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Neurologic Complications of Hematopoietic Stem Cell Transplantation

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Cancer Neurology in Clinical Practice

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Abstract

Despite significant advances since the first human bone marrow transplant in the 1950s, hematopoietic stem cell transplantation (HSCT) is still associated with significant morbidity and mortality. This chapter focuses on the main neurologic complications associated with HSCT, including encephalopathy, seizures, central nervous system infections, and neurologic conditions directly associated with graft versus host disease. The underlying causes of the neurologic complication are numerous, including chemoradiotoxicity, medication toxicity, metabolic abnormalities, organ failure, graft versus host disease, infection, pancytopenia, and platelet dysfunction. The timing since transplant occasionally dictates which neurologic complications are more likely to occur.  

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References

  1. Saiz A, Graus F. Neurologic complications of hematopoietic cell transplantation. Semin Neurol. 2010;30(3):287–95.

    Article  PubMed  Google Scholar 

  2. Copelan EA. Hematopoietic stem-cell transplantation. N Engl J Med. 2006;354(17):1813–26.

    Article  CAS  PubMed  Google Scholar 

  3. Pasquini MC, Zhu X. Current uses and outcomes of hematopoietic stem cell transplantation: 2014 CIBMTR Summary Slides 2014 [June 29, 2015]. Available from: http://www.cibmtr.org/referencecenter/slidesreports/summaryslides/pages/index.aspx.

  4. Little M-T, Storb R. History of haematopoietic stem-cell transplantation. Nat Rev Cancer. 2002;2(3):231–8.

    Article  CAS  PubMed  Google Scholar 

  5. Antonini G, Ceschin V, Morino S, Fiorelli M, Gragnani F, Mengarelli A, et al. Early neurologic complications following allogeneic bone marrow transplant for leukemia: a prospective study. Neurology. 1998;50(5):1441–5.

    Article  CAS  PubMed  Google Scholar 

  6. Bleggi-Torres LF, de Medeiros BC, Werner B, Neto JZ, Loddo G, Pasquini R, et al. Neuropathological findings after bone marrow transplantation: an autopsy study of 180 cases. Bone Marrow Transplant. 2000;25(3):301–7.

    Article  CAS  PubMed  Google Scholar 

  7. Gordon B, Lyden E, Lynch J, Tarantolo S, Pavletic ZS, Bishop M, et al. Central nervous system dysfunction as the first manifestation of multiple organ dysfunction syndrome in stem cell transplant patients. Bone Marrow Transplant. 2000;25(1):79–83.

    Article  CAS  PubMed  Google Scholar 

  8. Bhatt VR, Balasetti V, Abduall JJ, Giri S, Armitage JO, Loberiza FR Jr, et al. Central nervous system complications and outcomes after allogeneic hematopoietic stem cell transplantation. Clin Lymphoma Myeloma Leuk. 2015;15(10):606–11.

    Article  PubMed  Google Scholar 

  9. Rosenfeld MR, Pruitt A. Neurologic complications of bone marrow, stem cell, and organ transplantation in patients with cancer. Semin Oncol. 2006;33(3):352–61.

    Article  PubMed  Google Scholar 

  10. Kang JM, Kim YJ, Kim JY, Cho EJ, Lee JH, Lee MH, et al. Neurologic complications after allogeneic hematopoietic stem cell transplantation in children: analysis of prognostic factors. Biol Blood Marrow Transplant J Am Soc Blood Marrow Transplant. 2015;21(6):1091–8.

    Article  Google Scholar 

  11. Jackson SR, Tweeddale MG, Barnett MJ, Spinelli JJ, Sutherland HJ, Reece DE, et al. Admission of bone marrow transplant recipients to the intensive care unit: outcome, survival and prognostic factors. Bone Marrow Transplant. 1998;21(7):697–704.

    Article  CAS  PubMed  Google Scholar 

  12. Woodard P, Helton K, McDaniel H, Khan RB, Thompson S, Hale G, et al. Encephalopathy in pediatric patients after allogeneic hematopoietic stem cell transplantation is associated with a poor prognosis. Bone Marrow Transplant. 2004;33(11):1151–7.

    Article  CAS  PubMed  Google Scholar 

  13. Baker WJ, Royer GL Jr, Weiss RB. Cytarabine and neurologic toxicity. J Clin Oncol. 1991;9(4):679–93.

    Article  CAS  PubMed  Google Scholar 

  14. Cheson BD, Vena DA, Foss FM, Sorensen JM. Neurotoxicity of purine analogs: a review. J Clin Oncol. 1994;12(10):2216–28.

    Article  CAS  PubMed  Google Scholar 

  15. Beitinjaneh AM, McKinney AM, Cao Q, Weisdorf DJ. Toxic Leukoencephalopathy following Fludarabine-associated hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2011;17(3):300–8.

    Article  CAS  PubMed  Google Scholar 

  16. Snavely SR, Hodges GR. The neurotoxicity of antibacterial agents. Ann Intern Med. 1984;101(1):92–104.

    Article  CAS  PubMed  Google Scholar 

  17. Grill MF, Maganti RK. Neurotoxic effects associated with antibiotic use: management considerations. Br J Clin Pharmacol. 2011;72(3):381–93.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Berry L, Venkatesan P. Aciclovir-induced neurotoxicity: utility of CSF and serum CMMG levels in diagnosis. J Clin Virol. 2014;61(4):608–10.

    Article  CAS  Google Scholar 

  19. McDonald GB. Hepatobiliary complications of hematopoietic cell transplantation, 40 years on. Hepatology. 2010;51(4):1450–60.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Fan CQ, Crawford JM. Sinusoidal obstruction syndrome (hepatic veno-occlusive disease). J Clin Exp Hepatol. 2014;4(4):332–46.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Haire WD. Multiple organ dysfunction syndrome in hematopoietic stem cell transplantation. Crit Care Med. 2002;30(5 Suppl):S257–62.

    Article  PubMed  Google Scholar 

  22. Beitinjaneh A, McKinney AM, Cao Q, Weisdorf DJ. Toxic leukoencephalopathy following fludarabine-associated hematopoietic cell transplantation. Biol Blood Marrow Transplant J Am Soc Blood Marrow Transplant. 2011;17(3):300–8.

    Article  CAS  Google Scholar 

  23. Hammerstrom AE, Howell J, Gulbis A, Rondon G, Champlin RE, Popat U. Tacrolimus-associated posterior reversible encephalopathy syndrome in hematopoietic allogeneic stem cell transplantation. Am J Hematol. 2013;88(4):301–5.

    Article  CAS  PubMed  Google Scholar 

  24. Memon M, deMagalhaes-Silverman M, Bloom EJ, Lister J, Myers DJ, Pincus SM, et al. Reversible cyclosporine-induced cortical blindness in allogeneic bone marrow transplant recipients. Bone Marrow Transplant. 1995;15(2):283–6.

    CAS  PubMed  Google Scholar 

  25. Steg RE, Kessinger A, Wszolek ZK. Cortical blindness and seizures in a patient receiving FK506 after bone marrow transplantation. Bone Marrow Transplant. 1999;23(9):959–62.

    Article  CAS  PubMed  Google Scholar 

  26. Zhang XH, Xu LP, Liu DH, Chen H, Han W, Chen YH, et al. Epileptic seizures in patients following allogeneic hematopoietic stem cell transplantation: a retrospective analysis of incidence, risk factors, and survival rates. Clin Transplant. 2013;27(1):80–9.

    Article  PubMed  Google Scholar 

  27. Ciurea SO, Andersson BS. Busulfan in hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2009;15(5):523–36.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Busulfan. In: DRUGDEX System [Internet database] Greenwood Village, CO: Thomas Reuters (Healthcare) Inc. Updated periodically.

    Google Scholar 

  29. Soni S, Skeens M, Termuhlen AM, Bajwa RP, Gross TG, Pai V. Levetiracetam for busulfan-induced seizure prophylaxis in children undergoing hematopoietic stem cell transplantation. Pediatr Blood Cancer. 2012;59(4):762–4.

    Article  PubMed  Google Scholar 

  30. Caselli D, Rosati A, Faraci M, Podda M, Ripaldi M, Longoni D, et al. Risk of seizures in children receiving busulphan-containing regimens for stem cell transplantation. Biol Blood Marrow Transplant J Am Soc Blood Marrow Transplant. 2014;20(2):282–5.

    Article  CAS  Google Scholar 

  31. Maschke M, Dietrich U, Prumbaum M, Kastrup O, Turowski B, Schaefer UW, et al. Opportunistic CNS infection after bone marrow transplantation. Bone Marrow Transplant. 1999;23(11):1167–76.

    Article  CAS  PubMed  Google Scholar 

  32. de Medeiros BC, de Medeiros CR, Werner B, Neto JZ, Loddo G, Pasquini R, et al. Central nervous system infections following bone marrow transplantation: an autopsy report of 27 cases. J Hematother Stem Cell Res. 2000;9(4):535–40.

    Article  PubMed  Google Scholar 

  33. Guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients. MMWR Recomm Rep. 2000;49(RR-10):1–125, CE1-7.

    Google Scholar 

  34. Dykewicz CA. Centers for Disease C, Prevention, Infectious Diseases Society of A, American Society of B, Marrow T. Summary of the Guidelines for Preventing Opportunistic Infections among Hematopoietic Stem Cell Transplant Recipients. Clin Infect Dis. 2001;33(2):139–44.

    Article  CAS  PubMed  Google Scholar 

  35. Quant EC, Wen PY. Neurological complications of hematopoeitic stem cell transplantation. In: Schiff D, Kesari S, Wen PY, editors. Cancer Neurology in Clinical Practice. 2nd ed. Totowa, New Jersey: Humana Press; 2008. p. 327–52.

    Chapter  Google Scholar 

  36. Saugier-Veber P, Devergie A, Sulahian A, Ribaud P, Traore F, Bourdeau-Esperou H, et al. Epidemiology and diagnosis of invasive pulmonary aspergillosis in bone marrow transplant patients: results of a 5 year retrospective study. Bone Marrow Transplant. 1993;12(2):121–4.

    CAS  PubMed  Google Scholar 

  37. Jantunen E, Volin L, Salonen O, Piilonen A, Parkkali T, Anttila VJ, et al. Central nervous system aspergillosis in allogeneic stem cell transplant recipients. Bone Marrow Transplant. 2003;31(3):191–6.

    Article  CAS  PubMed  Google Scholar 

  38. Walsh TJ, Hier DB, Caplan LR. Aspergillosis of the central nervous system: clinicopathological analysis of 17 patients. Ann Neurol. 1985;18(5):574–82.

    Article  CAS  PubMed  Google Scholar 

  39. Miaux Y, Ribaud P, Williams M, Guermazi A, Gluckman E, Brocheriou C, et al. MR of cerebral aspergillosis in patients who have had bone marrow transplantation. Ajnr. 1995;16(3):555–62.

    CAS  PubMed  Google Scholar 

  40. Guermazi A, Gluckman E, Tabti B, Miaux Y. Invasive central nervous system aspergillosis in bone marrow transplantation recipients: an overview. Eur Radiol. 2003;13(2):377–88.

    PubMed  Google Scholar 

  41. Baslar Z, Soysal T, Hanci M, Aygun G, Ferhanoglu B, Sarioglu AC, et al. Successfully treated invasive central nervous system aspergillosis in an allogeneic stem cell transplant recipient. Bone Marrow Transplant. 1998;22(4):404–5.

    Article  CAS  PubMed  Google Scholar 

  42. Khoury H, Adkins D, Miller G, Goodnough L, Brown R, DiPersio J. Resolution of invasive central nervous system aspergillosis in a transplant recipient. Bone Marrow Transplant. 1997;20(2):179–80.

    Article  CAS  PubMed  Google Scholar 

  43. Ruping MJ, Vehreschild JJ, Cornely OA. Patients at high risk of invasive fungal infections: when and how to treat. Drugs. 2008;68(14):1941–62.

    Article  PubMed  Google Scholar 

  44. Marr KA, Bow E, Chiller T, Maschmeyer G, Ribaud P, Segal B, et al. Fungal infection prevention after hematopoietic cell transplantation. Bone Marrow Transplant. 2009;44(8):483–7.

    Article  CAS  PubMed  Google Scholar 

  45. Richardson M, Lass-Florl C. Changing epidemiology of systemic fungal infections. Clin Microbiol Infect. 2008;14(Suppl 4):5–24.

    Article  PubMed  Google Scholar 

  46. LaRocco MT, Burgert SJ. Infection in the bone marrow transplant recipient and role of the microbiology laboratory in clinical transplantation. Clin Microbiol Rev. 1997;10(2):277–97.

    CAS  PubMed  PubMed Central  Google Scholar 

  47. Hagensee ME, Bauwens JE, Kjos B, Bowden RA. Brain abscess following marrow transplantation: experience at the Fred Hutchinson Cancer Research Center, 1984–1992. Clin Infect Dis. 1994;19(3):402–8.

    Article  CAS  PubMed  Google Scholar 

  48. Centers for Disease Control. Guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients: recommendations of CDC, the Infectious Disease Society of America, and the American Society of Blood and Marrow Transplantation. MMWR. 2000;49:23,6,107.

    Google Scholar 

  49. Mulanovich VE, Ahmed SI, Ozturk T, Khokhar FA, Kontoyiannis DP, de Lima M. Toxoplasmosis in allo-SCT patients: risk factors and outcomes at a transplantation center with a low incidence. Bone Marrow Transplant. 2011;46(2):273–7.

    Article  CAS  PubMed  Google Scholar 

  50. Chandrasekar PH, Momin F. Disseminated toxoplasmosis in marrow recipients: a report of three cases and a review of the literature. Bone Marrow Transplant Team. Bone Marrow Transplant. 1997;19(7):685–9.

    Article  CAS  PubMed  Google Scholar 

  51. Bretagne S, Costa JM, Kuentz M, Simon D, Vidaud M, Fortel I, et al. Late toxoplasmosis evidenced by PCR in a marrow transplant recipient. Bone Marrow Transplant. 1995;15(5):809–11.

    CAS  PubMed  Google Scholar 

  52. Brinkman K, Debast S, Sauerwein R, Ooyman F, Hiel J, Raemaekers J. Toxoplasma retinitis/encephalitis 9 months after allogeneic bone marrow transplantation. Bone Marrow Transplant. 1998;21(6):635–6.

    Article  CAS  PubMed  Google Scholar 

  53. Derouin F, Devergie A, Auber P, Gluckman E, Beauvais B, Garin YJ, et al. Toxoplasmosis in bone marrow-transplant recipients: report of seven cases and review. Clin Infect Dis. 1992;15(2):267–70.

    Article  CAS  PubMed  Google Scholar 

  54. Dietrich U, Maschke M, Dorfler A, Prumbaum M, Forsting M. MRI of intracranial toxoplasmosis after bone marrow transplantation. Neuroradiology. 2000;42(1):14–8.

    Article  CAS  PubMed  Google Scholar 

  55. Tefferi A, O’Neill BP, Inwards DJ. Late-onset cerebral toxoplasmosis after allogeneic bone marrow transplantation. Bone Marrow Transplant. 1998;21(12):1285–6.

    Article  CAS  PubMed  Google Scholar 

  56. Edvinsson B, Lundquist J, Ljungman P, Ringden O, Evengard B. A prospective study of diagnosis of Toxoplasma gondii infection after bone marrow transplantation. APMIS. 2008;116(5):345–51.

    Article  PubMed  Google Scholar 

  57. Cibickova L, Horacek J, Prasil P, Slovacek L, Kohout A, Cerovsky V, et al. Cerebral toxoplasmosis in an allogeneic peripheral stem cell transplant recipient: case report and review of literature. Transpl Infect Dis. 2007;9(4):332–5.

    Article  CAS  PubMed  Google Scholar 

  58. Lowenberg B, van Gijn J, Prins E, Polderman AM. Fatal cerebral toxoplasmosis in a bone marrow transplant recipient with leukemia. Transplantation. 1983;35(1):30–4.

    Article  CAS  PubMed  Google Scholar 

  59. Slavin MA, Meyers JD, Remington JS, Hackman RC. Toxoplasma gondii infection in marrow transplant recipients: a 20 year experience. Bone Marrow Transplant. 1994;13(5):549–57.

    CAS  PubMed  Google Scholar 

  60. Khoury H, Adkins D, Brown R, Goodnough L, Gokden M, Roberts T, et al. Successful treatment of cerebral toxoplasmosis in a marrow transplant recipient: contribution of a PCR test in diagnosis and early detection. Bone Marrow Transplant. 1999;23(4):409–11.

    Article  CAS  PubMed  Google Scholar 

  61. Roemer E, Blau IW, Basara N, Kiehl MG, Bischoff M, Gunzelmann S, et al. Toxoplasmosis, a severe complication in allogeneic hematopoietic stem cell transplantation: successful treatment strategies during a 5-year single-center experience. Clin Infect Dis. 2001;32(1):E1–8.

    Article  CAS  PubMed  Google Scholar 

  62. Mueller-Mang C, Mang TG, Kalhs P, Thurnher MM. Imaging characteristics of toxoplasmosis encephalitis after bone marrow transplantation: report of two cases and review of the literature. Neuroradiology. 2006;48(2):84–9.

    Article  CAS  PubMed  Google Scholar 

  63. Martino R, Maertens J, Bretagne S, Rovira M, Deconinck E, Ullmann AJ, et al. Toxoplasmosis after hematopoietic stem cell transplantation. Clin Infect Dis. 2000;31(5):1188–95.

    Article  CAS  PubMed  Google Scholar 

  64. Ljungman P, Singh N. Human herpesvirus-6 infection in solid organ and stem cell transplant recipients. J Clin Virol. 2006;37(Suppl 1):S87–91.

    Article  CAS  PubMed  Google Scholar 

  65. Ljungman P, de la Camara R, Cordonnier C, Einsele H, Engelhard D, Reusser P, et al. Management of CMV, HHV-6, HHV-7 and Kaposi-sarcoma herpesvirus (HHV-8) infections in patients with hematological malignancies and after SCT. Bone Marrow Transplant. 2008;42(4):227–40.

    Article  CAS  PubMed  Google Scholar 

  66. Bosi A, Zazzi M, Amantini A, Cellerini M, Vannucchi AM, De Milito A, et al. Fatal herpesvirus 6 encephalitis after unrelated bone marrow transplant. Bone Marrow Transplant. 1998;22(3):285–8.

    Article  CAS  PubMed  Google Scholar 

  67. Singh N, Paterson DL. Encephalitis caused by human herpesvirus-6 in transplant recipients: relevance of a novel neurotropic virus. Transplantation. 2000;69(12):2474–9.

    Article  CAS  PubMed  Google Scholar 

  68. Ogata M, Fukuda T, Teshima T. Human herpesvirus-6 encephalitis after allogeneic hematopoietic cell transplantation: what we do and do not know. Bone Marrow Transplant. 2015;50(8):1030–6.

    Article  CAS  PubMed  Google Scholar 

  69. Gorniak RJ, Young GS, Wiese DE, Marty FM, Schwartz RB. MR imaging of human herpesvirus-6-associated encephalitis in 4 patients with anterograde amnesia after allogeneic hematopoietic stem-cell transplantation. AJNR Am J Neuroradiol. 2006;27(4):887–91.

    CAS  PubMed  Google Scholar 

  70. Wainwright MS, Martin PL, Morse RP, Lacaze M, Provenzale JM, Coleman RE, et al. Human herpesvirus 6 limbic encephalitis after stem cell transplantation. Ann Neurol. 2001;50(5):612–9.

    Article  CAS  PubMed  Google Scholar 

  71. Wang FZ, Linde A, Hagglund H, Testa M, Locasciulli A, Ljungman P. Human herpesvirus 6 DNA in cerebrospinal fluid specimens from allogeneic bone marrow transplant patients: does it have clinical significance? Clin Infect Dis. 1999;28(3):562–8.

    Article  CAS  PubMed  Google Scholar 

  72. Demeter L. JC, BK, and other polyomavirus; progressive multifocal leukoencephalopathy. In: Mandell G, Bennett J, Dolin R, editors. Principles and practice of infectious diseases. 5th edition ed. London: Churchill Livingstone; 2000:1645–51.

    Google Scholar 

  73. Re D, Bamborschke S, Feiden W, Schroder R, Lehrke R, Diehl V, et al. Progressive multifocal leukoencephalopathy after autologous bone marrow transplantation and alpha-interferon immunotherapy. Bone Marrow Transplant. 1999;23(3):295–8.

    Article  CAS  PubMed  Google Scholar 

  74. Przepiorka D, Jaeckle KA, Birdwell RR, Fuller GN, Kumar AJ, Huh YO, et al. Successful treatment of progressive multifocal leukoencephalopathy with low-dose interleukin-2. Bone Marrow Transplant. 1997;20(11):983–7.

    Article  CAS  PubMed  Google Scholar 

  75. Coplin WM, Cochran MS, Levine SR, Crawford SW. Stroke after bone marrow transplantation: frequency, aetiology and outcome. Brain J Neurol. 2001;124(Pt 5):1043–51.

    Article  CAS  Google Scholar 

  76. Najima Y, Ohashi K, Miyazawa M, Nakano M, Kobayashi T, Yamashita T, et al. Intracranial hemorrhage following allogeneic hematopoietic stem cell transplantation. Am J Hematol. 2009;84(5):298–301.

    Article  PubMed  Google Scholar 

  77. Pomeranz S, Naparstek E, Ashkenazi E, Nagler A, Lossos A, Slavin S, et al. Intracranial haematomas following bone marrow transplantation. J Neurol. 1994;241(4):252–6.

    Article  CAS  PubMed  Google Scholar 

  78. Hefzy HM, Bartynski WS, Boardman JF, Lacomis D. Hemorrhage in posterior reversible encephalopathy syndrome: imaging and clinical features. AJNR Am J Neuroradiol. 2009;30(7):1371–9.

    Article  CAS  PubMed  Google Scholar 

  79. Tichelli A, Bhatia S, Socie G. Cardiac and cardiovascular consequences after haematopoietic stem cell transplantation. Br J Haematol. 2008;142(1):11–26.

    Article  PubMed  Google Scholar 

  80. Tichelli A, Bucher C, Rovo A, Stussi G, Stern M, Paulussen M, et al. Premature cardiovascular disease after allogeneic hematopoietic stem-cell transplantation. Blood. 2007;110(9):3463–71.

    Article  CAS  PubMed  Google Scholar 

  81. Colosimo M, McCarthy N, Jayasinghe R, Morton J, Taylor K, Durrant S. Diagnosis and management of subdural haematoma complicating bone marrow transplantation. Bone Marrow Transplant. 2000;25(5):549–52.

    Article  CAS  PubMed  Google Scholar 

  82. Blazar BR, Murphy WJ, Abedi M. Advances in graft-versus-host disease biology and therapy. Nat Rev Immunol. 2012;12(6):443–58.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  83. Socie G, Ritz J. Current issues in chronic graft-versus-host disease. Blood. 2014;124(3):374–84.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  84. Delios AM, Rosenblum M, Jakubowski AA, DeAngelis LM. Central and peripheral nervous system immune mediated demyelinating disease after allogeneic hemopoietic stem cell transplantation for hematologic disease. J Neurooncol. 2012;110(2):251–6.

    Article  CAS  PubMed  Google Scholar 

  85. Kannan K, Koh LP, Linn YC. Subdural hematoma in two hematopoietic stem cell transplant patients with post-dural puncture headache and initially normal CT brain scan. Ann Hematol. 2002;81(9):540–2.

    Article  CAS  PubMed  Google Scholar 

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  1. Center for Neuro-Oncology, Dana-Farber/Brigham and Women’s Cancer Center, 450 Brookline Avenue, Boston, MA, 02215, USA

    Eudocia Q. Lee & Patrick Y. Wen

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  1. Eudocia Q. Lee
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Editors and Affiliations

  1. Harrison Distinguished Teaching, Professor of Neurology, Neurological Surgery, and Medicine, University of Virginia, Charlottesville, Virginia, USA

    David Schiff

  2. Instructor, Harvard Medical School, Massachusetts General Hospital, Department of Neurology/Neuro-Oncology, Boston, Massachusetts, USA

    Isabel Arrillaga

  3. Professor of Neurology, Harvard Medical School, Dana-Farber/Brigham and Women’s Cancer Center, Center for Neuro-Oncology, Boston, Massachusetts, USA

    Patrick Y. Wen

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Lee, E.Q., Wen, P.Y. (2018). Neurologic Complications of Hematopoietic Stem Cell Transplantation. In: Schiff, D., Arrillaga, I., Wen, P. (eds) Cancer Neurology in Clinical Practice. Springer, Cham. https://doi.org/10.1007/978-3-319-57901-6_18

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