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Hysteroscopy pp 683–687Cite as

Endometrial Osseous Metaplasia

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Abstract

Bone metaplasia of the endometrium is an uncommon entity characterized by the presence of fragments of mature bone in the endometrium. Without presenting a defined syndrome, it is often associated with infertility, bleeding, and pain. The origin of this bone tissue has been interpreted as sequelae of early abortion, with no basis other than the statistical association between the two conditions. However, recent studies based on genetic identification techniques of DNA allow reinterpreting the phenomenon and establish that endometrial bone metaplasia originates from the patient’s stem cells lying in the endometrium. Diagnosis is based on ultrasound detection and subsequent confirmation by hysteroscopy, which usually shows excellent clinical results with more than 70% of cases of regaining fertility.

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References

  1. Virchow R. Ueber metaplasia. Virchows Arch Abt Pathol Anat. 1884;97:410.

    Article  Google Scholar 

  2. Khan SN, Modi M, Hoyos LR, Imudia AN, Awonuga AO. Bone in the endometrium: a review. Int J Fertil Steril. 2016;10:154–61.

    CAS  PubMed  PubMed Central  Google Scholar 

  3. Parente RC, Patriarca MT, de Moura Neto RS, de Olivaira MA, Lasmar RB, de Holanda Mendes P, et al. Genetic analysis of the cause of endometrial osseous metaplasia. Obstet Gynecol. 2009;114(5):1103–8.

    Article  CAS  PubMed  Google Scholar 

  4. Meng X, Ichim TE, Zhong J, Rogers A, Yin Z, Jackson J, Wang H, Ge W, Bogin V, Chan KW, Thébaud B, Riordan NH. Endometrial regenerative cells: a novel stem cells population. J Transl Med. 2007;5:57.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Cayuela E, Perez-Medina T, Vilanova J, Alejo M, Cañadas P. True osseous metaplasia of the endometrium: the bone is not from a fetus. Fertil Steril. 2009;91:1293.e1–4.

    Article  Google Scholar 

  6. Lousquy R, Deffieux X, Gervaise A, Faivre E, Frydman R, Fernandez H. Fertility after hysteroscopic management of osseous metaplasia of the endometrium. Int J Gynecol Obstet. 2009; doi:10.1016/j.ijgo.2009.03.051.

  7. Cicinelli E, Stanziano A, Parisi C, Mariaccio M, Causio F. Hysteroscopic diagnosis and treatmen of endocervical ossification: a case report. J Minim Invasive Gynecol. 2005;12:159–61.

    Article  PubMed  Google Scholar 

  8. Cayuela E, Salas M, Fontanet C, Pérez-Medina T. Organización de una unidad de histeroscopia. In: Garza Leal, Bustos-López, editor. Cirugía Endoscópica en Ginecología. Mexico City: Panamericana; 2011. p. 237–50.

    Google Scholar 

  9. Pérez-Medina T, Sancho-Saúco J, Rios M, Pereira A, Argila N, Cabezas E, Cayuela E. Hysteroscopy in pregnancy-related conditions: descriptive analysis in 273 patiens. J Minim Invasive Gynecol. 2014;21:417–25.

    Article  PubMed  Google Scholar 

  10. Alves LF, Pessanha LB, Oliveira GA, et al. Endometrial osseous metaplasia: sonographic, radiological and histopathological findings. Radiol Bras. 2016;49:56–64.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Hospital General Universitari de l’Hospitalet, Consorci Sanitari Integral, Av Josep Molins 29-41, 08906 L’Hospitalet de Llobregat, Barcelona, Spain

    Enric Cayuela, María del Río, Federico Heredia, Laura Acín, Patricia Zarco, Natalia Giraldo & Estefania Llanos

  2. Department of Anatomy, University of Barcelona, Barcelona, Spain

    Josep Vilanova

Authors
  1. Enric Cayuela
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  2. Josep Vilanova
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  3. María del Río
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  4. Federico Heredia
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  5. Laura Acín
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  6. Patricia Zarco
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  7. Natalia Giraldo
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  8. Estefania Llanos
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Corresponding author

Correspondence to Enric Cayuela .

Editor information

Editors and Affiliations

  1. Department of Obstetrics and Gynaecology, Ospedale Vito Fazzi, Lecce, Italy

    Andrea Tinelli

  2. Hysteroscopy Unit, Gutenberg Institute, Malaga, Spain

    Luis Alonso Pacheco

  3. Hysteroscopy Unit, Hospital Del Mar, Barcelona, Spain

    Sergio Haimovich

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© 2018 Springer International Publishing AG

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Cayuela, E. et al. (2018). Endometrial Osseous Metaplasia. In: Tinelli, A., Alonso Pacheco, L., Haimovich, S. (eds) Hysteroscopy. Springer, Cham. https://doi.org/10.1007/978-3-319-57559-9_60

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  • DOI: https://doi.org/10.1007/978-3-319-57559-9_60

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-57558-2

  • Online ISBN: 978-3-319-57559-9

  • eBook Packages: MedicineMedicine (R0)

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