Abstract
This chapter details the general principles of labeling of ligands with radionuclides. Different physiological mechanisms that are taken advantage of in radiolabeling and different physicochemical factors affecting radiolabeling are discussed in detail. While general methods of radiolabeling have been elucidated, iodination and 99mTc are elaborately described. Various methods of radioiodination of different ligands for nuclear medicine imaging are detailed. Since 99mTc is a very important radionuclide for nuclear medicine studies, its properties and various chemical reactions involved in 99mTc labeling of many ligands are described in detail. Various oxidation states of 99mTc in labeled compounds are discussed. The basic principles of manufacturing kits for different radiopharmaceuticals are briefly described. A brief section is devoted to preparation of colloidal substances, and also different additives and preservatives that are often added to radiopharmaceuticals to maintain their integrity are discussed.
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Saha, G.B. (2018). Radiopharmaceuticals and General Methods of Radiolabeling. In: Fundamentals of Nuclear Pharmacy. Springer, Cham. https://doi.org/10.1007/978-3-319-57580-3_6
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DOI: https://doi.org/10.1007/978-3-319-57580-3_6
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