Hysteroscopy pp 291-299 | Cite as

Tamoxifen: An Update

  • Jesus S. Jimenez
  • Alvaro Diez
  • Alejandro Olloqui


Tamoxifen is a selective estrogen receptor modulator (SERM). These agents act as competitive inhibitors of estrogens, binding to estrogen receptors (ERs) and, depending on the tissue of action, having an agonist or antagonist effect on these receptors. The mechanism of action and main effects of tamoxifen on endometrium will be reviewed in this chapter. Tamoxifen has shown to slightly increase the risk of atypical endometrial lesions, which can be diagnosed with hysteroscopy. An optimal baseline evaluation and follow-up of patients treated with tamoxifen, in order to diagnose and treat these lesions has not been established.


Tamoxifen Endometrial changes Hysteroscopy findings 


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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Jesus S. Jimenez
    • 1
  • Alvaro Diez
    • 1
  • Alejandro Olloqui
    • 1
  1. 1.Diagnostic—Surgical Hysteroscopy Unit, Obstetrics and Gynecology Service, Hospital 12 October, School of MedicineComplutense UniversityMadridSpain

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