Written in the Genes

  • Tullio GiraldiEmail author


This chapter discusses molecular biology, with its recent outstanding progresses, and how it has been applied to identify the role of genetic-molecular factors in health and disease . Individual variations, caused by a genetic polymorphism, have been identified in the gene coding for the serotonin transporter , which was soon found to be implied in many conditions such as neuroticism , anxiety , even wellbeing and happiness , and rapidly became the most studied polymorphism in psychiatry . It was found to be associated with depression, particularly together with stressful life events, and with response to selective serotonin reuptake inhibitor antidepressants . The Genome-Wide Association Scan was later also performed on wide portions of the genome in large populations. The results obtained so far are disappointing, and only minuscule fractions of the phenomena studied can be explained, with negligible clinical relevance.


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© The Author(s) 2017

Authors and Affiliations

  1. 1.University of TriesteTriesteItaly

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