Babiak A, Hetzel J, Krishna G, et al. Transbronchial cryobiopsy: a new tool for lung biopsies. Respiration. 2009;78:203–8.

    Article  PubMed  Google Scholar 

  36. Franke KJ, Theegarten D, Hann von Weyhern C, et al. Prospective controlled animal study on biopsy sampling with new flexible cryoprobes versus forceps: evaluation of biopsy size, histological quality and bleeding risk. Respiration. 2010;80(2):127–32.

    Article  PubMed  Google Scholar 

  37. Griff S, Ammenwerth W, Schönfeld N, et al. Morphometrical analysis of transbronchial cryobiopsies. Diagn Pathol. 2011;6:53.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Johannson KA, Marcoux VS, Ronksley PE, Ryerson CJ. Diagnostic yield and complications of transbronchial lung cryobiopsy for interstitial lung disease: a systematic review and meta-analysis. Ann Am Thorac Soc. 2016;13(10):1828–38.

    PubMed  Google Scholar 

  39. Tomassetti S, Wells AU, Costabel U, et al. Bronchoscopic lung cryobiopsy increases diagnostic confidence in the multidisciplinary diagnosis of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2016;193(7):745–52.

    Article  PubMed  Google Scholar 

  40. Poletti V, Ravaglia C, Tomassetti S. Transbronchial cryobiopsy in diffuse parenchymal lung diseases. Curr Opin Pulm Med. 2016;22(3):289–96.

    Article  PubMed  Google Scholar 

  41. Martin WJ, Iannuzzi MC, Gail DB, Peavy HH. Future directions in sarcoidosis research: summary of an NHLBI working group. Am J Respir Crit Care Med. 2004;170:567–71.

    Article  PubMed  Google Scholar 

  42. Costello LC, Hartman TE, Ryu JH. High frequency of pulmonary lymphangioleiomyomatosis in women with tuberous sclerosis complex. Mayo Clin Proc. 2000;75:591–4.

    Article  CAS  PubMed  Google Scholar 

  43. Agostini C, Miorin M, Semenzato G. Gene expression profile analysis by DNA microarrays: a new approach to assess functional genomics in diseases. Sarcoidosis Vasc Diffuse Lung Dis. 2002;19:5–9.

    PubMed  Google Scholar 

  44. Thornhofer R, Maercker C, Popper HH. Expression of sarcoidosis related genes in lung lavage cells. Sarcoidosis Vasc Diffuse Lung Dis. 2002;19:59–65.

    Google Scholar 

  45. Selman M, Pardo A, Barrera L, et al. Gene expression profiles distinguish idiopathic pulmonary fibrosis from hypersensitivity pneumonitis. Am J Respir Crit Care Med. 2006;173:188–98.

    Article  CAS  PubMed  Google Scholar 

  46. Magi B, Bini L, Perari MG, et al. Bronchoalveolar lavage fluid protein composition in patients with sarcoidosis and idiopathic pulmonary fibrosis: a two-dimensional electrophoretic study. Electrophoresis. 2002;23:3434–44.

    Article  CAS  PubMed  Google Scholar 

  47. Rottoli P, Magi B, Perari MG, et al. Cytokine profile and proteome analysis in bronchoalveolar lavage of patients with sarcoidosis, pulmonary fibrosis associated with systemic sclerosis and idiopathic pulmonary fibrosis. Proteomics. 2005;5:1423–30.

    Article  CAS  PubMed  Google Scholar 

  48. De Torre C, Ying S, Munson PJ, et al. Proteomic analysis of inflammatory biomarkers in bronchoalveolar lavage. Proteomics. 2006;6:3949–57.

    Article  PubMed  Google Scholar 

  49. Bowler RP, Ellison MC, Reisdorph N. Proteomics in pulmonary medicine. Chest. 2006;130:567–74.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Maria Molina-Molina MD .

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Molina-Molina, M. (2018). Bronchoscopy Role in Interstitial Lung Disease. In: Díaz-Jimenez, J., Rodriguez, A. (eds) Interventions in Pulmonary Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-58036-4_35

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  • DOI: https://doi.org/10.1007/978-3-319-58036-4_35

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