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This chapter discusses the extensive use of a variety of quackery remedies in the nineteenth century, promoted by charlatans with the most extravagant promises. Their popularity and wide use posed, in addition to the problem of the assessment of the efficacy , the problem of the safety of these preparations. Indeed, these remedies sometimes contained toxic ingredients, and in some instances caused severe poisoning and death. To avoid these catastrophes, specific legislative measures were adopted after the First World War and regulatory agencies were established in the USA and later in other countries; after the Second World War , evidence of efficacy was also required for medicinal products. Evidence-based medicine thus provided safe and effective medicines, but did this happen to antidepressants ?
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