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Brain Metastases pp 213–231Cite as

Renal Cell Carcinoma (RCC)

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Abstract

Renal cell carcinoma (RCC) is the most common malignant tumor of the kidney, accounting for about 80–90% of kidney tumors in adults and about 2–3% of all new cancer cases (Mori et al. 1998). RCC occurs twice as likely in men as in women, with the highest incidence in the age of 50–70 years (Muscat 2000). Each year, 30,000 and 20,000 new cases of kidney cancer are reported in the USA and in the European Union, respectively (Kirkali et al. 2001). In Russia, RCC occupies one of the first places among all forms of cancer in terms of the incidence rate: the number of cases in recent years approaches 20 thousand per year. Mortality rates from this disease in Russia are also high, 8000–9000 per year, accounting for 2–3% of all deaths of patients with malignant tumors. The 5-year survival in patients is 80–90% and 5–10% with localized and disseminated RCC forms, respectively (Motzer et al. 2004).

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Bibliography

  • Badalament R, Kreutzer E, Gluck R, et al. Surgical treatment of brain metastases from renal cell carcinoma. Urology. 1990;36:112–7.

    Article  CAS  PubMed  Google Scholar 

  • Baltaci S, Orhan D, Soyupek S, et al. Influence of tumor stage, size, grade, vascular involvement, histological cell type and histological pattern on multifocality of renal cell carcinoma. J Urol. 2000;164(1):36–9.

    Article  CAS  PubMed  Google Scholar 

  • Bianchi M, Sun M, Jeldres C, et al. Distribution of metastatic sites in renal cell carcinoma: a population-based analysis. Ann Oncol. 2012;23(4):973–80.

    Article  CAS  PubMed  Google Scholar 

  • Blanco A, Teh S, Amato R. Role of radiation therapy in the management of renal cell cancer. Cancers. 2011;3:4010–23.

    Article  PubMed  PubMed Central  Google Scholar 

  • Clague J, Lin J, Cassidy A, et al. Family history and risk of renal cell carcinoma: results from a case–control study and systematic meta-analysis. Cancer Epidemiol Biomark Prev. 2009;18:801–7.

    Article  Google Scholar 

  • Coppic C, Porzsot F, Awa A, et al. Immunotherapy for advanced renal cancer. Cochrane Database Syst Rev. 2000;1:CD001425.

    Google Scholar 

  • Coughlin S, Neaton J, Randall B, et al. Predictors of mortality from kidney cancer in 332 547 men screened for the Multiple Risk Factor Intervention Trial. Cancer. 1997;79:2171–7.

    Article  CAS  PubMed  Google Scholar 

  • Crispen P, Lohse C, Blute M. Multifocal renal cell carcinoma: clinicopathologic features and outcomes for tumors ≤4 cm. Adv Urol. 2008;2008:7.

    Article  Google Scholar 

  • Davydov MI, Axel EM. Statistics of malignancies in Russia and the CIS in 2012. Moscow: IOP Science; 2014a. p. 39–42.

    Google Scholar 

  • Davydov MI, Axel EM. Statistics of malignancies in Russia and the CIS in 2012. Moscow: M. Publishing Group of Russian Cancer Research Center; 2014b. p. 226.

    Google Scholar 

  • Godley P, Stinchcombe T. Renal cell carcinoma. Curr Opin Oncol. 1999;11(3):213–7.

    Article  CAS  PubMed  Google Scholar 

  • Gohji K, Hara I, Gotoh A, et al. Multifocal renal cell carcinoma in Japanese patients with tumors with maximal diameters of 50 mm or less. J Urol. 1998;159(4):1144–7.

    Article  CAS  PubMed  Google Scholar 

  • Harada Y, Nonomura N, Kondo M, et al. Clinical study of brain metastasis of renal cell carcinoma. Eur Urol. 1999;36:230–5.

    Article  CAS  PubMed  Google Scholar 

  • Jemal A, Siegel R, Ward E, et al. Cancer statistics. CA Cancer J Clin. 2007;57(1):43–66.

    Article  PubMed  Google Scholar 

  • Karami S, Schwartz K, Purdue M, et al. Family history of cancer and renal cell cancer risk in Caucasians and African Americans. Br J Cancer. 2010;102(11):1676–80.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kirkali Z, Tuz E, Mungan M. Recent advances in kidney cancer and metastatic disease. BJU Int. 2001;88:818–24.

    Article  CAS  PubMed  Google Scholar 

  • Kleinberg L. Brain metastases: a multidisciplinary approach. New York: Demos; 2009. p. 224.

    Google Scholar 

  • Kusuda Y, Miyake H, Terakawa T, et al. Treatment of brain metastases from renal cell carcinoma with sunitinib and radiotherapy: our experience and review of the literature. Int J Urol. 2011;18:326–9.

    Article  PubMed  Google Scholar 

  • Lang H, Lindner V, Martin M, et al. Prognostic value of multifocality on progression and survival in localized renal cell carcinoma. Eur Urol. 2004;45(6):749–53.

    Article  PubMed  Google Scholar 

  • Lindblad P, Mellemgaard A, Schlehofer B, et al. International renal-cell cancer study. V. Reproductive factors, gynecologic operations and exogenous hormones. Int J Cancer. 1995;61:192–8.

    Article  CAS  PubMed  Google Scholar 

  • Liu H, Wang X, Zhou G, et al. Cancerous inhibitor of protein phosphatase 2A is overexpressed in cervical cancer and upregulated by human papillomavirus 16 E7 oncoprotein. Gynecol Oncol. 2011;122:430–6.

    Article  CAS  PubMed  Google Scholar 

  • Ljungberg B, Campbell S, Choi H, et al. The epidemiology of renal cell carcinoma. Eur Urol. 2011;60:615–21.

    Article  PubMed  Google Scholar 

  • Loudyi A, Samlowski W. Brain metastasis in renal cell carcinoma patients. Chapter 6. In: Hayat MA, editor. Tumors of the central nervous system, vol. 3. Dordrecht: Springer; 2011.

    Google Scholar 

  • Marshall M, Butler K, Pearson T, et al. Low incidence of asymptomatic brain metastases in patients with renal cell carcinoma. Urology. 1990;36:300–2.

    Article  CAS  PubMed  Google Scholar 

  • Mori Y, Kondziolka D, Flickinger J, et al. Stereotactic radiosurgery for cerebral metastatic melanoma: factors affecting local disease control and survival. Int J Radiat Oncol Biol Phys. 1998;42:581–9.

    Article  CAS  PubMed  Google Scholar 

  • Motzer R, Bacik J, Schwartz L, et al. Prognostic factors for survival in previously treated patients with metastatic renal cell carcinoma. J Clin Oncol. 2004;22(3):454–63.

    Article  PubMed  Google Scholar 

  • Muscat J. The epidemiology of renal cell carcinoma. In: Bukowski RM, Novick AC, editors. Renal cell carcinoma: molecular biology, immunology, and clinical Management. Totowa: Human Press; 2000. p. 3–13.

    Chapter  Google Scholar 

  • Nieder C, Spanne O, Mehta M, et al. Presentation, patterns of care, and survival in patients with brain metastases: what has changed in the last 20 years? Cancer. 2011a;117(11):2505–12.

    Article  PubMed  Google Scholar 

  • Nieder C, Spanne O, Nordoy T, et al. Treatment of brain metastases from renal cell cancer. Urol Oncol. 2011b;29(4):405–10.

    Article  PubMed  Google Scholar 

  • Nussbaum E, Djalilian H, Cho K, et al. Brain metastases. Histology, multiplicity, surgery, and survival. Cancer. 1996;78(8):1781–8.

    Article  CAS  PubMed  Google Scholar 

  • Parashar B, Patro K, Smith M, et al. Role of radiation therapy for renal tumors. Semin Intervent Radiol. 2014;31(1):86–90.

    Article  PubMed  PubMed Central  Google Scholar 

  • Patchell R, Tibbs P, Walsh J, et al. A randomized trial of surgery in the treatment of single metastases to the brain. N Engl J Med. 1990a;322:753–9.

    Article  Google Scholar 

  • Patchell R, Tibbs P, Walsh J, et al. A randomized trial of surgery in the treatment of single metastases to the brain. New Engl J Med. 1990b;322(8):494–500.

    Article  CAS  PubMed  Google Scholar 

  • Pfaffenroth E, Linchan W. Genetic basis for kidney cancer: opportunity for disease-specific approaches to therapy. Expert Opin Biol Ther. 2008;8(6):779–90.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Radley M, McDonald J, et al. Late solitary cerebral metastases from renal cell carcinoma: report of two cases. Surg J Neurol. 1993;39:230–4.

    Article  CAS  Google Scholar 

  • Raman R, Vaena D. Immunotherapy in metastatic renal cell carcinoma: a comprehensive review. Biomed Res Int. 2015;2015:8.

    Article  Google Scholar 

  • Richstone L, Scherr D, Reuter V, et al. Multifocal renal cortical tumors: frequency, associated clinicopathological features and impact on survival. J Urol. 2004;171(2, part 1):615–20.

    Article  PubMed  Google Scholar 

  • Roser F, Rosahl S, Samii M. Single cerebral metastasis 3 and 19 years after primary renal cell carcinoma: case report and review of the literature. J Neurol Neurosurg Psychiatry. 2002;72(2):257–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Saitoh H. Distant metastasis of renal adenocarcinoma. Cancer. 1981;48:1487–91.

    Article  CAS  PubMed  Google Scholar 

  • Shus AV. Optimization of diagnostic and treatment tactics in multifocal renal cancer. Intern Med J. 2003;9(3):95–7.

    Google Scholar 

  • Steliarova-Foucher E, Parkin D. Cancer registration in Europe. In: Razum O, Spallek J, Reeske A, Arnold M, editors. Migration-sensitive cancer registration in Europe. Challenges and potentials. Frankfurt: Peter Lang Verlag; 2011.

    Google Scholar 

  • Wronski M, Arbit E, Bilsky M, et al. Resection of brain metastases (BMET) from breast cancer (BRC): retrospective review of 70 patients (Meeting abstract). Proc An Meet ASCO 1996;15:A165.

    Google Scholar 

  • Yurin AG. Epidemiology, new in classification of kidney cancer. Arch Pathol. 2007;69(1):49–54.

    Google Scholar 

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Authors and Affiliations

  1. N.N. Blockhin Russian Cancer Research Center, Moscow, Russia

    Mikhail Dolgushin

  2. N.N. Burdenko National Scientific and Practical Center for Neurosurgery, Moscow, Russia

    Valery Kornienko & Igor Pronin

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  1. Mikhail Dolgushin
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  2. Valery Kornienko
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Dolgushin, M., Kornienko, V., Pronin, I. (2018). Renal Cell Carcinoma (RCC). In: Brain Metastases. Springer, Cham. https://doi.org/10.1007/978-3-319-57760-9_15

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  • DOI: https://doi.org/10.1007/978-3-319-57760-9_15

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